HOME >> BIOLOGY >> NEWS
Single copy of Parkinson's-risk gene mutation may lead to earlier symptom onset

Mutations in a gene already known to play a role in causing an inherited form of Parkinson disease may also influence the age at which symptoms of the neurological disorder appear. While inheriting two abnormal copies of the parkin gene previously had been associated with the development of early-onset Parkinson's, a new study from a multi-institutional team led by Massachusetts General Hospital (MGH) researchers finds that even a single mutated copy of parkin reduces the age of onset of the disease. The findings appear in the June Archives of Neurology.

"This study reinforces the fact that there are multiple mechanisms behind Parkinson disease and will lead us to examine other pathways with which parkin interacts," says James Gusella, PhD, director of the MGH Center for Human Genetic Research, the study's senior author. The report is part of the larger GenePD project, an international collaborative study of siblings with Parkinson disease, which is based at Boston University Medical Center and led by Richard Myers, PhD.

Parkinson disease is a neurodegenerative disorder characterized by tremors, rigidity, difficulty walking and other symptoms. It is caused by the destruction of brain cells that produce the neurotransmitter dopamine and is the second most common neurodegenerative disorder. The condition's prevalence increases with age appearing in 1 percent of those over 60 and 4 to 5 percent of those over 85 but it can develop in much younger patients. While the cause of most cases of Parkinson's is unknown, there are rare, inherited forms. Five genes have been identified as increasing the risk for Parkinson's parkin mutations inherited from both parents being the most common genetic cause of early-onset disease but additional susceptibility genes are yet to be found.

Since finding new genes is a goal of the GenePD study, a preliminary step is to identify those whose familial Parkinson's can be attributed to one of the known gen
'"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
12-Jun-2006


Page: 1 2 3

Related biology news :

1. Howard C. Berg honored with Outstanding Investigator in Single Molecule Biology Award
2. Single genetic defect causes early heart disease
3. Single molecular mark seen as pivotal for genome compaction in spores and sperm
4. Single genetic assay could help physicians decide when to switch patients from Gleevec to Sutent
5. Single genetic defect produces specific cognitive deficit in mice
6. Single microRNA causes cancer in transgenic mouse
7. Single cell amoeba increases MRSA numbers 1000- fold
8. Single cell recognition research at UCLA/Caltech finds a Halle Berry neuron
9. Single gene is genetic switch for fly sexual behavior
10. Single stem cells from bone heal a broken heart
11. Singled out: Spotting mutant neurons in normal brains offers clues to Fragile X

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/23/2019)... CHICAGO (PRWEB) , ... August 22, 2019 , ... ... by rebranding to Planet121 following their acquisition in June of 2018. Along with ... logo and communications. , “Our goal was to create a cohesive brand ...
(Date:8/21/2019)... (PRWEB) , ... August 20, 2019 , ... ... experience for the second time since BioInformatics first fielded the survey in 2016. ... Life Science Customer Experience , from BioInformatics, part of Science and Medicine Group. ...
(Date:8/15/2019)... ... August 15, 2019 , ... ... what? As serialization mandates become increasingly complex, and aggregation becomes fully applied in ... software is the best long-term solution. , Until now, most regulations?including the Drug ...
Breaking Biology News(10 mins):
(Date:6/11/2019)... ROANOKE, Va. (PRWEB) , ... June 11, 2019 ... ... for microlearning engagement, and Carilion Clinic, a national leader in opioid treatment, announced ... in virtual care. , Mytonomy recently deployed its virtual care platform ...
(Date:6/11/2019)... ... June 11, 2019 , ... A study ... stem cells (MSC-EV) are able to incorporate into human CD34+ cells, modifying their ... mice, MSC-EVs also increased the cells’ ability to lodge into bone marrow. This ...
(Date:5/31/2019)... ... May 29, 2019 , ... For many years, the primary forms ... cancer demand breakthrough therapies. Advances in immuno-oncology have led to the advent of Chimeric ... with engineered T cell receptors known as “CARs”. The CAR enables the final product ...
(Date:5/31/2019)... ... May 30, 2019 , ... World Compliance Seminars today ... 08-09, 2019 in Boston, MA. This peer recommended interactive workshop is always selected ... training will kick off with a compendial treatment of Data Integrity fundamentals. After ...
Breaking Biology Technology:
Cached News: