HOME >> BIOLOGY >> NEWS
Sitagliptin, a new investigational treatment for type 2 diabetes, may offer new hope for patients

There are currently more than 194 million people with diabetes worldwide and this figure could exceed 333 million by 2025 if untreated. [2] Current treatments for type 2 diabetes are often limited by their side effect profile, route of administration or difficulties in sustaining glucose control. [3] As a result, there is a need for better tolerated treatments that do not cause weight gain and produce less risk of hypoglycaemia for patients with type 2 diabetes. The results of the two Phase II studies indicate that sitagliptin, an investigational diabetes drug, appears to control blood sugar with a low incidence of hypoglycaemia and with a neutral effect on body weight.

In the Phase II studies of more than 1,000 patients, ''sitagliptin'', Merck Sharp & Dohme's investigational medicine from a new class of diabetes treatments called dipeptidyl peptidase 4 (DPP-4) inhibitors, improved glycaemic control in patients with type 2 diabetes and exhibited a safety and tolerability profile similar to placebo. In addition, patients taking sitagliptin experienced no significant weight gain and a low risk of hypoglycaemia.

"Results from the studies conducted to date are very promising," said Peter Stein, Senior Director in Clinical Research, Metabolism, Merck Research Laboratories, Rahway, NJ, USA. "The need for well tolerated therapies which achieve better glycaemic control than current therapies is well known and we are confident that these short-term clinical studies demonstrate proof of concept for sitagliptin, offering a new hope for type 2 diabetes patients. Ongoing Phase III trials should provide greater insight into the efficacy and tolerability profile of sitagliptin over a longer period of time".

Study 1: Effect of sitagliptin oral tablets on glycaemic control
Results from a 12-week, double-blind, placebo-controlled, parallel group study in patients with type 2 diabetes showed that sitagliptin oral tablets significantly r
'"/>

Contact: Catherine Pannell
cpannell@hillandknowlton.com
44-207-413-3059
Merck & Co., Inc.
14-Sep-2005


Page: 1 2 3

Related biology news :

1. FUZEON with investigational HIV drug results in remarkable number of patients achieving undetectable
2. Providence health system shows investigational osteoporosis therapy increases bone mineral density
3. Amgen investigational therapy, AMG 162, increased bone mineral density with twice yearly injection
4. New system of wastewater treatment could reduce the size of treatment plants by half
5. UCF research links proteins, stem cells and potential Alzheimers treatment
6. Geisinger scientist seeks cure for Lou Gehrigs disease, creating device to find treatment
7. System to analyze beating heart stem cells could lead to heart attack treatments
8. Gene expression pattern could lead to improved treatment of pediatric septic shock
9. Molecular detectors may refine cancer treatment
10. First genome-wide study of infectious disease opens new avenues for HIV treatment, vaccines
11. A new method of adult stem cell growth efficacious in treatment of disorders of the cornea

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/22/2019)... ... October 21, 2019 , ... Join QPS experts ... Bioanalytical in a live session on Thursday, October 31, 2019 at 11am ... , A good CRO partner should have expertise in method development, which can be ...
(Date:10/22/2019)... ... ... Greenberg Traurig, LLP’s global Life Sciences & Medical Technology Group ... with German biotech strategy consulting firm, Catenion. The seminar will take place from 16:00 ... , Speakers from Greenberg Traurig and Catenion will discuss best practices and practical tips ...
(Date:10/19/2019)... ... October 18, 2019 , ... Scientists from ... and experience the best their field has to offer. PI engineers are on-hand ... industry and research. , Micro- and Nanopositioning Stages for Linear and Rotary Motion, ...
Breaking Biology News(10 mins):
(Date:10/17/2019)... OVERLAND PARK, Kan. (PRWEB) , ... October 15, ... ... rating to 23andMe, a leader among services that offer DNA Testing for health ... become so popular. Everywhere you look, it seems that people want to know ...
(Date:10/10/2019)... ... October 09, 2019 , ... The ... Principal Deputy Commissioner, FDA, as a newly-confirmed keynote speaker for the 2019 ... Vegas, Nevada USA. , Dr. Abernethy, a hematologist/oncologist and palliative medicine physician, is ...
(Date:10/10/2019)... ... October 10, 2019 , ... VirTrial ... research centers in Europe. All Pratia research centers have completed VirTrial’s Virtual Trial ... and certified as Virtual Trial Capable and prepared to conduct decentralized clinical trials ...
(Date:10/8/2019)... BOSTON (PRWEB) , ... October 08, 2019 , ... Today, ... U.K. of its lead development technology. Like the company’s precursor patent, approved in ... and accurate counting of tissue stem cells. Asymmetrex now markets the technology in ...
Breaking Biology Technology:
Cached News: