HOME >> BIOLOGY >> NEWS
Size doesn't matter

In a story reminiscent of David and Goliath, new research from Rockefeller University shows that sometimes the smallest molecules can be the most powerful. In the July 1 issue of Cell, Ulrike Gaul, Ph.D., and colleagues report that microRNAs serve very important, and very specific, functions during the early development of the fruit fly.

First discovered a few years ago, microRNAs are short strings of RNA that are made in large amounts in every cell from plant to humans. Biochemists, including co-author Thomas Tuschl, Ph.D., found that microRNAs bind to messenger RNAs, which are the blueprints for proteins, and either target them for destruction or inhibit them from making proteins.

"There was a lot of beautiful biochemistry showing how microRNAs are made and processed," says Gaul, head of the Laboratory for Developmental Neurogenetics. "But we didn't really know how important they are for the development of an organism and its function."

To solve this question, Gaul and colleagues systematically blocked each of the 46 known microRNAs that are active during early development of the fruit fly. This is difficult to do by traditional genetic means, so they inject young fly embryos with short strings of RNA that bind to the microRNAs and prevent them from finding their target messenger RNAs. The researchers found that over half of the microRNAs were not only essential for development, but also affected it in very specific ways.

"Many of the fundamental processes in development are regulated by microRNAs," Gaul says, "including body patterning, morphogenesis, nervous system and muscle development. In particular, though, we found that cell survival relies very heavily on them."

Cell death in development is not uncommon. The developing embryo makes an overabundance of many cell types, like nerve cells, which it then removes later in a process of fine-tuning. In fact, the genes in flies that carry out a cell's death sentence, Hid, G
'"/>

Contact: Kristine Kelly
kkelly@rockefeller.edu
212-327-7146
Rockefeller University
1-Jul-2005


Page: 1 2 3

Related biology news :

1. Heart intervention doesnt outweigh medicine in study
2. This party doesnt start until the hosts arrive
3. Failed experiment yields a biocontrol agent that doesnt trigger antibiotic resistance
4. High BMI doesnt always spell obesity, Jackson Laboratory researchers show
5. Acetaminophen safe to use after heart attack but doesnt protect the heart
6. In stretching, pain doesnt equal gain; but if NO isnt producing, stretching wont help
7. Study finds evolution doesnt always favor bigger animals
8. If oxytocin eating role doesnt mature at birth, what other situations affect its impact?
9. To sea or not to sea: When it comes to salmon sex, size sometimes doesnt matter
10. What the eye doesnt see
11. Exercise doesnt work for us all

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/23/2017)... , Jan. 23, 2017  The latest mobile ... smartphone prices have dropped dramatically. The quarterly average price ... 2013 to $276 in Q4 2016.  There are now ... price of $116, up from just 28 a year ... According to Maxine Most , Acuity Market ...
(Date:1/19/2017)... 2017 Sensory Inc ., a ... for consumer electronics, and i nnerCore ... cybersecurity solutions, today announced a global partnership that ... worldwide to bolster security of data sensitive mobile ... authentication platforms they offer, innerCore now offers its ...
(Date:1/13/2017)... Jan. 13, 2017 Sandata Technologies, LLC, ... the homecare industry, including Electronic Visit Verification™ (EVV™), ... Justin Jugs, as Senior Vice President of Product ... years of homecare experience to Sandata, where he ... plans to align Sandata,s suite of solutions with ...
Breaking Biology News(10 mins):
(Date:2/22/2017)... , Feb 22, 2017 ... of the "Global Biological Crop Protection (Bio-Pesticide) Market-By Type, By ... (2016-2021)" report to their offering. ... Global Biological Crop Protection Market is forecasted ... The strong growth in biopesticide or biological crop protection market ...
(Date:2/22/2017)... 2017 Aethlon Medical, Inc. (Nasdaq: ... that validated the ability of the Aethlon Hemopurifier® to ... mortality in immune-suppressed sepsis patients and also contribute to ... objective of the study was to validate the ... (EBV) and Herpes Simplex virus 1 (HSV1) by the ...
(Date:2/22/2017)... ... February 22, 2017 , ... Pharma and biotech ... as European director. Operating from Pennside’s Zurich headquarters, Pennside Partners, GmbH, Mr. Perkins ... Pennside after more than a decade with leading market research firm, GfK. He ...
(Date:2/22/2017)... TRIANGLE PARK, N.C., Feb. 22, 2017  United Therapeutics ... its financial results for the fourth quarter and ... 2016 financial results reflect continued growth as net ... million," said Martine Rothblatt, Ph.D., United Therapeutics, Chairman ... our ability to develop and advance our growing ...
Breaking Biology Technology:
Cached News: