HOME >> BIOLOGY >> NEWS
Setting the standard for computer models of life

Biologists are making a concerted effort to catalogue all the molecular components of living things, from the smallest molecules and ions to the genetic code. These 'parts lists' help them to build computer models that simulate living processes. By combining models of simple processes they hope to understand and faithfully represent how entire biological systems - be they cells, organs, organisms or ecological niches - work. As well as contributing to the understanding of biology, this approach has numerous applications: for example, diseases can be simulated, and treatment regimens optimised.

"The computational systems biology community has made enormous progress in improving access to models," explains the EMBL-EBI's Nicolas Le Novre, lead author of the paper. "We've begun to share programming languages for encoding them (e.g. systems biology markup language, www.sbml.org) and to build public repositories so we can share them (e.g. www.ebi.ac.uk/biomodels). The current challenge is quality control: systems biologists won't use publicly available models if they can't search them properly, of if a model's reuse is hampered by a tiny mistake in the way that it's encoded. MIRIAM is an attempt to address these issues."

MIRIAM has two parts: (1) a set of checks that match a model to its description ('reference correspondence', often a publication in a scientific journal), and (2) a set of 'annotation schemes'. The first of these documents the model's provenance: who created it, whether it's been modified, and a stable link to its full description; the second scheme links the components of the model to relevant bioinformatics resources: for example, a model of alcohol metabolism in the liver would be annotated with links to the protein databases for all the enzymes involved in this pathway, and database links to all the relevant metabolites. The aim of these annotation schemes
'"/>

Contact: Cath Brooksbank
cath@ebi.ac.uk
44-012-234-92525
European Molecular Biology Laboratory
6-Dec-2005


Page: 1 2

Related biology news :

1. Setting sights on the drugs of the future
2. Setting the stage to find drugs against SARS
3. UC experts detail new standard for cleaner transportation fuels
4. DOE JGI sets gold standard for metagenomic data analysis
5. Enhancing chemotherapys efficacy: New agent has synergistic effect with standard drugs
6. UN, industry, others partner to create world standards for e-scrap recycling, harvesting components
7. AAAS applauds nationwide science and math standards based on existing guidelines
8. Study of toxins in Houston air warrants new standards
9. Addition of topotecan to standard treatment is not recommended for ovarian cancer patients
10. Neurologists developing first standardized measurement scale for dyskinesia in Parkinsons patients
11. Nilotinib appears to help chronic myelogenous leukemia patients when standard care fails

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Setting the standard for computer models life

(Date:7/23/2014)... Chrysomya megacephala is commonly found in dead bodies ... time of death, referred to as the post mortem ... C. megacephala from Tamil Nadu is provided for ... characterization through generation of DNA barcoding. This study, significant ... Biodiversity Data Journal . , Chrysomya megacephala ...
(Date:7/23/2014)... New Rochelle, NY -- The potential for clinical ... for transplant-based therapeutic strategies has previously been hindered ... the development of tumors. The ability to use ... for the treatment of heart disease, specifically acute ... Stem Cells and Development , a peer-reviewed ...
(Date:7/23/2014)... MINNETONKA, Minn. , July 23, 2014 /PRNewswire/ ... technology company specializing in clinical study management systems, ... West , a proven life sciences industry executive ... named Chief Operating Officer (COO).  Clareece will be ... and sales growth, operational efficiency and quality product/service ...
Breaking Biology News(10 mins):Dead body feeding larvae useful in forensic investigations 2MedNet Appoints Clareece West As Chief Operating Officer 2
(Date:7/23/2014)... July 23, 2014 ... of Trendlines Agtech , announced it has ... Israel,s leading agricultural thermoplastics applications companies. ... Valentis,s technology combines nanocrystalline cellulose (NCC), a biodegradable, ... additional nanoparticles to produce highly improved polymeric films. ...
(Date:7/23/2014)... regulated information -- UCB today announced an important advance ... topline results from the latest Phase 3 study ... evaluate the efficacy and safety of brivaracetam ... to placebo, as adjunctive treatment in adult focal ... despite treatment with one or two concomitant antiepileptic ...
(Date:7/23/2014)... 2014  Sofinnova Ventures, a Menlo Park ... of Sofinnova Venture Partners IX, L.P. at the hard ... initial fund target of $425 million. Sofinnova ... Consistent with recent funds, SVP IX will provide capital ... along with select investments in earlier stage opportunities. Investments ...
(Date:7/23/2014)... 2014 OncLive® is pleased to ... joined its Strategic Alliance Partnership program. , ... UNC Lineberger will have the opportunity to work ... its cutting-edge research initiatives, community-directed cancer prevention programs, ... work with OncLive to educate their peers by ...
Breaking Biology Technology:Valentis Nanotech Signs MOU to Integrate Technology in Thermoplastics Production 2Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 2Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 3Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 4Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 5Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 6Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 7Sofinnova Raises $500 Million Biotech Venture Fund 2OncLive Expands Its Strategic Alliance Partnership Program With the Addition of UNC Lineberger Comprehensive Cancer Center 2OncLive Expands Its Strategic Alliance Partnership Program With the Addition of UNC Lineberger Comprehensive Cancer Center 3
Cached News: