HOME >> BIOLOGY >> NEWS
Signal for inflammation linked to Ras-induced tumor growth

Cancer progression is dependent on the ability of tumor cells to interact with and favorably influence their environment. For instance, if a tumor is going expand, it is absolutely critical that new blood vessels are formed so that an adequate blood supply is in place to feed the growing tissue. A new research study published in the November issue of Cancer Cell demonstrates that a cytokine, a chemical signal that stimulates inflammation, plays a critical role in the initiation of new vasculature formation required to promote tumor progression.

Previous research has suggested that there may be a link between cancer-associated angiogenesis and inflammation. The protooncogene Ras has also been implicated in tumor-driven blood vessel generation. Ras is abnormally activated in nearly one quarter of all human cancers and is involved in many aspects of tumor progression, including interactions between tumor cells and the surrounding environment. However, the mechanisms that underlie these interactions are unclear.

Dr. Dafna Bar-Sagi from the Department of Molecular Genetics and Microbiology at the State University of New York at Stony Brook examined whether Ras-mediated induction of the inflammatory mediator CXCL-8 was required for tumor growth and angiogenesis in a mouse model. The researchers found that CXCL-8 production was required for Ras-stimulated tumor inflammation, vascularization, and growth. In addition, inhibition of CXCL-8 function in tumors expressing Ras led to a marked decrease in tumor angiogenesis.

Molecules that modulate CXCL-8 expression are known targets of the Ras signaling pathway, establishing a physiological link between these signaling molecules. The researchers conclude that in response to Ras activation, proinflammatory cytokines such as CXCL-8 may recruit immune cells and endothelial cells to tumor sites, representing a new mechanism for cancer-driven blood vessel generation. According to Dr. Bar-Sagi, "Our findin
'"/>

Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
15-Nov-2004


Page: 1 2

Related biology news :

1. Signaling for cartilage
2. Funnel in the eye: Signal focusing increases photosensitivity
3. Signaling proteins may represent biomarkers for melanoma
4. Signaling protein builds bigger, better bones in mice
5. Penn researchers discover how key protein stops inflammation
6. Gene variations directly link inflammation to an increased risk for lung cancer
7. p53 gene mutations and inflammation trigger skin cancer
8. Remicade data in ankylosing spondylitis show improvement in spinal mobility and spinal inflammation
9. Hot on the TRAIL of controlling inflammation in bacterial meningitis
10. NIAID supports research into etiology of fungal-induced inflammation in chronic sinusitis
11. Omega-3 fatty acids affect risk of depression, inflammation

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Signal for inflammation linked Ras induced tumor growth

(Date:11/4/2014)... In nature, the right amount of death at the ... density, according to new research that could help in ... wildlife stocks. , In a paper in the journal ... University researcher and European colleagues conclude that the kind ... a loss of individuals, or mortality, depends on the ...
(Date:11/4/2014)... --   3D scanner developer ... Fuel3D , a developer of 3D scanning solutions, today ... million (£4 million). This funding builds on the company,s initial ... paves the way for the commercial launch of the company,s ... was led by Chimera Partners and will be used to ...
(Date:11/3/2014)... published in this month,s Proceedings of the ... a recently discovered communication molecule of the body,s immune ... to limit inflammation and the current study reports its ... ability of the immune system to recognize and target ... effect on the immune system now allows us to ...
Breaking Biology News(10 mins):When less is more: Death in moderation boosts population density in nature 2Fuel3D Secures $6.4 Million in Expansion Funding 2Fuel3D Secures $6.4 Million in Expansion Funding 3PNAS: From HIV to cancer, IL-37 regulates immune system 2
(Date:11/26/2014)... 2014 Silicon Valley Electronic Data Capture ... RPM Alliance , provider of clinical research and data ... latest addition to its CRO Partnership Program, Clinovo expands ... to India. , “We have found Clinovo’s ClinCapture ... EDC platform which is both user friendly and easy ...
(Date:11/26/2014)... 2014 SoundConnect , an award ... to announce that Darren Suders has joined the team ... will drive the partner program through innovative ... , Darren brings more than 10-years of channel ... in channel operations, from policy development, to partner education ...
(Date:11/26/2014)... -- Theravalues Corporation annuncia con orgoglio il lancio di ... Hi Europe 2014 (dal 2 al 4 dicembre, ... curcumina con la maggiore biodisponibilità di sempre, con una ... dalle norme europee. La curcumina è un ... Curcuma longa ) che è stata associata con attività ...
(Date:11/24/2014)... Belgium , Nov. 24, 2014 ... focused on developing diagnostic tests for cancer and other conditions, ... will be presented at the Science for Business BioWin Day ... Belgium . The data come from VolitionRx,s lung cancer ... Pneumology department of the Centre Hospitalier Universitaire (CHU) de Liege ...
Breaking Biology Technology:RPM Alliance Joins Clinovo’s CRO Partnership Program, Further Strengthening Its Presence in Southern California and India 2SoundConnect Appoints Director of Channel Development & Sales 2La curcumina con la maggiore biodisponibilità di sempre farà il suo debutto in Europa 2La curcumina con la maggiore biodisponibilità di sempre farà il suo debutto in Europa 3VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 2VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 3VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 4VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 5VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 6
Cached News: