HOME >> BIOLOGY >> NEWS
Short chromosomes put cancer cells in forced rest

A Johns Hopkins team has stopped in its tracks a form of blood cancer in mice by engineering and inactivating an enzyme, telomerase, thereby shortening the ends of chromosomes, called telomeres.

"Normally, when telomeres get critically short, the cell commits suicide as a means of protecting the body," says Carol Greider, Ph.D., the Daniel Nathans chair of molecular biology and genetics at Johns Hopkins. Her study, appearing online this month at Cancer Cell, uncovers an alternate response where cells simply - and permanently - stop growing, a process known as senescence.

In an unusual set of experiments, the research team first mated mice with nonoperating telomerase to mice carrying a mutation that predisposed them to Burkitts lymphoma, a rare but aggressive cancer of white blood cells. Telomerase helps maintain the caps or ends of chromosomes called telomeres, which shrink each time a cell divides and eventually - when the chromosomes get too short - force the cell to essentially commit suicide. Such cell death is natural, and when it fails to happen, the result may be unbridled cell growth, or cancer.

The first generation pups born to these mice contained no telomerase and very long telomeres. These mice all developed lymphomas by the time they were 7 months old. The researchers then continued breeding the mice to see what would happen in later generations. By the fifth generation, the researchers discovered that the mice had short telomeres and stopped developing lymphomas.

When the researchers blocked the suicide machinery in these fifth-generation mice, they were very surprised to find that the mice still remained cancer free.

"We were confused as to what was going on; we thought for sure that blocking the cells ability to commit suicide would lead to the cancers returning," says Greider. A closer look showed microtumors in the mices lymph nodes that had begun the road to cancer, but stopped, falling inst
'"/>

Contact: Nick Zagorski
nzagors1@jhmi.edu
443-287-2251
Johns Hopkins Medical Institutions
25-Apr-2007


Page: 1 2

Related biology news :

1. Short-circuit found in ocean circulation
2. Short-term studies suggest that whole grain oats may reduce risk factors for coronary heart disease
3. Shortening chromosomes cause for earlier cancer onset in families with rare syndrome
4. Shorter tuberculosis therapies could lead to substantial reductions in cases and deaths
5. When it counts: Shortening imaging time for individuals with suspected heart problems
6. Short-term yoga training expands breathing and lung capacity in young, healthy adults
7. Georgia Tech study: Short glass shapes cause over-pouring of alcohol
8. Shorter colds, milder flu may follow from newly revealed immune mechanism
9. Short-term social stress may benefit immune response to infection
10. Biologists at Tufts University discover 1 reason why chromosomes break, often leading to cancer
11. Researchers shed light on shrinking of chromosomes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/11/2017)... 2017  Michael Johnson, co-founder of Visikol Inc. a company originally ... been named to the elite "Forbes 30 Under 30" list in ... people in 20 fields nationwide to be recognized as a leader ... were selected. ... is currently a PhD candidate at Rutgers University. ...
(Date:1/6/2017)... , Jan. 5, 2017  SomaLogic announced today ... Life Alliance" established by iCarbonX, the ... build a "Global Digital Health Ecosystem that can ... combination of individual,s biological, behavioral and psychological data, ... between the companies, SomaLogic will provide proteomics data ...
(Date:1/4/2017)... the thousands of attendees at this year,s International Consumer Electronics Show (CES), ... measurement devices and services, will be featuring its new line of ULTRA ... special CES Exhibit Suite , the new upper arm and wrist ... WellnessConnected product platform.  Continue Reading ... ...
Breaking Biology News(10 mins):
(Date:1/16/2017)...  Eurofins Genomics today announced the expansion of its ... receive their primers in a shorter turnaround time, without ... with other providers. Express oligos are available for anyone ... no additional fee. Researchers use the oligos ... sequencing, genotyping, site-directed mutagenesis, and cloning. Often, they are ...
(Date:1/13/2017)... 2017 Research and Markets has announced the ... Global Forecast to 2021" report to their offering. ... The biosimilars market is ... Billion in 2016, at a CAGR of 26.3%. ... manufacturing type, and application. Factors such as rising incidence of various ...
(Date:1/13/2017)... NY (PRWEB) , ... January 13, 2017 , ... ... meet every cuvette-related demand that it has found among its diverse customer base. ... for use in most brands electroporators including BTX and Bio-Rad. FireflySci is ...
(Date:1/12/2017)... ... January 12, 2017 , ... Each year, Crain’s Detroit Business News ranks the ... evaluates the patent estate of a company, its impact and significance, and the likelihood ... the way in technologies that transform energy sources such as low dose X-ray and ...
Breaking Biology Technology:
Cached News: