HOME >> BIOLOGY >> NEWS
Sperm created in the laboratory from embryonic stem cells produce viable progeny

Scientists have demonstrated for the first time that embryonic stem (ES) cells cultured in the laboratory can produce sperm with the capacity to produce viable offspring. The research, published in the July issue of Developmental Cell, opens many exciting avenues for future studies, including investigation of mechanisms involved in sperm production and development of new treatment strategies for infertility.

Previous studies have shown that ES cells grown in the laboratory can differentiate into primordial germ cells that then give rise to cells resembling mature egg and sperm cells, known as gametes. However, the functionality of the gametes has not been thoroughly tested and many questions about the viability of these cells remain unanswered. Dr. Karim Nayernia and Dr. Wolfgang Engel from the Institute of Human Genetics at the University of Goettingen in Goettingen, Germany and colleagues developed a new strategy for generating mature sperm cells in the laboratory using ES cells from mice and went on to test the functionality of the ES-derived sperm.

ES cells were treated with specific factors know to direct sperm production and screened for characteristics associated with primordial and spermatagonial stem cells. The researchers demonstrated that these cells could be further differentiated into mature sperm in the laboratory or could be transplanted into the testes of mice where they retained the capacity develop into sperm. Intra-cytoplasmic injection of the ES-derived sperm into mouse eggs resulted in successful fertilization and the resulting early stage embryos were successfully transplanted into mice. Six of the seven mice born developed into adult mice.

The results of this study establish that the ES cell derived cell lines can produce functional sperm in the laboratory which can be used to successfully fertilize eggs and support full-term development into embryos and adult mice. "Our approach provides an accessible in vitro
'"/>

Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
11-Jul-2006


Page: 1 2

Related biology news :

1. Sperm proteome gives tantalizing glimpse towards the origin of sex
2. Sperm stem cells closer to being like embryonic stem cells
3. Sperm trading can resolve hermaphrodite mating conflicts
4. Sperm enzyme is essential for male fertility, study shows
5. Newly created cancer stem cells could aid breast cancer research
6. Not all embryonic stem cell lines are created equal
7. Early-stage sperm cells created from human bone marrow
8. Researcher examines polymers created with poultry feathers
9. First direct electric link between neurons and light-sensitive nanoparticle films created
10. All itches not created equal -- Different parts of brain activated depending on cause
11. Cloned mice created from fully differentiated cells, a milestone in cloning research

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/9/2016)... Inc. (NASDAQ: AWRE ), a leading supplier of biometrics software ... year ended December 31, 2015.  --> ... $6.9 million, an increase of 61% compared to $4.3 million in ... of 2015 was $2.6 million compared to $0.2 million in the ... --> Higher revenue and operating income in the fourth quarter ...
(Date:2/8/2016)... 2016 Worldcore is ... innovation for clients, comfort and unbeatable security, with ... --> Worldcore is the first EU-regulated ... comfort and unbeatable security, with a Voice Biometrics ... Worldcore is the first EU-regulated global payment ...
(Date:2/4/2016)... , Feb. 4, 2016 The ... apparently one of the most popular hubs of ... MetaHIT and other huge studies of human microbiota, ... past few years, the microbiome space has literally ... biomedical research. This report focuses on biomedical ...
Breaking Biology News(10 mins):
(Date:2/10/2016)... ... February 10, 2016 , ... ... that it has joined the Human Vaccines Project, a public-private partnership to ... cancer. , The Human Vaccines Project brings together leading pharmaceutical and ...
(Date:2/10/2016)... 10, 2016  Matchbook, Inc., a company specializing ... biotech companies, announced today the appointment of ... Jim brings nearly 25 years of experience in ... spent nearly two decades in executive level roles ... at Genzyme and, most recently headed global logistics ...
(Date:2/10/2016)... NY (PRWEB) , ... February 10, 2016 , ... LATHAM, ... packages at the SPIE Photonics West conference in San Francisco’s Moscone Center ... 14 in the same venue. , These latest InGaAs PIN diode standard packages ...
(Date:2/10/2016)... MA (PRWEB) , ... February 10, 2016 , ... ... is now available on Microsoft Azure. On Azure, Arvados provides capabilities for managing ... saw clear demand for Microsoft Azure from major institutions collecting and analyzing genomic ...
Breaking Biology Technology:
Cached News: