HOME >> BIOLOGY >> NEWS
Size doesn't matter

In a story reminiscent of David and Goliath, new research from Rockefeller University shows that sometimes the smallest molecules can be the most powerful. In the July 1 issue of Cell, Ulrike Gaul, Ph.D., and colleagues report that microRNAs serve very important, and very specific, functions during the early development of the fruit fly.

First discovered a few years ago, microRNAs are short strings of RNA that are made in large amounts in every cell from plant to humans. Biochemists, including co-author Thomas Tuschl, Ph.D., found that microRNAs bind to messenger RNAs, which are the blueprints for proteins, and either target them for destruction or inhibit them from making proteins.

"There was a lot of beautiful biochemistry showing how microRNAs are made and processed," says Gaul, head of the Laboratory for Developmental Neurogenetics. "But we didn't really know how important they are for the development of an organism and its function."

To solve this question, Gaul and colleagues systematically blocked each of the 46 known microRNAs that are active during early development of the fruit fly. This is difficult to do by traditional genetic means, so they inject young fly embryos with short strings of RNA that bind to the microRNAs and prevent them from finding their target messenger RNAs. The researchers found that over half of the microRNAs were not only essential for development, but also affected it in very specific ways.

"Many of the fundamental processes in development are regulated by microRNAs," Gaul says, "including body patterning, morphogenesis, nervous system and muscle development. In particular, though, we found that cell survival relies very heavily on them."

Cell death in development is not uncommon. The developing embryo makes an overabundance of many cell types, like nerve cells, which it then removes later in a process of fine-tuning. In fact, the genes in flies that carry out a cell's death sentence, Hid, G
'"/>

Contact: Kristine Kelly
kkelly@rockefeller.edu
212-327-7146
Rockefeller University
1-Jul-2005


Page: 1 2 3

Related biology news :

1. Heart intervention doesnt outweigh medicine in study
2. This party doesnt start until the hosts arrive
3. Failed experiment yields a biocontrol agent that doesnt trigger antibiotic resistance
4. High BMI doesnt always spell obesity, Jackson Laboratory researchers show
5. Acetaminophen safe to use after heart attack but doesnt protect the heart
6. In stretching, pain doesnt equal gain; but if NO isnt producing, stretching wont help
7. Study finds evolution doesnt always favor bigger animals
8. If oxytocin eating role doesnt mature at birth, what other situations affect its impact?
9. To sea or not to sea: When it comes to salmon sex, size sometimes doesnt matter
10. What the eye doesnt see
11. Exercise doesnt work for us all

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/28/2017)... The report "Video Surveillance Market ... Storage Devices), Software (Video Analytics, VMS), and Service (VSaaS, ... to 2022", published by MarketsandMarkets, the market was valued ... to reach USD 75.64 Billion by 2022, at a ... year considered for the study is 2016 and the ...
(Date:3/24/2017)... , Mar 24, 2017 Research and ... Access System Market Analysis & Trends - Industry Forecast to 2025" ... ... to grow at a CAGR of around 15.1% over the next ... This industry report analyzes the market estimates and forecasts for all ...
(Date:3/22/2017)... , March 21, 2017   Neurotechnology ... object recognition technologies, today announced the release of ... (SDK), which provides improved facial recognition using up ... on a single computer. The new version uses ... improve accuracy, and it utilizes a Graphing Processing ...
Breaking Biology News(10 mins):
(Date:4/24/2017)... ... April 24, 2017 , ... It is well established ... however, the broad application of this cellular target engagement concept to drug discovery ... Cell-based thermal stabilization assays are valuable methods for particular applications, but they can ...
(Date:4/21/2017)... (PRWEB) , ... April 21, 2017 , ... ... and Webster Bank, today announced first round funding to three startups through the ... early-stage financial support to new business startups affiliated with UConn. , The UConn ...
(Date:4/21/2017)... ... April 21, 2017 , ... Frederick Innovative Technology Center, ... emerging technology-based businesses, recently earned a $77,518 grant from the Rural Maryland Council ... 2004, FITCI is Frederick’s first incubator. A non-profit corporation, FITCI is a public-private ...
(Date:4/20/2017)... ... ... USDM Life Sciences , the leading risk management, technological innovation and ... announce Holger Braemer as Vice President of its Europe division and Managing ... , Braemer is an integral part of USDM’s expansion of services and solutions for ...
Breaking Biology Technology:
Cached News: