HOME >> BIOLOGY >> NEWS
Sleepless for science: Flies show link between sleep, immune system in Stanford study

STANFORD, Calif. - Go a few nights without enough sleep and you're more likely to get sick, but scientists have no real explanation for how sleep is related to the immune system. Now, researchers at the Stanford University School of Medicine are finding that fruit flies can point to the answers.

What they have learned thus far is that illness and sleep disruption may be a two-way street: sick flies can't sleep, and losing sleep makes them more susceptible to infection.

"When flies get sick, they stop sleeping," said David Schneider, PhD, assistant professor of microbiology and immunology. "Disrupting sleep in turn disrupts the immune system, which makes them even more infected and it's downhill from there in a 'spiral of death.'" Schneider is the senior author of a study on the sleep patterns of flies that will be published in the May 15 issue of Current Biology.

Schneider worked with postdoctoral scholar Mimi Shirasu-Hiza, PhD, who is the study's first author, to examine the connection between illness and sleep patterns by infecting fruit flies with one of two bacteria - Streptococcus pneumoniae or Listeria monocytogenes.

The infected flies lost their "day" and "night" patterns of activity, which are part of the regular changes that occur in the course of a day, called circadian rhythm. Uninfected flies alternate between 12 hours of high activity and 12 hours of low activity. The researchers found the sick flies had fewer sleep sessions and shorter periods of continuous sleep than did healthy flies. They basically just didn't sleep well, concluded the researchers.

The researchers can't say for sure say whether a disruption of the brain's central clock, which is the area of the fly brain that exhibits circadian gene activity, was responsible for the changes seen in the sick flies. But the behavior of the ill flies looked a lot like that of flies known to have disruptions in their genes controlling circadian rhyth
'"/>

Contact: Mitzi Baker
mabaker@stanford.edu
650-725-2106
Stanford University Medical Center
14-May-2007


Page: 1 2 3

Related biology news :

1. Gateway to Nanoscience: The convergence of disciplines
2. The sweet science: Viruses switch grip to gain upper hand
3. Feb. 17 sipping science: An evening of red wine tasting and wine science
4. Flies dont buzz about aimlessly!
5. Flies on speed offer insight into the roles of dopamine in sleep and arousal
6. Flies on crack
7. Flies have morning and evening clocks
8. New textbook illuminates the close links between evolutionary and molecular biology
9. Link between sunspots, rain helps predict disease in east Africa
10. Link identified between Alzheimers disease and glaucoma
11. Teamwork between 2 key proteins necessary for normal development and regulation of red blood cells

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/4/2020)... ... July 03, 2020 , ... Aesthetics Biomedical (ABM), a ... awards for not only the products and treatments developed, but also the dedicated ... RF. All the brands built by ABM have received several honors already for ...
(Date:7/1/2020)... ... July 01, 2020 , ... Cure Glioblastoma, ... glioblastoma—the most common and aggressive adult brain cancer—announced today the appointments of its ... are charged with supporting the organization’s initiatives and overall vision. , "Senior Fellows ...
(Date:6/23/2020)... ... June 23, 2020 , ... ... services, today announced that the company has received ISO9001:2015 certification for the ... and research industries. The decision to pursue ISO9001 accreditation demonstrates Kemp’s commitment ...
Breaking Biology News(10 mins):
(Date:8/15/2020)... ... August 13, 2020 , ... ... Inc. 5000 list, the most prestigious ranking of the nation’s fastest-growing private companies. ... American economy’s most dynamic segment—its independent small businesses. Intuit, Zappos, Under Armour, Microsoft, ...
(Date:8/12/2020)... HOUSTON (PRWEB) , ... August ... ... a biopharmaceutical cold chain validation engineering firm, is making available for ... driving the need to incorporate concurrent transport simulation testing into today’s biologics ...
(Date:8/7/2020)... ... August 06, 2020 , ... VGXI, a highly regarded CDMO ... the purchase of greenfield for a new, expanded manufacturing facility. The site is ... in the initial acquisition, with an option to purchase an additional 21 acres ...
(Date:8/3/2020)... ... August 03, 2020 , ... Introducing Ardent Animal Health ... growth, , Known as MediVet Biologics since its formation in ... The new Ardent Animal Health will build on its base of innovative therapies ...
Breaking Biology Technology:
Cached News: