HOME >> BIOLOGY >> NEWS
Sperm created in the laboratory from embryonic stem cells produce viable progeny

Scientists have demonstrated for the first time that embryonic stem (ES) cells cultured in the laboratory can produce sperm with the capacity to produce viable offspring. The research, published in the July issue of Developmental Cell, opens many exciting avenues for future studies, including investigation of mechanisms involved in sperm production and development of new treatment strategies for infertility.

Previous studies have shown that ES cells grown in the laboratory can differentiate into primordial germ cells that then give rise to cells resembling mature egg and sperm cells, known as gametes. However, the functionality of the gametes has not been thoroughly tested and many questions about the viability of these cells remain unanswered. Dr. Karim Nayernia and Dr. Wolfgang Engel from the Institute of Human Genetics at the University of Goettingen in Goettingen, Germany and colleagues developed a new strategy for generating mature sperm cells in the laboratory using ES cells from mice and went on to test the functionality of the ES-derived sperm.

ES cells were treated with specific factors know to direct sperm production and screened for characteristics associated with primordial and spermatagonial stem cells. The researchers demonstrated that these cells could be further differentiated into mature sperm in the laboratory or could be transplanted into the testes of mice where they retained the capacity develop into sperm. Intra-cytoplasmic injection of the ES-derived sperm into mouse eggs resulted in successful fertilization and the resulting early stage embryos were successfully transplanted into mice. Six of the seven mice born developed into adult mice.

The results of this study establish that the ES cell derived cell lines can produce functional sperm in the laboratory which can be used to successfully fertilize eggs and support full-term development into embryos and adult mice. "Our approach provides an accessible in vitro
'"/>

Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
11-Jul-2006


Page: 1 2

Related biology news :

1. Sperm proteome gives tantalizing glimpse towards the origin of sex
2. Sperm stem cells closer to being like embryonic stem cells
3. Sperm trading can resolve hermaphrodite mating conflicts
4. Sperm enzyme is essential for male fertility, study shows
5. Newly created cancer stem cells could aid breast cancer research
6. Not all embryonic stem cell lines are created equal
7. Early-stage sperm cells created from human bone marrow
8. Researcher examines polymers created with poultry feathers
9. First direct electric link between neurons and light-sensitive nanoparticle films created
10. All itches not created equal -- Different parts of brain activated depending on cause
11. Cloned mice created from fully differentiated cells, a milestone in cloning research

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/28/2017)... News solutions for biometrics, bag drop and New ADA-compliant ... At PTE ... March, Materna will present its complete end-to-end passenger journey, ... real benefit for passengers. To accelerate the whole passenger handling ... solutions to take passengers through the complete integrated process with ...
(Date:2/22/2017)... -- With the biometrics market to exceed $10 ... that innovative and agile startups must incorporate into ... changing competitive landscape: multifactor authentication (MFA), point-of-sale (PoS), ... "Companies can no longer afford to cut corners ... Pavlakis , Industry Analyst at ABI Research. "Pairing ...
(Date:2/13/2017)... 2017  RSA Conference -- RSA, a Dell Technologies ... to enhance fraud detection and investigation across digital ... Fraud & Risk Intelligence Suite. The new platform ... insights from internal and external sources as well ... customers from targeted cybercrime attacks. "Fraudsters ...
Breaking Biology News(10 mins):
(Date:3/24/2017)... , Mar. 24, 2017 Research and ... Cell (hESC) Research - Global Strategic Business Report" report to ... ... (hESC) Research in US$ Million. Annual estimates and forecasts are provided ... derived from primary and secondary research. The report ...
(Date:3/24/2017)... , March 24, 2017 On ... trading session at 5,817.69, down 0.07%; the Dow Jones ... and the S&P 500 closed at 2,345.96, marginally dropping ... sectors closed in green, 4 sectors finished in red, ... Friday, Stock-Callers.com has initiated reports coverage on the following ...
(Date:3/24/2017)... LEXINGTON, Mass. , March 24, 2017 ... pipeline of immune checkpoint antibodies and cancer vaccines, today ... The 7 th  Annual William Blair and Maidstone ... Event Space Alexandria Center in New York, ... March 29 at 9:40 am: ...
(Date:3/23/2017)... San Diego, Calif. (PRWEB) , ... March 23, 2017 , ... Lajollacooks4u is proud to ... in 2008, it has hosted corporate cooking challenges for companies around the world, such as ... , Part of the reason for its increasing popularity is due to its new ...
Breaking Biology Technology:
Cached News: