Simple diagnostic test detects genetic signs of lung cancer in a patien...( ining both HYAL2 and FHIT deletions inc...)

Simple diagnostic test detects genetic signs of lung cancer in a patient's sputum

ining both HYAL2 and FHIT deletions increased sensitivity to 76 percent (compared to 46 percent for cytology tests) and the combined probe had a specificity of 92 percent.

The false positive rate of about eight percent occurred because HYAL2 was found in sputum of four cancer-free smokers and FHIT deletions was found in three cancer-free smokers. However, the deletions were not found in the sputum of healthy non-smokers. "Those deletions in cancer-free smokers could represent an early indication that lung cancer is developing that has not yet been detected, but we won't know that without longer follow-up study," Jiang said.

Contact: Greg Lester
lester@aacr.org
267-646-0554
American Association for Cancer Research
18-Jan-2007

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