HOME >> BIOLOGY >> NEWS
Size doesn't matter

In a story reminiscent of David and Goliath, new research from Rockefeller University shows that sometimes the smallest molecules can be the most powerful. In the July 1 issue of Cell, Ulrike Gaul, Ph.D., and colleagues report that microRNAs serve very important, and very specific, functions during the early development of the fruit fly.

First discovered a few years ago, microRNAs are short strings of RNA that are made in large amounts in every cell from plant to humans. Biochemists, including co-author Thomas Tuschl, Ph.D., found that microRNAs bind to messenger RNAs, which are the blueprints for proteins, and either target them for destruction or inhibit them from making proteins.

"There was a lot of beautiful biochemistry showing how microRNAs are made and processed," says Gaul, head of the Laboratory for Developmental Neurogenetics. "But we didn't really know how important they are for the development of an organism and its function."

To solve this question, Gaul and colleagues systematically blocked each of the 46 known microRNAs that are active during early development of the fruit fly. This is difficult to do by traditional genetic means, so they inject young fly embryos with short strings of RNA that bind to the microRNAs and prevent them from finding their target messenger RNAs. The researchers found that over half of the microRNAs were not only essential for development, but also affected it in very specific ways.

"Many of the fundamental processes in development are regulated by microRNAs," Gaul says, "including body patterning, morphogenesis, nervous system and muscle development. In particular, though, we found that cell survival relies very heavily on them."

Cell death in development is not uncommon. The developing embryo makes an overabundance of many cell types, like nerve cells, which it then removes later in a process of fine-tuning. In fact, the genes in flies that carry out a cell's death sentence, Hid, G
'"/>

Contact: Kristine Kelly
kkelly@rockefeller.edu
212-327-7146
Rockefeller University
1-Jul-2005


Page: 1 2 3

Related biology news :

1. Heart intervention doesnt outweigh medicine in study
2. This party doesnt start until the hosts arrive
3. Failed experiment yields a biocontrol agent that doesnt trigger antibiotic resistance
4. High BMI doesnt always spell obesity, Jackson Laboratory researchers show
5. Acetaminophen safe to use after heart attack but doesnt protect the heart
6. In stretching, pain doesnt equal gain; but if NO isnt producing, stretching wont help
7. Study finds evolution doesnt always favor bigger animals
8. If oxytocin eating role doesnt mature at birth, what other situations affect its impact?
9. To sea or not to sea: When it comes to salmon sex, size sometimes doesnt matter
10. What the eye doesnt see
11. Exercise doesnt work for us all

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Size doesn matter

(Date:10/16/2014)... 2014) – Post-menopausal women experienced improvements in vaginal ... or genital bleeding, after 12 weeks of daily ... soy germ-based nutritional supplement previously shown to help ... peer-reviewed pilot study reported in a poster at ... meeting. , "These data documented improved vaginal ...
(Date:10/15/2014)... PORT WASHINGTON, N.Y. , Oct. 15, 2014 ... in technology solutions for home and community-based care, ... the benefits of implementing Sandata,s Santrax® Electronic Visit ... Quality Care Services is a home health company ... Texas . ...
(Date:10/15/2014)... is a non-traditional biophysics textbook and it describes how ... journey of discovery into biological systems and provides an ... It is about how our genes make proteins that ... of cells in an organism. It quantifies the principles ... can be found on both large and small scales. ...
Breaking Biology News(10 mins):S-equol supplements associated with improved measures of reproductive health in postmenopausal women 2Sandata Announces Case Study with Quality Care Services, Inc. 2New book about life as seen from physics 2
(Date:10/18/2014)... The report "1,6-Hexanediol Market by ... to 2019", analyzes the global market on the ... the industry details such as the key drivers, ... regions. , Browse 81 Market Data Tables and ... TOC on “1,6-Hexanediol Market by Application and by ...
(Date:10/18/2014)... The Asian Electronic Medical Record (EMR) market report defines ... forecast of revenue. The electronic medical record market in the ... 2018, at a CAGR of 9.4% from 2013 to 2018. ... Record (EMR) market, to get an idea of the in-depth ... of the market in the same region, and is supported ...
(Date:10/18/2014)... (PRWEB) October 18, 2014 The ... Stress, Holter Monitor), by End-user (Hospitals, Home/Ambulatory, Research ... (Single, 3-6, 12) -Global Forecast to 2020” provides ... challenges, opportunities, current market trends, and strategies impacting ... estimates and forecasts of the revenue and share ...
(Date:10/17/2014)... 17, 2014 For the seventh ... as published in today’s print issue of Science ... Top Employers Survey polled employees in the biotechnology, ... best employers. Rankings were determined based on ... rate their companies on 23 characteristics, including financial ...
Breaking Biology Technology:1,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 21,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 31,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 41,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 5The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 2The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 3The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 4The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 5The Electrocardiograph (ECG) Market Is Expected to Reach $5,435 Million By 2020 - New Research Report by MarketsandMarkets 2The Electrocardiograph (ECG) Market Is Expected to Reach $5,435 Million By 2020 - New Research Report by MarketsandMarkets 3The Electrocardiograph (ECG) Market Is Expected to Reach $5,435 Million By 2020 - New Research Report by MarketsandMarkets 4The Electrocardiograph (ECG) Market Is Expected to Reach $5,435 Million By 2020 - New Research Report by MarketsandMarkets 5DuPont Named Top Employer by Science Magazine 2DuPont Named Top Employer by Science Magazine 3
Cached News: