HOME >> BIOLOGY >> NEWS
Software, evolution and micro-inversions -- improving the building of phylogenetic trees

Biologists will be able to reconstruct the process of evolution, determine relationships between species and build phylogenetic trees with greater accuracy thanks to a new method for identifying microinversions, which are extremely short strings of inverted nucleotides.

This new work from researchers at UC San Diego and Brown University will appear in the online version of PNAS on December 18, 2006.

Microinversions usually tens to thousands of base pairs in length can only be detected if you have the exact nucleotide sequence of the same genomic region for all the species you are considering. Many recent studies have pointed to microinversions as large sources of genetic diversity that have not previously been characterized, and the new research from UCSD provides a more careful and accurate approach to identifying microinversions.

As more fine-grained genomic data becomes available, microinversions will be increasingly important in understanding genetic diversity both between and within species, said Mark Chaisson, the first author on the paper and a Bioinformatics Ph.D. student from UCSDs Jacobs School of Engineering.

This method might be able to provide evidence for the entire mammalian phylogeny, such as the presence of an afrotheria clade, he said.

Using data from their microinversion detection technique an open-source software system called InvChecker the researchers reconstructed the phylogenetic tree for 15 mammals. This work largely confirmed the existing phylogenetic tree that connects these mammals.

Three years ago, we didnt know microinversions existed, explained Pevzner. When they were discovered, there was a lot of skepticism. In the last year, scientists have discovered just how common they are in evolution even in variation between humans, which is why they are such a hot topic today.

Weve only looked for microinversions in 0.1 percent of the genomic sequence from several mammals, and we ca
'"/>

Contact: Daniel Kane
dbkane@ucsd.edu
858-534-3262
University of California - San Diego
18-Dec-2006


Page: 1 2 3

Related biology news :

1. Clones on task serve greater good, evolutionary study shows
2. New textbook illuminates the close links between evolutionary and molecular biology
3. Coelacanth fossil sheds light on fin-to-limb evolution
4. Genomics study provides insight into the evolution of unique human traits
5. New proteomics research promises to revolutionize biomedical discovery
6. Species detectives track unseen evolution
7. Study identifies energy efficiency as reason for evolution of upright walking
8. Clues to future evolution of HIV come from African green monkeys
9. Tumor painting revolutionizes fight against cancer
10. Revolutionary global environment fund announces $50M expansion
11. A first-principles model of early evolution

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/1/2019)... ... 31, 2019 , ... Advancements with Ted Danson to focus ... information. , Factor Bioscience Inc. (Factor) is pioneering nucleic-acid and cell-based technologies to ... segment of Advancements will explore how Factor Bioscience is building the future of ...
(Date:7/24/2019)... ... July 24, 2019 , ... NDA ... a quality assurance expert with more than 20 years of experience working in ... has joined the firm as an Expert Consultant. , Dr. Hartzfeld has experience ...
(Date:7/21/2019)... ... July 20, 2019 , ... ... ) announced today the release of the biggest software update in its ... platform will provide a significant increase in productivity for its users. ...
Breaking Biology News(10 mins):
(Date:7/17/2019)... ... July 16, 2019 , ... Quidel is the market ... Information. Abbott, Roche and Siemens Healthineers and Response Biomedical also are among the ... Market for Point-of-Care (POC) Diagnostics . , Quidel is a market leader in ...
(Date:7/9/2019)... ... 2019 , ... Balluff has been named a 2019 “Best ... Innovative Product of the Year which highlights cutting-edge advancements and achievements that are ... & Conference 2019, held this week in San Jose, California. , Utilizing ...
(Date:6/18/2019)... YORK and SOMERSET, N.J. (PRWEB) , ... June ... ... Catalent Biologics, today announced that they have entered into an agreement for production ... product candidates, IC-100 for the treatment of rhodopsin-mediated autosomal dominant retinitis pigmentosa (RHO-adRP) ...
(Date:6/11/2019)... ... 2019 , ... Thought Technology Ltd is pleased to announce ... Tech Ltd as its authorised distributor for the UK and Ireland. , ... and clinical assessment protocols to treat stress related disorders as well as provide ...
Breaking Biology Technology:
Cached News: