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Sleep apnea increases risk of diabetes and hypertension in pregnant women

ATS 2007, SAN FRANCISCOSleep apnea is associated with a greatly increased incidence of pregnancy-induced diabetes and high blood pressure, according to a study presented at the American Thoracic Society 2007 International Conference, on Wednesday, May 22.

The study found that when the womens weight was taken into account, sleep apnea was associated with a doubling of the incidence of gestational diabetes and a fourfold increase in the risk of pregnancy-induced hypertension.

In obstructive sleep apnea, the upper airway narrows, or collapses, during sleep. Periods of apnea end with a brief partial arousal that may disrupt sleep hundreds of times a night. Obesity is a major risk factor for sleep apnea.

The most effective treatment for sleep apnea is an apparatus called nasal CPAP, for continuous positive airway pressure, which delivers air through a mask while the patient sleeps, keeping the airway open.

The researchers analyzed data from all pregnancies associated with sleep apnea, gestational diabetes (women who developed diabetes during pregnancy) and pregnancy-induced high blood pressure nationwide in 2003. Out of almost 4 million deliveries, 452 had sleep apnea. Of the 167,227 women who had gestational diabetes, 67 had sleep apnea. Of the 200,902 pregnancies with pregnancy-induced high blood pressure, 166 had sleep apnea.

The repetitive decrease in oxygen that occurs during the night in someone with sleep apnea heightens the bodys fight or flight state, which can raise blood pressure, explains researcher Hatim Youssef, D.O. of UMDNJ-Robert Wood Johnson Medical School. The body also secretes more hormones such as cortisol and epinephrine, and the body responds by producing more glucose coupled with a decreased sensitivity to insulin, which can lead to diabetes.

Pregnancy can worsen sleep apnea, especially during the third trimester when a womans weight is greatest, Dr. Youssef explains. When a mothers oxygen level drops at ni
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Contact: Suzy Martin
smartin@thoracic.org
212-315-8631
American Thoracic Society
22-May-2007


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