Size doesn't matter

rim and Reaper, are expressed in many healthy cells, poised to do their job at a moment's notice.

Gaul's new research shows that it is microRNAs that stand between a cell's survival and its death at the hands of Hid, Grim and Reaper. The microRNAs bind to the messenger RNA of the death genes and prevent their proteins from being made. But when the microRNAs are blocked, Hid, Grim and Reaper proteins are produced, causing massive cell death and killing the fly embryo.

The microRNAs that block cell death all belong to the largest microRNA family in the fruit fly. The family is made up of 13 members, which are identical in sequence at one end but different at the other. There has been some debate on whether differences at this end are important, but Gaul's research now shows that they are central for helping the microRNAs find the right targets.

"Our findings show that while similar defects are seen when the different family members are blocked, they are not identical," Gaul says. "And we find that different family members interact differently with the three death genes."

Deciding between life and death is only one of many split-second decisions that a cell may have to make. By regulating which messenger RNAs are used to make protein, microRNAs can help cells react to an event without the nucleus being involved. For example, the ending of a nerve cell can be very far away from its nucleus. Localizing and regulating messenger RNAs at the nerve endings enables the nerves to react very fast to an incoming signal, instead of every signal being transmitted to the nucleus and back.

Gaul's lab has many more interesting microRNAs to examine, a number of which are conserved between flies and humans. The next experiments will look to further match up different microRNAs with their targets. But Gaul is also very interested in how microRNAs themselves are regulated.

"We wanted to know if microRNAs were important and if they were s

Contact: Kristine Kelly
Rockefeller University

Page: 1 2 3

Related biology news :

1. Heart intervention doesnt outweigh medicine in study
2. This party doesnt start until the hosts arrive
3. Failed experiment yields a biocontrol agent that doesnt trigger antibiotic resistance
4. High BMI doesnt always spell obesity, Jackson Laboratory researchers show
5. Acetaminophen safe to use after heart attack but doesnt protect the heart
6. In stretching, pain doesnt equal gain; but if NO isnt producing, stretching wont help
7. Study finds evolution doesnt always favor bigger animals
8. If oxytocin eating role doesnt mature at birth, what other situations affect its impact?
9. To sea or not to sea: When it comes to salmon sex, size sometimes doesnt matter
10. What the eye doesnt see
11. Exercise doesnt work for us all

Post Your Comments:

(Date:11/12/2015)... golden retriever that stayed healthy despite having the gene ... new lead for treating this muscle-wasting disorder, report scientists ... and Harvard and the University of São Paolo in ... pinpoints a protective gene that boosts muscle regeneration, ... Children,s lab of Lou Kunkel , PhD, is ...
(Date:11/10/2015)... Nov. 10, 2015 About ... that helps to identify and verify the identity ... considered as the secure and accurate method of ... a particular individual because each individual,s signature is ... especially when dynamic signature of an individual is ...
(Date:10/29/2015)... Oct. 29, 2015   MedNet Solutions , an ... spectrum of clinical research, is pleased to announce that ... Association (MHTA) as one of only three finalists for ... – Small and Growing" category. The Tekne Awards honor ... shown superior technology innovation and leadership. ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... LUMPUR, Malaysia , Nov. 24, 2015 /PRNewswire/ ... global contract research organisation (CRO) market. The trend ... result in lower margins but higher volume share ... increased capacity and scale, however, margins in the ... Research Organisation (CRO) Market ( http://www.frost.com/sublib/display-report.do?id=P86A-01-00-00-00&src=PR ), ...
(Date:11/24/2015)... 2015 Halozyme Therapeutics, Inc. (NASDAQ: HALO ) will ... New York on Wednesday, December 2 at 9:30 a.m. ... and CEO, will provide a corporate overview. th ... at 1:00 p.m. ET/10:00 a.m. PT . Jim Mazzola ... a corporate overview. --> th Annual Oppenheimer Healthcare ...
(Date:11/24/2015)... ... November 24, 2015 , ... ... the year and one of the premier annual events for pharmaceutical manufacturing: 2015 ... 8–11 November 2015, where ISPE hosted the largest number of attendees in more ...
(Date:11/24/2015)... 2015 --> ... "Oligonucleotide Synthesis Market by Product & Services (Primer, Probe, ... DNA, RNAi), End-User (Research, Pharmaceutical & Biotech, Diagnostic Labs) ... market is expected to reach USD 1,918.6 Million by ... CAGR of 10.1% during the forecast period. ...
Breaking Biology Technology:
Cached News: