HOME >> BIOLOGY >> NEWS
Setting the standard for computer models of life

Biologists are making a concerted effort to catalogue all the molecular components of living things, from the smallest molecules and ions to the genetic code. These 'parts lists' help them to build computer models that simulate living processes. By combining models of simple processes they hope to understand and faithfully represent how entire biological systems - be they cells, organs, organisms or ecological niches - work. As well as contributing to the understanding of biology, this approach has numerous applications: for example, diseases can be simulated, and treatment regimens optimised.

"The computational systems biology community has made enormous progress in improving access to models," explains the EMBL-EBI's Nicolas Le Novre, lead author of the paper. "We've begun to share programming languages for encoding them (e.g. systems biology markup language, www.sbml.org) and to build public repositories so we can share them (e.g. www.ebi.ac.uk/biomodels). The current challenge is quality control: systems biologists won't use publicly available models if they can't search them properly, of if a model's reuse is hampered by a tiny mistake in the way that it's encoded. MIRIAM is an attempt to address these issues."

MIRIAM has two parts: (1) a set of checks that match a model to its description ('reference correspondence', often a publication in a scientific journal), and (2) a set of 'annotation schemes'. The first of these documents the model's provenance: who created it, whether it's been modified, and a stable link to its full description; the second scheme links the components of the model to relevant bioinformatics resources: for example, a model of alcohol metabolism in the liver would be annotated with links to the protein databases for all the enzymes involved in this pathway, and database links to all the relevant metabolites. The aim of these annotation schemes
'"/>

Contact: Cath Brooksbank
cath@ebi.ac.uk
44-012-234-92525
European Molecular Biology Laboratory
6-Dec-2005


Page: 1 2

Related biology news :

1. Setting sights on the drugs of the future
2. Setting the stage to find drugs against SARS
3. UC experts detail new standard for cleaner transportation fuels
4. DOE JGI sets gold standard for metagenomic data analysis
5. Enhancing chemotherapys efficacy: New agent has synergistic effect with standard drugs
6. UN, industry, others partner to create world standards for e-scrap recycling, harvesting components
7. AAAS applauds nationwide science and math standards based on existing guidelines
8. Study of toxins in Houston air warrants new standards
9. Addition of topotecan to standard treatment is not recommended for ovarian cancer patients
10. Neurologists developing first standardized measurement scale for dyskinesia in Parkinsons patients
11. Nilotinib appears to help chronic myelogenous leukemia patients when standard care fails

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Setting the standard for computer models life

(Date:4/23/2014)... contribute to early fetal death according to a new ... Children,s Hospital Los Angeles and Ulaanbaatar, Mongolia the ... paper published today in the journal BMC Pregnancy ... between seasonal ambient air pollutants and pregnancy loss in ... the highest levels of air pollution of all world ...
(Date:4/23/2014)... Like a hungry diner ripping open a dinner roll, ... must tear open a hydrogen molecule. Now researchers have ... the two halves of its hydrogen feast. The view ... make the catalyst work better for alternative energy uses. ... shown precisely where the hydrogen halves end up in ...
(Date:4/23/2014)... research shows that male black widow spiders prefer their ... example of mate preference by male spiders. ... and Maydianne Andrade, a professor in UTSC,s Department of ... the wild that males overwhelmingly chose to mate with ... can tell whether a potential mate is well-fed and ...
Breaking Biology News(10 mins):Pollutants from coal-burning stoves strongly associated with miscarriages in Mongolia 2Halving hydrogen 2Halving hydrogen 3Halving hydrogen 4Picky male black widow spiders prefer well-fed virgins 2
(Date:1/14/2014)... 14, 2014 EquitiesIQ, a leading informational ... ALQA). Alliqua is an emerging biomedical company acquiring, developing, ... care market. , Free report download: http://equitiesiq.com/reports/alliqua/ ... seasoned management team and Board, which launched the company’s ...
(Date:1/14/2014)... BETHESDA, Md. , Jan. 14, 2014  Organovo ... institutes from the National Institutes of Health (NIH) to ... more effective treatments to patients on a faster timeline. ... Translational Sciences (NCATS) and the National Eye Institute (NEI) ...
(Date:1/14/2014)... 2014 In recent years, growing suspicion ... in product development and promotion has led to unprecedented ... fueled by concerns about the insidious impact of commercialization ... spectacular fines to the world’s biggest pharmas for illegal ...
(Date:1/14/2014)... Rockville, MD (PRWEB) January 14, 2014 ... dedicated to developing innovative information technology solutions for ... other health care stakeholders, announced today the signing ... the US Food and Drug Administration (FDA). ...
Breaking Biology Technology:EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3Organovo Announces Collaboration with National Institutes of Health 2Organovo Announces Collaboration with National Institutes of Health 3The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 3Global Record Systems Announces Research Collaboration Agreement with FDA to Create a Novel “Big Data” Paradigm for Collection of Patient Safety and Outcomes Information 2
Cached News: