HOME >> BIOLOGY >> NEWS
Specialized immune-system B cells play double-barreled role

DURHAM, N.C. -- A specialized subpopulation of the antibody-producing B cells of the immune system plays a "double-barreled" role in triggering both kinds of immunity -- innate and acquired, Duke University Medical Center immunologists have discovered. The division of labor between B-1a and B-1b cells they have uncovered offers basic insights that could contribute to more rational development of vaccines, they said.

B cells are the arms factories of the immune system, producing antibodies that target invading microbes for destruction. Generally, B-1 cells have been thought to play a major role in the innate immune response -- the type of immunity that offers rapid, generalized responses to infections. Less understood has been any role in adaptive immunity -- in which the immune system develops a long-term immune response to an invader after vaccination or infection.

The researchers -- Karen Haas, Jonathan Poe, Douglas Steeber and Thomas Tedder -- published their findings in the July 2005 issue of the journal Immunity. The research was sponsored by the National Institutes of Health, the Arthritis Foundation, the Lymphoma Research Foundation and the Leukemia & Lymphoma Society.

The researchers studied a particular type of B cell called the B-1 cell. In contrast to the more conventional B-2 cells, B-1 cells have different distinguishing characteristics such as behavior, anatomical localization and types of antibodies produced. In contrast to well-studied B-2 cells, the cellular origins of B-1 cells and their subtypes remain unknown.

"The true function of B-1 cells in the body has been highly controversial over the past two decades," said Tedder. "They appear to be a primary defense mechanism for innate immunity in infections. In particular, however, the B-1b cells have been largely ignored because they're present in relatively small numbers and are difficult to work with."

In the studies, Haas and her colleagues used two genetica
'"/>

Contact: Dennis Meredith
dennis.meredith@duke.edu
919-681-8054
Duke University Medical Center
26-Jul-2005


Page: 1 2 3

Related biology news :

1. Specialized, bone-crushing wolves of Alaska disappeared long ago
2. New study may show how to forestall a fatal, virus-caused immune-system meltdown
3. Researchers in Montral and the US create model of key immune-system component
4. Fox Chase Cancer Center scientists identify immune-system mutation
5. IRCM scientist demonstrates basic active mechanism of immune-system cells
6. Newly created cancer stem cells could aid breast cancer research
7. ESF EURYI award winner aims to stop cancer cells reading their own DNA
8. OHSU turns mouse into factory for human liver cells
9. UCLA scientists produce functioning neurons from human embryonic stem cells
10. UCF research links proteins, stem cells and potential Alzheimers treatment
11. Teamwork between 2 key proteins necessary for normal development and regulation of red blood cells

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/13/2016)... April 13, 2016  IMPOWER physicians supporting Medicaid patients ... a new clinical standard in telehealth thanks to a ... the higi platform, IMPOWER patients can routinely track key ... body mass index, and, when they opt in, share ... visit to a local retail location at no cost. ...
(Date:3/29/2016)... Florida , March 29, 2016 ... the "Company") LegacyXChange "LEGX" and SelectaDNA/CSI Protect are pleased ... in ink used in a variety of writing instruments, ... Buyers of originally created collectibles from athletes on LegacyXChange ... forensic analysis of the DNA. Bill ...
(Date:3/22/2016)... Ontario , PROVO and ... Newborn Screening Ontario (NSO), which operates the ... for molecular testing, and Tute Genomics and UNIConnect, ... management technology respectively, today announced the launch of a ... next-generation sequencing (NGS) testing panel. NSO ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... 2016 , ... Mosio, a leader in clinical research patient ... and Retention Tips.” Partnering with experienced clinical research professionals, Mosio revisits the hurdle ... and strategies for clinical researchers. , “The landscape of how patients receive and ...
(Date:6/23/2016)... 2016   Boston Biomedical , an industry ... to target cancer stemness pathways, announced that its ... Drug Designation from the U.S. Food and Drug ... including gastroesophageal junction (GEJ) cancer. Napabucasin is an ... cancer stemness pathways by targeting STAT3, and is ...
(Date:6/23/2016)... , June 23, 2016 A person commits ... the crime scene to track the criminal down. ... U.S. Food and Drug Administration (FDA) uses DNA evidence to ... Sound far-fetched? It,s not. The FDA has ... to support investigations of foodborne illnesses. Put as simply as ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... (Yeast and Mold) microbial test has received AOAC Research Institute approval 061601. , ... tests introduced last year,” stated Bob Salter, Vice President of Regulatory and Industrial ...
Breaking Biology Technology:
Cached News: