HOME >> BIOLOGY >> NEWS
Sox17 required for steps from embryonic to heart muscle cell

An important choreographer of the complicated dance of signals, enzymes and proteins that takes embryonic stem cells through the steps to becoming a beating heart muscle cell is the gene Sox17, said researchers from Baylor College of Medicine in a report in the current issue of the Proceedings of the National Academy of Sciences.

To be precise, Sox17 is critical in transforming primitive mesoderm (an early layer of tissue in the embryo) into the more specialized cardiac mesoderm from which heart muscle develops, said Dr. Michael Schneider, senior researcher of the report.

"Heart muscle formation by embryonic stem cells is a complex, multi-step process," said Schneider, professor of medicine, molecular and cellular biology, and molecular physiology and biophysics at Baylor College of Medicine. "We have succeeded in uncoupling the formation of cardiac mesoderm from its antecedent steps. That discovery provides immediate insight into how one might seek to generate cardiac muscle more effectively from embryonic stem cells."

"One of the major challenges is the very meager ability of the heart muscle to restore itself after cell death," said Schneider. Heart muscle cells die acutely during heart attacks and sporadically in chronic heart failure.

"Identifying stem cells that can be encouraged along the path to becoming heart muscle is a paramount scientific goal," he said.

Embryonic stem cells are a potential source because they have the potential of becoming every type of cell in the body. However, much research remains before scientists can outline a blueprint for how these totally undifferentiated cells can be guided to the "fate" of becoming heart muscle selectively.

Schneider and his colleagues used proteins that block certain signals for cell specialization at the surface of mouse embryonic stem cells to pinpoint early steps that lead to the development of heart muscle. Then, using "gene chip" technolo
'"/>

Contact: Ross Tomlin
htomlin@bcm.edu
713-798-4710
Baylor College of Medicine
26-Feb-2007


Page: 1 2

Related biology news :

1. Why is long-term therapy required to cure tuberculosis?
2. Sunnybrook researchers identify which sets of molecules are required to induce T cells
3. New study reveals signaling pathways required for expansion of pancreas stem cells
4. Study finds protein is required for human chromosome production
5. Molecular partners required for appropriate neuronal gene repression
6. B cells are required for development of epithelial cancer associated with chronic inflammation
7. Gene variations explain drug dose required to control seizures
8. Novel asthma study shows multiple genetic input required; single-gene solution shot down
9. How cells change the pace of their steps
10. Penn researchers discover initial steps in the development of taste
11. For Stanford scientists, RNAi gene therapy takes two steps forward, one step back

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/19/2016)... , UAE, April 20, 2016 ... implemented as a compact web-based "all-in-one" system solution for ... biometric fingerprint reader or the door interface with integration ... modern access control systems. The minimal dimensions of the ... readers into the building installations offer considerable freedom of ...
(Date:3/31/2016)... , March 31, 2016 ... ) ("LegacyXChange" or the "Company") LegacyXChange is ... users of its soon to be launched online site ... https://www.youtube.com/channel/UCyTLBzmZogV1y2D6bDkBX5g ) will also provide potential shareholders ... of DNA technology to an industry that is notorious ...
(Date:3/22/2016)... PROVO and SANDY, Utah ... Ontario (NSO), which operates the highest sample volume laboratory ... and Tute Genomics and UNIConnect, leaders in clinical sequencing ... announced the launch of a project to establish the ... panel. NSO has been contracted by ...
Breaking Biology News(10 mins):
(Date:5/27/2016)... ISELIN, New Jersey and ... 2016 Indegene ( ... kommerziellen und marketingorientierten Lösungen für die Life-Science-Branche, ... ), ein bekannter weltweiter Anbieter von innovativen ... im Zuge des Starts von IntraScience heute ...
(Date:5/26/2016)... Jersey and READING, England ... Indegene ( http://www.indegene.com ), a leading global ... life science, pharmaceutical and healthcare organisations and TranScrip ... innovative scientific support throughout the product lifecycle, today ... the launch of IntraScience.      (Logo: ...
(Date:5/26/2016)... ... May 26, 2016 , ... After several ... Inc. at the City of Knowledge in Panama, a 6 year-old Duchenne’s ... the US earlier this year following FDA approval of a second application for ...
(Date:5/25/2016)... ... , ... Lajollacooks4u has become a rising hotspot for specialized team building events ... attractions. Fortune 500 companies, such as Illumina, Hewlett-Packard, Qualcomm and Elsevier, have traveled ... , Each event kicks off with an olive oil and salt-tasting competition. From ...
Breaking Biology Technology:
Cached News: