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Solexa and collaborating scientists illuminate the small RNA component of the transcriptome

P>"The signature sequencing approach makes possible the study of global identity, regulation and function of small RNA populations in diverse organisms. This extensive small RNA data will help biologists understand small RNAs and their regulation," said Blake Meyers, an Assistant Professor at the University of Delaware and a senior author on the study. "We have also released an enhanced version of our Arabidopsis MPSS website (http://mpss.udel.edu/at) to further facilitate public access and use of these data."

"These experiments underscore the importance of studying the entire genome for evidence of small RNA activity. The newly discovered small RNAs that match to genes are exciting, but so are those that derive from relatively featureless regions between genes," added Pamela J. Green, a professor at the University of Delaware and the Delaware Biotechnology Institute, another senior author on the study.

About small RNAs
The two major categories of small RNAs are microRNAs (miRNAs) and small interfering RNAs (siRNAs). Small RNAs function to silence genes by inhibiting the synthesis or function of mRNA. Deficiencies in small RNA production can have a profound effect on development, and small RNAs have been associated with other important biological processes such as stress responses. In addition, recent data suggests a possible role for small RNA profiling in cancer diagnostics.

About Solexa
Solexa, Inc. is developing and preparing to commercialize a new genetic analysis instrument system which will be used to perform a range of analyses including whole genome resequencing, gene expression analysis and small RNA analysis. We expect the first generation of Solexa's new technology to generate over a billion bases of DNA sequence per run and to enable whole genome resequencing below $100,000 per sample, making it the first platform to reach this important milestone. Solexa's lo
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Contact: Mark Stuart
mstuart@lhai.com
310-691-7116
Lippert/Heilshorn and Associates
6-Sep-2005


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