HOME >> BIOLOGY >> NEWS
Sniffing out the culprits of dust allergies

There is increasing evidence suggesting that allergic-response diseases such as asthma, perennial rhinitis, and atopic dermatitis result from proteolytic or other enzymatic activity in common allergens. Dust is commonly allergenic, and to investigate the presence of active proteases in dust, researchers led by Jennifer Harris at The Scripps Research Institute and Nicolas Winssinger at the Universit Louis Pasteur examined an extract derived from dust mites. The researchers devised and used a novel combined-library approach for this purpose--a method that enabled simultaneous identification of proteases from complex samples and isolation of protease-specific inhibitors. In this way, Der 1 p was identified as an active cysteine protease in dust mite extracts, and a Der 1 p-specific small-molecule inhibitor was isolated from a peptide nucleic acid (PNA)-encoded small-molecule library. As a result of this investigation, Der 1 p was implicated in the cleavage of the CD4+ T cell receptor CD25--the Der 1 p inhibitor has a dose-dependent ability to protect the receptor on whole cells. This study demonstrates the utility of this new approach for quickly identifying active proteases involved in allergic responses or other disease processes and effective inhibitors that can be further developed for diagnostic or therapeutic research.

Nicolas Winssinger, Robert Damoiseaux, David C. Tully, Bernhard H. Geierstanger, Keith Burdick, and Jennifer L. Harris: "PNA-Encoded Protease Substrate Microarrays"

Jennifer Harris, Daniel E. Mason, Jun Li, Keith W. Burdick, Bradley J. Backes, Teresa Chen, Aaron Shipway, Gino Van Heeke, Lucy Gough, Amir Ghaemmaghami, Farouk Shakib, Francois Debaene, and Nicolas Winssinger: "Activity Profile of Dust Mite Allergen Extract Using Substrate Libraries and Functional Proteomic Microarrays"


'"/>

Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
15-Oct-2004


Page: 1

Related biology news :

1. Sniffing out relatives, bluegill sunfish use self-referencing to recognize kin
2. Dipstick test for meningitis culprits
3. Pollution trackers hit the road to pinpoint airborne culprits
4. Forsyth scientists find blue light fights gum disease culprits
5. Peanut allergies overstated, study finds
6. Early exposure to indoor fungus molecules may protect infants against future allergies
7. Non-GMO solution to seafood allergies
8. White blood cells in lung produce histamine seen in allergies
9. Potential new therapeutic target for asthma, allergies and cancer
10. Friendly bacteria in alcoholic milkshake could fight food allergies
11. Tests may help answer questions about GMOs and allergies

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/19/2019)... , ... November 19, 2019 , ... Hosted at the ... , MJBizCon 2019 is the largest gathering of MJBiz business professionals in ... and programming to benefit every sector, there is no show quite like it. Atlantic ...
(Date:11/14/2019)... ... ... Personalized Stem Cells, Inc (“PSC”), a human adipose-derived stem cell ... for stem cell treatment of knee osteoarthritis . The first treatment came shortly after ... Biopharma. , In July of 2019, PSC received FDA approval for a ...
(Date:11/12/2019)... ... November 12, 2019 , ... ... leader in the design and manufacturer of technical ergonomic seating solutions, announced ... footrests compliant with Healthier Hospital Initiative guidelines. Established by Practice Greenhealth, a ...
Breaking Biology News(10 mins):
(Date:11/22/2019)... ... ... Lajollacooks4u is preparing for another busy holiday season. Not only has ... popular cooking classes and team-building events, but the company has also booked numerous companies ... a favorite for companies of all sizes since 2008. Each event is completely ...
(Date:11/12/2019)... , ... November 12, 2019 , ... ... solutions for the food and beverage industry launched a new innovative website. , ... digital experience. Now, the website offers global visitors updated ingredient usage tables by ...
(Date:11/6/2019)... ... 2019 , ... LeadingBiotech ,?an exclusive event series bringing ... East/West CEO conference to be held January 11-12, 2020 at the ... week of the J.P. Morgan Healthcare Conference and other biotech industry conferences, collectively ...
(Date:11/2/2019)... ... October 31, 2019 , ... Join ... in a live webinar on Friday, November 15, 2019 at 1pm ... Immunosequencing, the science of profiling T-cell receptors (TCRs) and B-cell receptors (BCRs), has ...
Breaking Biology Technology:
Cached News: