HOME >> BIOLOGY >> NEWS
Soy diet worsens heart disease in mice, says University of Colorado at Boulder study

A University of Colorado at Boulder study has shown the health of mice carrying a genetic mutation for a disease that is the leading cause of sudden cardiac death in people under 30 worsened considerably when the animals were fed a soy-based diet.

Male mice carrying the mutation for hypertrophic cardiomyopathy, or HCM, were severely affected by the soy diet, exhibiting progressively enlarged heart muscles and eventual heart failure, said CU-Boulder Professor Leslie Leinwand. When the mice in the study were switched to a diet of the milk protein, casein, the condition of the males improved markedly, said Leinwand, chief author of the study.

Female mice carrying the mutation for HCM, which is characterized by the thickening of heart muscle that can obstruct blood flow, were relatively unaffected, she said. The research team hypothesized that heart deterioration in male mice was due at least in part to plant-based estrogens in the soy food diet that triggered a cascade of biochemical reactions and ultimately increased apoptosis, or programmed cell death, in the heart.

"We were shocked by the results," said Leinwand, chair of the molecular, cellular and developmental biology department and chief study author. "This study shows that at least in mice, diet can have a more profound effect on heart disease than any drug that we could imagine."

A paper on the subject by Leinwand, Dr. Brian Stauffer, a cardiologist at Denver Health Medical Center and the University of Colorado Health Sciences Center, CU-Boulder research associate John Konhilas and doctoral student Elizabeth Luczak appears in the January issue of the Journal of Clinical Investigation, one of the nation's leading medical journals.

"To our knowledge this is the first report of significant differences in cardiac muscle adaptation due to dietary manipulation," the researchers wrote in JCI.

The CU research team speculated the soy diet affected male mice mo
'"/>

Contact: Leslie Leinwand
leslie.leinwand@colorado.edu
303-492-7606
University of Colorado at Boulder
4-Jan-2006


Page: 1 2 3

Related biology news :

1. Loud music worsens effects of taking ecstasy
2. Study: Inadequate physical activity worsens as teenagers become adults
3. High blood pressure, low energy -- a recipe for heart failure
4. Abnormal fat metabolism underlies heart problems in diabetic patients
5. Cardio exercise benefits in male vs. female hearts
6. Using stem cells to help heart attack victims
7. System to analyze beating heart stem cells could lead to heart attack treatments
8. Cardiac patches stimulate regeneration, improve function after heart attack
9. Specific type of cell death may accelerate decompensated heart failure
10. Faulty cell membrane repair causes heart disease
11. Link between obesity and enlarged heart discovered by University of Arizona researchers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/29/2017)... 2017  higi, the health IT company that operates ... America , today announced a Series B investment ... EveryMove. The new investment and acquisition accelerates higi,s strategy ... transform population health activities through the collection and workflow ... higi collects and secures data today on behalf of ...
(Date:3/24/2017)... Research and Markets has announced the addition of the "Global ... to 2025" report to their offering. ... The Global Biometric Vehicle Access System Market ... the next decade to reach approximately $1,580 million by 2025. ... for all the given segments on global as well as regional ...
(Date:3/22/2017)... , March 21, 2017 ... Cloud used by retailers such as 1-800-Flowers and ... platform — Product Recommendations and Replenishment. Using Optimove,s machine ... more personalized product and replenishment recommendations to their ... also on predictions of customer intent drawn from ...
Breaking Biology News(10 mins):
(Date:7/13/2017)... ... July 13, 2017 , ... Heritage Biologics is proud ... the independent leader in promoting healthcare quality through accreditation, certification and measurement. By ... improved processes and better patient outcomes. , “Achieving URAC accreditation is a ...
(Date:7/13/2017)... , ... July 13, 2017 , ... ... two spectrophotometer calibration standards. Blast forward seven years and now they are ... holmium oxide for wavelength accuracy, and resolution testing. , ...
(Date:7/13/2017)... Philadelphia, PA (PRWEB) , ... July 13, 2017 ... ... and business acceleration programs at Philadelphia’s University City Science Center, Christopher Laing, MRCVS, ... innovation zone in Austin, Texas. Dr. Laing will become the first Executive ...
(Date:7/13/2017)... ... ... Microscan , the number-one brand of embedded clinical barcode readers and leading ... platform for barcode reading and machine vision, LVS label verification, and print ... place on August 1–3 in San Diego, CA. , MicroHAWK barcode readers ...
Breaking Biology Technology:
Cached News: