HOME >> BIOLOGY >> NEWS
Setting the standard for computer models of life

Biologists are making a concerted effort to catalogue all the molecular components of living things, from the smallest molecules and ions to the genetic code. These 'parts lists' help them to build computer models that simulate living processes. By combining models of simple processes they hope to understand and faithfully represent how entire biological systems - be they cells, organs, organisms or ecological niches - work. As well as contributing to the understanding of biology, this approach has numerous applications: for example, diseases can be simulated, and treatment regimens optimised.

"The computational systems biology community has made enormous progress in improving access to models," explains the EMBL-EBI's Nicolas Le Novre, lead author of the paper. "We've begun to share programming languages for encoding them (e.g. systems biology markup language, www.sbml.org) and to build public repositories so we can share them (e.g. www.ebi.ac.uk/biomodels). The current challenge is quality control: systems biologists won't use publicly available models if they can't search them properly, of if a model's reuse is hampered by a tiny mistake in the way that it's encoded. MIRIAM is an attempt to address these issues."

MIRIAM has two parts: (1) a set of checks that match a model to its description ('reference correspondence', often a publication in a scientific journal), and (2) a set of 'annotation schemes'. The first of these documents the model's provenance: who created it, whether it's been modified, and a stable link to its full description; the second scheme links the components of the model to relevant bioinformatics resources: for example, a model of alcohol metabolism in the liver would be annotated with links to the protein databases for all the enzymes involved in this pathway, and database links to all the relevant metabolites. The aim of these annotation schemes
'"/>

Contact: Cath Brooksbank
cath@ebi.ac.uk
44-012-234-92525
European Molecular Biology Laboratory
6-Dec-2005


Page: 1 2

Related biology news :

1. Setting sights on the drugs of the future
2. Setting the stage to find drugs against SARS
3. UC experts detail new standard for cleaner transportation fuels
4. DOE JGI sets gold standard for metagenomic data analysis
5. Enhancing chemotherapys efficacy: New agent has synergistic effect with standard drugs
6. UN, industry, others partner to create world standards for e-scrap recycling, harvesting components
7. AAAS applauds nationwide science and math standards based on existing guidelines
8. Study of toxins in Houston air warrants new standards
9. Addition of topotecan to standard treatment is not recommended for ovarian cancer patients
10. Neurologists developing first standardized measurement scale for dyskinesia in Parkinsons patients
11. Nilotinib appears to help chronic myelogenous leukemia patients when standard care fails

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/9/2016)... innovation leader in attendance control systems is proud to announce the introduction of fingerprint ... sure the right employees are actually signing in, and to even control the opening ... ... ... Photo ...
(Date:6/3/2016)... June 3, 2016 ... Nepal hat ein ... hochsicherer geprägter Kennzeichen, einschließlich Personalisierung, Registrierung und ... der Produktion und Implementierung von Identitätsmanagementlösungen. Zahlreiche ... im Januar teilgenommen, aber Decatur wurde als ...
(Date:6/2/2016)... 2016 Perimeter Surveillance & Detection ... Physical Infrastructure, Support & Other Service  The ... offers comprehensive analysis of the global Border Security ... revenues of $17.98 billion in 2016. Now: ... leader in software and hardware technologies for advanced video ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... 2016 , ... Supplyframe, the Industry Network for electronics hardware ... . Located in Pasadena, Calif., the Design Lab’s mission is to bring together ... built and brought to market. , The Design Lab is Supplyframe’s physical representation ...
(Date:6/23/2016)... ... June 23, 2016 , ... In a new case report published ... how a patient who developed lymphedema after being treated for breast cancer benefitted from ... the paradigm for dealing with this debilitating, frequent side effect of cancer treatment. ...
(Date:6/23/2016)... Calif. , June 23, 2016  Blueprint Bio, ... biological discoveries to the medical community, has closed its ... Matthew Nunez . "We have received ... with the capital we need to meet our current ... essentially provide us the runway to complete validation on ...
(Date:6/23/2016)... , June 23, 2016 On ... session at 4,833.32, down 0.22%; the Dow Jones Industrial Average ... 500 closed at 2,085.45, down 0.17%. Stock-Callers.com has initiated coverage ... INFI ), Nektar Therapeutics (NASDAQ: NKTR ), Aralez ... Inc. (NASDAQ: BIND ). Learn more about these ...
Breaking Biology Technology:
Cached News: