HOME >> BIOLOGY >> NEWS
Size doesn't matter

rim and Reaper, are expressed in many healthy cells, poised to do their job at a moment's notice.

Gaul's new research shows that it is microRNAs that stand between a cell's survival and its death at the hands of Hid, Grim and Reaper. The microRNAs bind to the messenger RNA of the death genes and prevent their proteins from being made. But when the microRNAs are blocked, Hid, Grim and Reaper proteins are produced, causing massive cell death and killing the fly embryo.

The microRNAs that block cell death all belong to the largest microRNA family in the fruit fly. The family is made up of 13 members, which are identical in sequence at one end but different at the other. There has been some debate on whether differences at this end are important, but Gaul's research now shows that they are central for helping the microRNAs find the right targets.

"Our findings show that while similar defects are seen when the different family members are blocked, they are not identical," Gaul says. "And we find that different family members interact differently with the three death genes."

Deciding between life and death is only one of many split-second decisions that a cell may have to make. By regulating which messenger RNAs are used to make protein, microRNAs can help cells react to an event without the nucleus being involved. For example, the ending of a nerve cell can be very far away from its nucleus. Localizing and regulating messenger RNAs at the nerve endings enables the nerves to react very fast to an incoming signal, instead of every signal being transmitted to the nucleus and back.

Gaul's lab has many more interesting microRNAs to examine, a number of which are conserved between flies and humans. The next experiments will look to further match up different microRNAs with their targets. But Gaul is also very interested in how microRNAs themselves are regulated.

"We wanted to know if microRNAs were important and if they were s
'"/>

Contact: Kristine Kelly
kkelly@rockefeller.edu
212-327-7146
Rockefeller University
1-Jul-2005


Page: 1 2 3

Related biology news :

1. Heart intervention doesnt outweigh medicine in study
2. This party doesnt start until the hosts arrive
3. Failed experiment yields a biocontrol agent that doesnt trigger antibiotic resistance
4. High BMI doesnt always spell obesity, Jackson Laboratory researchers show
5. Acetaminophen safe to use after heart attack but doesnt protect the heart
6. In stretching, pain doesnt equal gain; but if NO isnt producing, stretching wont help
7. Study finds evolution doesnt always favor bigger animals
8. If oxytocin eating role doesnt mature at birth, what other situations affect its impact?
9. To sea or not to sea: When it comes to salmon sex, size sometimes doesnt matter
10. What the eye doesnt see
11. Exercise doesnt work for us all

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... N.Y. , April 11, 2017 ... fingerprints, but researchers at the New York University ... College of Engineering have found that partial similarities ... security systems used in mobile phones and other ... thought. The vulnerability lies in the ...
(Date:4/5/2017)... YORK , April 5, 2017 Today ... is announcing that the server component of the HYPR ... known for providing the end-to-end security architecture that empowers ... HYPR has already secured over 15 million ... makers including manufacturers of connected home product suites and ...
(Date:3/30/2017)... LOS ANGELES , March 30, 2017  On ... Hack the Genome hackathon at ... This exciting two-day competition will focus on developing health ... experience. Hack the Genome is ... has been tremendous. The world,s largest companies in the ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... October 10, 2017 , ... ... company advancing targeted antibody-drug conjugate (ADC) therapeutics, today confirmed licensing rights that ... Polymerized Liposomal Nanoparticle), a technology developed in collaboration with Children’s Hospital Los ...
(Date:10/10/2017)... Oct. 10, 2017 SomaGenics announced the receipt ... to develop RealSeq®-SC (Single Cell), expected to be the ... RNAs (including microRNAs) from single cells using NGS methods. ... need to accelerate development of approaches to analyze the ... "New techniques for measuring levels of mRNAs in ...
(Date:10/9/2017)... ... ... The award-winning American Farmer television series will feature 3 Bar Biologics in ... 8:30aET on RFD-TV. , With global population estimates nearing ten billion people by ... feed a growing nation. At the same time, many of our valuable resources are ...
(Date:10/7/2017)... Phoenix, Arizona (PRWEB) , ... ... ... than 15 years’ experience providing advanced instruments and applications consulting for microscopy ... the in-house expertise in application consulting, Nanoscience Analytical offers a broad range ...
Breaking Biology Technology:
Cached News: