Source of molecular triggers in cutaneous T cell lymphoma ...( and treatment of CTCL as well as poten...)

and treatment of CTCL, as well as potentially contributing to the investigation of other types of lymphomas," said Edelson. "It may now be possible to identify specific antigens and target the malignant cells with selective poisons delivered through the vehicle of LC."

The study also showed that CTCL cells, after stimulation by LC, become functioning regulatory T (Treg) cells that suppress the immune responses of normal T cells to microbial agents. This may explain the susceptibility of patients with extensive CTCL to opportunistic infections.

"Through understanding T cell and dendritic cell interactions, we may gain the ability to manage a spectrum of maladies ranging from cancer to disorders of immune regulation," said Edelson. "Inhibiting Treg-cell generation may be useful for cancer immunotherapy and promoting Treg development may be useful to induce tolerance in autoimmune disease and transplantation,"

'"/>

Contact: Janet Rettig Emanuel
janet.emanuel@yale.edu
203-432-2157
Yale University
26-Feb-2005

Page: 1 2
Related biology news :

1. Source of crucial immune cell in the skin discovered
2. Open Source Biotechnology alliance for international agriculture
3. New textbook illuminates the close links between evolutionary and molecular biology
4. New molecular regulators of hyperthyroidism and goiter
5. A novel molecular dictator with a conscience discovered
6. UC Santa Barbara scientists clarify molecular basis of interferon action
7. MU researchers make discovery in molecular mechanics of phototropism
8. Malaria-resistant mosquitoes battle disease with molecular warhead
9. University of Cincinnati receives $1.7M to research molecular treatment of brain injury
10. Casting the molecular net
11. Tumor vessels identified by unique molecular markers