HOME >> BIOLOGY >> NEWS
Sperm created in the laboratory from embryonic stem cells produce viable progeny

Scientists have demonstrated for the first time that embryonic stem (ES) cells cultured in the laboratory can produce sperm with the capacity to produce viable offspring. The research, published in the July issue of Developmental Cell, opens many exciting avenues for future studies, including investigation of mechanisms involved in sperm production and development of new treatment strategies for infertility.

Previous studies have shown that ES cells grown in the laboratory can differentiate into primordial germ cells that then give rise to cells resembling mature egg and sperm cells, known as gametes. However, the functionality of the gametes has not been thoroughly tested and many questions about the viability of these cells remain unanswered. Dr. Karim Nayernia and Dr. Wolfgang Engel from the Institute of Human Genetics at the University of Goettingen in Goettingen, Germany and colleagues developed a new strategy for generating mature sperm cells in the laboratory using ES cells from mice and went on to test the functionality of the ES-derived sperm.

ES cells were treated with specific factors know to direct sperm production and screened for characteristics associated with primordial and spermatagonial stem cells. The researchers demonstrated that these cells could be further differentiated into mature sperm in the laboratory or could be transplanted into the testes of mice where they retained the capacity develop into sperm. Intra-cytoplasmic injection of the ES-derived sperm into mouse eggs resulted in successful fertilization and the resulting early stage embryos were successfully transplanted into mice. Six of the seven mice born developed into adult mice.

The results of this study establish that the ES cell derived cell lines can produce functional sperm in the laboratory which can be used to successfully fertilize eggs and support full-term development into embryos and adult mice. "Our approach provides an accessible in vitro
'"/>

Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
11-Jul-2006


Page: 1 2

Related biology news :

1. Sperm proteome gives tantalizing glimpse towards the origin of sex
2. Sperm stem cells closer to being like embryonic stem cells
3. Sperm trading can resolve hermaphrodite mating conflicts
4. Sperm enzyme is essential for male fertility, study shows
5. Newly created cancer stem cells could aid breast cancer research
6. Not all embryonic stem cell lines are created equal
7. Early-stage sperm cells created from human bone marrow
8. Researcher examines polymers created with poultry feathers
9. First direct electric link between neurons and light-sensitive nanoparticle films created
10. All itches not created equal -- Different parts of brain activated depending on cause
11. Cloned mice created from fully differentiated cells, a milestone in cloning research

Post Your Comments:
(Date:7/29/2014)... wildfires that have been plaguing the Northern Territories in ... Great Lakes in the U.S. continue on. NASA,s ... Resolution Imaging Spectroradiometer, MODIS, instrument on July 26, 2014. ... outlined in red. Copious amount of smoke are drifting ... havoc for residents of Yellowknife. Fire has caused ...
(Date:7/29/2014)... -- When it comes to technology, healthcare is usually one of the ... when it comes to wearables, healthcare is trying to move ahead ... of Things and its wearable cousins is less than mature, these ... whether it,s in the hospital for a major procedure or for ... that in mind, InformationWeek editor Rodney Brown set ...
(Date:7/29/2014)... Aarhus University researchers have developed an easier method ... strengthen the work involved in diagnosing diseases. , ... provides a strong partnership that can be used ... conjugates which tag proteins with DNA ... sensitive detection and visualisation of biological material. The ...
Breaking Biology News(10 mins):New method provides researchers with efficient tool for tagging proteins 2
(Date:7/29/2014)... PORTLAND, Oregon , July 29, 2014 ... titled, "Global surgical equipment market (types, applications and geography) ... Analysis, Research, Report, Opportunities, Segmentation and Forecast, 2013 - ... expected to reach $12.1 billion by 2020 registering a ... Due to the breakthrough achieved by the electro surgical ...
(Date:7/29/2014)... Colo. , July 29, 2014  Cannabis ... in cannabis formulation-based drug development and related consulting, ... Times for taking a strong position in opposition ... Sunday, July 27, 2014 publication.  The New York ... and articles this week exploring the issue called ...
(Date:7/29/2014)... HILLS, Calif. , July 29, 2014 /PRNewswire/ ... specializing in personalized medicine, treatment of infectious diseases ... strategies of prognosis and prevention of pathologies like ... of August 1, 2014, ImmunoClin Corporation will complete ... Washington, D.C. , a key ...
(Date:7/29/2014)... TransVac Solutions, the trusted leader in ... solutions for hospitals, will be exhibiting at booth #209 ... Conference & Technical Exhibition Aug. 3-6 in Chicago, Ill. ... making hospitals cleaner, reducing infection risk and saving millions ... cycle. Staff will be available at booth #209 ...
Breaking Biology Technology:Global Surgical Equipment Market is expected to reach $12.1 billion by 2020 - Allied Market Research 2Global Surgical Equipment Market is expected to reach $12.1 billion by 2020 - Allied Market Research 3Cannabis Science, Inc. (CBIS) Applauds New York Times Editorial Board Stance on 'Repealing Prohibition, Again'; NYT Editorial Is Bell Weather of Change 2Cannabis Science, Inc. (CBIS) Applauds New York Times Editorial Board Stance on 'Repealing Prohibition, Again'; NYT Editorial Is Bell Weather of Change 3ImmunoClin Corporation (IMCL) Relocates Corporate Headquarters to Washington, DC 2ImmunoClin Corporation (IMCL) Relocates Corporate Headquarters to Washington, DC 3TransVac Presents Cost Saving Technology at ASHE Conference for Keeping Hospitals Cleaner 2
Cached News: