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Solexa and collaborating scientists illuminate the small RNA component of the transcriptome

nger-term goal is to reduce the cost of human re-sequencing to a few thousand dollars for use in a wide range of applications from basic research through clinical diagnostics. The Company expects to introduce its first instrument system by the end of 2005. For further information, please visit www.solexa.com.

This press release contains "forward-looking" statements, including statements related to the current views of Solexa management as to future products, product development including the commercial introduction of the Company's novel genetic analysis technology, the expansion and success of Solexa's commercial application of its genomics technologies and the future financial performance of Solexa. Any statements contained in this press release that are not statements of historical fact may be deemed to be forward-looking statements. Words such as "believes," "anticipates," "plans," "predicts," "expects," "envisions," "hopes," "estimates," "intends," "will," "continue," "may," "potential," "should," "confident," "could" and similar expressions are intended to identify forward-looking statements. There can be no assurance that such expectations of any of the forward-looking statements will prove to be correct, and actual results could differ materially from those projected or assumed in the forward-looking statements. There are a number of important factors that could cause the results of Solexa to differ materially from those indicated by these forward-looking statements including, among others, risks detailed from time to time in the Company's SEC reports, including its Annual Report on Form 10-K for the year ended December 31, 2004 and its Form 10-Q for the quarter ended June 30, 2005. Solexa does not undertake any obligation to update forward-looking statements.

CONTACTS:

Solexa, Inc.
Omead Ostadan
Vice President of Marketing
(510) 670-9300

Contact: Mark Stuart
mstuart@lhai.com
310-691-7116
Lippert/Heilshorn and Associates
6-Sep-2005


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