HOME >> BIOLOGY >> NEWS
Sox17 required for steps from embryonic to heart muscle cell

An important choreographer of the complicated dance of signals, enzymes and proteins that takes embryonic stem cells through the steps to becoming a beating heart muscle cell is the gene Sox17, said researchers from Baylor College of Medicine in a report in the current issue of the Proceedings of the National Academy of Sciences.

To be precise, Sox17 is critical in transforming primitive mesoderm (an early layer of tissue in the embryo) into the more specialized cardiac mesoderm from which heart muscle develops, said Dr. Michael Schneider, senior researcher of the report.

"Heart muscle formation by embryonic stem cells is a complex, multi-step process," said Schneider, professor of medicine, molecular and cellular biology, and molecular physiology and biophysics at Baylor College of Medicine. "We have succeeded in uncoupling the formation of cardiac mesoderm from its antecedent steps. That discovery provides immediate insight into how one might seek to generate cardiac muscle more effectively from embryonic stem cells."

"One of the major challenges is the very meager ability of the heart muscle to restore itself after cell death," said Schneider. Heart muscle cells die acutely during heart attacks and sporadically in chronic heart failure.

"Identifying stem cells that can be encouraged along the path to becoming heart muscle is a paramount scientific goal," he said.

Embryonic stem cells are a potential source because they have the potential of becoming every type of cell in the body. However, much research remains before scientists can outline a blueprint for how these totally undifferentiated cells can be guided to the "fate" of becoming heart muscle selectively.

Schneider and his colleagues used proteins that block certain signals for cell specialization at the surface of mouse embryonic stem cells to pinpoint early steps that lead to the development of heart muscle. Then, using "gene chip" technolo
'"/>

Contact: Ross Tomlin
htomlin@bcm.edu
713-798-4710
Baylor College of Medicine
26-Feb-2007


Page: 1 2

Related biology news :

1. Why is long-term therapy required to cure tuberculosis?
2. Sunnybrook researchers identify which sets of molecules are required to induce T cells
3. New study reveals signaling pathways required for expansion of pancreas stem cells
4. Study finds protein is required for human chromosome production
5. Molecular partners required for appropriate neuronal gene repression
6. B cells are required for development of epithelial cancer associated with chronic inflammation
7. Gene variations explain drug dose required to control seizures
8. Novel asthma study shows multiple genetic input required; single-gene solution shot down
9. How cells change the pace of their steps
10. Penn researchers discover initial steps in the development of taste
11. For Stanford scientists, RNAi gene therapy takes two steps forward, one step back

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Sox17 required for steps from embryonic heart muscle cell

(Date:5/8/2015)... SAN JOSE, Calif. , May 8, 2015 ... human interface solutions, today announced that members of the executive ... J.P. Morgan 43rd Annual Technology, Media and Telecom Conference ... Westin Waterfront Hotel in Boston, MA ... Date: May 27, 2015 Time: 2:45pm ET Location: The New ...
(Date:5/6/2015)... May 6, 2015 LifeBEAM, a developer of ... producer, announced today that they will expand their partnership ... first bio-sensing cycling helmet and the first joint project ... new colors in order to give cyclists more style ... addition, LifeBEAM and Lazer announced their plan to release ...
(Date:4/27/2015)... more than four decades, AUVSI,s Unmanned Systems ... event for the unmanned land, sea, and air industries. ... local, national, or trade news organization interested in gathering ... applications of unmanned technologies. The conference will explore the ... and how it will soon impact the lives of ...
Breaking Biology News(10 mins):Synaptics to Present at Upcoming Investor Conferences 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 3UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 3UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 4UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 5
(Date:5/21/2015)... 2015 Patent Offering, The patent’s technology ... or therapeutic imaging within a body lumen (open space). ... having a low cost, single-use disposable illumination and camera ... October 18, 2013 and the patent approval was received ... physician to customize the lighting and magnification of the ...
(Date:5/21/2015)... Ontario (PRWEB) May 21, 2015 ... into an exclusive North American distribution agreement with ... testing system. , With more than 160 years ... products and services for laboratory and production facilities, ... operational excellence and differentiated services to enable science. ...
(Date:5/20/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/qfxkcq/global_cell ) has ... Market Outlook 2020 " report to their offering. ... regenerative medicine is expected to have huge marketing potential. ... in the growth of deregulated organs. Several therapeutic molecules ... to form new tissue or sometimes organ transplant is ...
(Date:5/20/2015)... NEW YORK , May 20, 2015 /PRNewswire-USNewswire/ ... announced a leadership gift of $100 million from ... help create a new laboratory building that will ... campus extension. The Marie-Josée and Henry R. Kravis ... over the FDR Drive, spanning approximately three city ...
Breaking Biology Technology:IpAuctions™ Presents The Worlds Smallest Disposable Illuminated Endoscope For Auction 2IpAuctions™ Presents The Worlds Smallest Disposable Illuminated Endoscope For Auction 3Veolia’s TECTA™ B16 Instrument for E. Coli Detection is Offered Exclusively Through VWR 2Global Cell Therapy Market Outlook 2015-2020 - 262 Cell Therapies & 13 Marketed Cell Therapies 2Global Cell Therapy Market Outlook 2015-2020 - 262 Cell Therapies & 13 Marketed Cell Therapies 3The Marie-Josee and Henry R. Kravis Foundation Provides Landmark Gift of $100 Million to The Rockefeller University 2The Marie-Josee and Henry R. Kravis Foundation Provides Landmark Gift of $100 Million to The Rockefeller University 3The Marie-Josee and Henry R. Kravis Foundation Provides Landmark Gift of $100 Million to The Rockefeller University 4
Cached News: