HOME >> BIOLOGY >> NEWS
Source of crucial immune cell in the skin discovered

Mount Sinai School of Medicine researchers have identified the precursors of cells in the skin that are part of the first line of defense against invading pathogens. The study will appear on Nature Immunology's website this week and will be published in a future issue.

A tight network of cells covering the entire body is formed in the skin by a group of cells known as Langerhans cells. These cells ingest antigens present in the skin and transport them to lymph nodes, activating the immune system to protect the body against pathogens.

"Langerhans cells are particularly important to the development of tumor immunotherapy," said Miriam Merad, MD, PhD, Assistant Professor of Gene and Cell Medicine at Mount Sinai and lead author of the study. "Most vaccines being developed for tumors are injected into the skin and rely on these cells to transport the antigen to the lymph nodes to trigger an immune response against the tumor."

Once Langerhans cells transport an antigen, they need to be replaced to maintain the tight network in the skin. Dr. Merad and colleagues at Mount Sinai School of Medicine recently discovered that when skin is inflamed Langerhans cells are replaced by circulating precursor cells. They have now identified what this precursor cell is and identified a protein that is essential to the transformation of these precursor cells into Langerhans cells.

The researchers put fluorescent beads in mice in a group of immune cells known as monocytes. They then followed the cells to observe their fate. They found that a specific type of monocyte know as Gr-1 homes to inflamed skin, proliferates, and then differentiates to form Langerhans cells. They also found that a protein, called colony stimulating factor receptor (Csf-1) is necessary for the transformation of Gr-1 cells into Langerhans cells.

The researchers state that discovery of how Langerhans cells are replaced "should contribute to ongoing efforts to engineer immune re
'"/>

Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
29-Jan-2006


Page: 1 2

Related biology news :

1. Open Source Biotechnology alliance for international agriculture
2. Source of molecular triggers in cutaneous T cell lymphoma identified
3. Brown team finds crucial protein role in deadly prion spread
4. Large size crucial for Amazon forest reserves
5. Jefferson scientists find guardian genes choices crucial to stopping cancer process
6. Tissue geometry plays crucial role in breast cell invasion
7. UGA researchers discover cell-wall carbohydrate that is crucial to anthrax bacterium
8. Preconception care crucial to improving maternal and infant health
9. Defects in crucial brain protein implicated in memory loss
10. Researchers add crucial information on how the bodys T cells react to parasitic diseases
11. Heart has enough oxygen to survive hypothermia, CPR crucial

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/11/2018)... ... October 11, 2018 , ... ... behind the National Institute for Innovation in Manufacturing Biopharmaceuticals (NIIMBL). The Institute, a ... to advance biopharmaceutical manufacturing and workforce development in the United States. Biopharmaceuticals are ...
(Date:10/5/2018)... YORBA LINDA, Calif. (PRWEB) , ... October 04, 2018 , ... ... inaccurate results of some of the tests such as cardiac troponin has serious clinical ... US population, although the exact prevalence is still unknown. , High dose of ...
(Date:10/2/2018)... ... October 02, 2018 , ... Stuart is a fun-loving eight-year-old Labrador retriever. Like ... his owner, Cynthia, “He loves playing ball so much that whenever anyone comes to our ... play a game of fetch.” In early 2017, Stuart began limping and eventually could ...
Breaking Biology News(10 mins):
(Date:9/28/2018)... YORBA LINDA, Calif. (PRWEB) , ... September 28, ... ... educational and interactive virtual events for tech innovators, engineers, and scientists from around ... Peru studying at the National University of San Marcos, as the winner of ...
(Date:9/27/2018)... , ... September 26, 2018 , ... ... are way ahead of their primary care physicians, according to a new Zeldis ... study, patients and doctors were asked about consumer adoption of fitness and health ...
(Date:9/27/2018)... ... 26, 2018 , ... Nvision Biomedical Technologies , a ... today at the North American Spine Society (NASS) Annual Meeting, held at the ... Screw System, which received clearance from the U.S. Food and Drug Administration (FDA) ...
(Date:9/27/2018)... Hungary and CAMBRIDGE, Mass. (PRWEB) , ... September ... ... in Budapest with US offices in Cambridge, MA, announce today that Holotype HLA ... or collaborators at the annual meeting of the American Society for Histocompatibility and ...
Breaking Biology Technology:
Cached News: