HOME >> BIOLOGY >> NEWS
Signal for inflammation linked to Ras-induced tumor growth

Cancer progression is dependent on the ability of tumor cells to interact with and favorably influence their environment. For instance, if a tumor is going expand, it is absolutely critical that new blood vessels are formed so that an adequate blood supply is in place to feed the growing tissue. A new research study published in the November issue of Cancer Cell demonstrates that a cytokine, a chemical signal that stimulates inflammation, plays a critical role in the initiation of new vasculature formation required to promote tumor progression.

Previous research has suggested that there may be a link between cancer-associated angiogenesis and inflammation. The protooncogene Ras has also been implicated in tumor-driven blood vessel generation. Ras is abnormally activated in nearly one quarter of all human cancers and is involved in many aspects of tumor progression, including interactions between tumor cells and the surrounding environment. However, the mechanisms that underlie these interactions are unclear.

Dr. Dafna Bar-Sagi from the Department of Molecular Genetics and Microbiology at the State University of New York at Stony Brook examined whether Ras-mediated induction of the inflammatory mediator CXCL-8 was required for tumor growth and angiogenesis in a mouse model. The researchers found that CXCL-8 production was required for Ras-stimulated tumor inflammation, vascularization, and growth. In addition, inhibition of CXCL-8 function in tumors expressing Ras led to a marked decrease in tumor angiogenesis.

Molecules that modulate CXCL-8 expression are known targets of the Ras signaling pathway, establishing a physiological link between these signaling molecules. The researchers conclude that in response to Ras activation, proinflammatory cytokines such as CXCL-8 may recruit immune cells and endothelial cells to tumor sites, representing a new mechanism for cancer-driven blood vessel generation. According to Dr. Bar-Sagi, "Our findin
'"/>

Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
15-Nov-2004


Page: 1 2

Related biology news :

1. Signaling for cartilage
2. Funnel in the eye: Signal focusing increases photosensitivity
3. Signaling proteins may represent biomarkers for melanoma
4. Signaling protein builds bigger, better bones in mice
5. Penn researchers discover how key protein stops inflammation
6. Gene variations directly link inflammation to an increased risk for lung cancer
7. p53 gene mutations and inflammation trigger skin cancer
8. Remicade data in ankylosing spondylitis show improvement in spinal mobility and spinal inflammation
9. Hot on the TRAIL of controlling inflammation in bacterial meningitis
10. NIAID supports research into etiology of fungal-induced inflammation in chronic sinusitis
11. Omega-3 fatty acids affect risk of depression, inflammation

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Signal for inflammation linked Ras induced tumor growth

(Date:3/31/2015)... YORK , March 31, 2015  Elephant Talk ... "Company"), a global provider of Software Defined Network Architecture ... today announced total revenue of approximately $20.4 million for ... a restated $19.5 million for the year ended December ... calendar 2014, the Company had completed its multi-year transition ...
(Date:3/31/2015)... NEW YORK , March 31, 2015   ... announced the launch of the Post-Surgical Pain Management TRACKER, ... data products tracking usage trends in the medical device ... monthly access to data including treatment volumes, market share, ... manage the pain associated with joint surgery. ...
(Date:3/30/2015)... Mar. 26, 2015 Research and Markets ... "Global Gesture Recognition Market in Automotive Sector 2014-2018" ... forecast the Global Gesture Recognition market in Automotive Sector ... period 2013-2018. Gesture recognition is the ability ... gestures of an individual. Gesture recognition technology can be ...
Breaking Biology News(10 mins):Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 2Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 3Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 4Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 5Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 6Guidepoint Launches Post-Surgical Pain Management TRACKER 2Guidepoint Launches Post-Surgical Pain Management TRACKER 3Global Gesture Recognition Market in Automotive Sector Report 2015 - Growing Number of Partnerships 2
(Date:3/31/2015)... -- Materials in Society Lecture Series at ... 2015   Elsevier , a world-leading provider ... publishing home of Materials Today , announced that its ... Materials in Society  Lecture Series . The inaugural ... International Conference on Materials for Advanced Technologies (ICMAT) to ...
(Date:3/31/2015)... (PRWEB) March 31, 2015 Pittcon 2015, ... Applied Spectroscopy, ended on March 12, in New Orleans ... $21 million as estimated by the New Orleans Convention ... than 14,200 conferees and exhibitor personnel. Those who ... the conferee number. For the third year, the co-location ...
(Date:3/31/2015)... 2015  Sonoa Health, a health tech startup based ... a world-first consumer health portal, Health&, which brings together ... and more. Today, the Company appointed respected ... who brings to the table more than 18-years experience ... working closely with the biggest names in Silicon Valley ...
(Date:3/31/2015)... WHIPPANY, N.J. , March 31, 2015 /PRNewswire/ ... the Broad Institute of Massachusetts Institute of Technology ... and drug discovery. The goal of this new ... from human genetics to help create new cardiovascular ... our collaboration with the Broad Institute to the ...
Breaking Biology Technology:Elsevier Materials Science Council Introduces the Materials in Society Lecture Series at the International Conference on Materials for Advanced Technologies (ICMAT) 2Elsevier Materials Science Council Introduces the Materials in Society Lecture Series at the International Conference on Materials for Advanced Technologies (ICMAT) 3Pittcon 2015 Hits the Big Easy in a Big Way 2Pittcon 2015 Hits the Big Easy in a Big Way 3Pittcon 2015 Hits the Big Easy in a Big Way 4Investment Banker Appointed CEO of Australian Health Tech Start-Up 2Investment Banker Appointed CEO of Australian Health Tech Start-Up 3Bayer HealthCare Expands Collaboration with Broad Institute of MIT and Harvard to Develop Therapies for Cardiovascular Disease 2Bayer HealthCare Expands Collaboration with Broad Institute of MIT and Harvard to Develop Therapies for Cardiovascular Disease 3
Cached News: