Soil-bound prions that cause CWD remain infectious

Madison -Scientists have confirmed that prions, the mysterious proteins thought to cause chronic wasting disease (CWD) in deer, latch on tightly to certain minerals in soil and remain infectious.

The discovery that prions stay deadly despite sticking to soil comes as a surprise, because while many proteins can bind to soil, that binding usually changes their shapes and activities.

In a paper published in the journal PLoS Pathogens (April 14), scientists at the University of Wisconsin-Madison suggest that certain soil types serve as natural prion repositories in the wild. As animals regularly consume soil to meet their mineral needs, it's possible that prion-laden soil particles contribute to the transmission of prion disease such as CWD among animals.

CWD is a fatal, incurable condition that belongs to a family of prion-inflicted neurological disorders known as transmissible spongiform encephalopathies (TSE). Other TSEs include "mad cow" disease, sheep scrapie and Creutzfeldt-Jacob disease in humans.

After a long incubation period, deer and elk infected with CWD suffer neurological and behavioral problems such as staggering, shaking, and excessive salivation and urination. Over time, the animals literally waste away, often dying in woods and fields. Originally detected in the 1960s in Colorado and Wyoming, CWD is now present in 14 states and two Canadian provinces.

Prions are an incorrectly folded variation of a protein normally found in mammals, including humans.

"Prions most likely enter soil via excretion or from the carcasses of infected animals," says lead author Christopher Johnson, a UW-Madison doctoral student in the department of animal health and biomedical sciences. "Our results suggest that reducing the number of infected animals -- as has been done in the recent outbreak of CWD in Wisconsin -- could limit the potential for further (disease) spread. These results also suggest that other species that s


Page: 1 2 3

Related biology news :

1. Alzheimers prevention role discovered for prions
2. Brittle prions are more infectious
3. Pall blood filtration technology removes prions that can cause TSEs
4. Deadly infectious entity of prions discovered
5. First technology to remove prions that cause vCJD from blood launched
6. Removing prions that cause mad cow in humans from blood
7. Research confirms that vCJD prions can be removed from blood
8. Study begins to reveal clues to the cause and progression of sepsis
9. Pollution causes 40 percent of deaths worldwide, study finds
10. deCODE discovers cause of major subtype of glaucoma
11. Inflammation may cause preterm labor and fetal deaths

Post Your Comments:

(Date:8/5/2020)... , ... August 05, 2020 , ... Regenative Labs has ... new innovations, CoreText™ and ProText™, making them the first Wharton’s jelly allografts to be ... a syringe. The company’s solutions are the first Wharton’s jelly allograft product to be ...
(Date:7/18/2020)... ... 2020 , ... A study has been published in the ... noise control device to attenuate typical noises in a simulated neonatal intensive care ... sounds from patient monitors, ventilators and other bedside devices that would affect the ...
(Date:7/2/2020)... ... July 01, 2020 , ... AltruBio Inc. http://www.altrubio.com , ... biologic for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), at European Hematology ... Martin of the Fred Hutchinson Cancer Research Center, this single-arm, open-label Phase 1 ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... ... August 12, 2020 , ... Inc. magazine today revealed ... in FDA compliance consulting has been named on its annual Inc. 5000 list, ... a unique look at the most successful companies within the American economy’s most ...
(Date:8/3/2020)... Ky. (PRWEB) , ... August 03, 2020 , ... Introducing ... products for transformative growth, , Known as MediVet Biologics since ... brand. , The new Ardent Animal Health will build on its base ...
(Date:7/31/2020)... ... July 29, 2020 , ... Diversified Technologies, ... that can be configured to drive Klystrons, TWTs, IOTs, and magnetrons. , ... or two switches in a push-pull configuration; yielding fast fall time for a ...
(Date:7/31/2020)... ... July 29, 2020 , ... eSource has long been ... webinar will cover the history of eSource, the reasons it did not take off ... wearables, to site source, the industry is moving towards capturing data electronically for clinical ...
Breaking Biology Technology:
Cached News: