HOME >> BIOLOGY >> NEWS
Sleepy fruit flies provide clues to learning and memory

(Philadelphia, PA) Researchers at the University of Pennsylvania School of Medicine have discovered that a brain region previously known for its role in learning and memory also serves as the location of sleep regulation in fruit flies. Through further examination of this brain structure, researchers hope to shed light on sleep regulation and its role in memory.

Despite its importance in everyday human function, very little is known about the regulation of sleep. In search of the underlying brain region responsible for sleep regulation, senior author Amita Sehgal, PhD, Professor of Neuroscience and a Howard Hughes Medical Institute (HHMI) Investigator, and colleagues turned their attention to the fruit fly.

"Fruit flies and humans share similar resting patterns," explains Sehgal. "Like humans, the sleeping states of fruit flies are characterized by periods of immobility over a twenty-four hour period, during which the fruit flies demonstrate reduced responsiveness to sensory stimuli."

By tinkering with the gene expression of multiple regions of the fruit fly brain, the research team was able to zero in on the adult mushroom body as the sleep center of the brain. They reported their findings in last week's issue of Nature.

To locate the brain region involved in sleep regulation, Sehgal manipulated the activity of an enzyme known as protein kinase A (PKA). Previous work in Sehgal's lab revealed that the higher the level of PKA activity, the lower the period of immobility, or sleep, in the fruit fly. By building upon this work, Sehgal and others set out to increase PKA activity in various regions of the brain and examine the subsequent sleeping patterns in the fruit flies. "Sleeping fruit flies" were defined as those that remained immobile for at least five minutes.

"From the beginning, we took the unbiased approach," explains Sehgal. "We targeted PKA activity to different areas of the fly brain to find out where PKA acts to
'"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
15-Jun-2006


Page: 1 2 3

Related biology news :

1. Native fruits bear sweet antioxidants
2. Super fruit fly may lead to healthier humans
3. Do fruit flies have free will?
4. Berkeley Lab Life Sciences division awarded NIH grants for fruit fly, nematode studies
5. Similar brain chemicals influence aggression in fruit flies and humans
6. Researcher focuses on pros, cons of antioxidants from fruits and vegetables
7. Neighbors gone, fruits gone, species gone
8. A frenzy of fruit fly methods featured in Cold Spring Harbor Protocols
9. Why migrate? Its not for the fruit
10. Fatal attraction: Elephants and marula fruit
11. Researchers find link between food odors and lifespan in fruit flies

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/11/2020)... ... February 11, 2020 , ... ... problems for life sciences companies and government agencies, announced the recent appointment ... consulting expertise to Tunnell, with significant experience assessing, designing, and managing enterprise ...
(Date:2/6/2020)... ... February 06, 2020 , ... Kerafast Inc. ... bioresearch materials, today announced an agreement with The Good Food Institute , ... reality. Under the partnership, terrestrial meat and aquatic cell lines will be made ...
(Date:1/29/2020)... (PRWEB) , ... January 29, 2020 , ... ... lead the new Analytics and Data Sciences practice, providing consulting services for strategy, ... appointment was announced by Mike Townley, co-founder and Managing Partner of CREO, an ...
Breaking Biology News(10 mins):
(Date:2/11/2020)... ... February 11, 2020 , ... Synagro Technologies, ... America, today announced that the City of Fort Worth has partnered with Synagro ... Commencing in April of 2020, Synagro will assume operation of the city’s current ...
(Date:2/3/2020)... ... February 03, 2020 , ... Global molecular diagnostics ... OmniType, the 11-locus, single tube multiplex successor to Holotype HLA is available through ... locus-multiplexing and short library preparation, for HLA genotyping from sample to answer in ...
(Date:1/27/2020)... ... January 27, 2020 , ... ... secured financing from strategic investors led by Halma plc , a FTSE ... Sonion, TDF Ventures, GII LLC, and WSJ Joshua Fund. A representative from Halma ...
(Date:1/22/2020)... SAN MATEO, Calif. (PRWEB) , ... January 20, ... ... Home System, today announced a partnership with WAVE Electronics, the largest independent electronics ... their installer partners to purchase Brilliant Smart Home Systems with leading smart home ...
Breaking Biology Technology:
Cached News: