Sperm proteome gives 'tantalizing glimpse' towards the origin of sex

The first ever catalogue of the different types of proteins found in sperm could help reveal the origins of sex and explain some of the mysteries of infertility, say scientists.

Research published in Nature Genetics today describes 381 proteins present in sperm of the fruit fly, Drosophila melanogaster. Whilst more proteins may be identified as research progresses, this study marks the first substantial 'whole-cell' characterisation of the protein components of a higher eukaryotic cell (a cell in which all the genetic components are contained within a nucleus).

This so-called 'proteome' contains everything the sperm needs to survive and function correctly, and scientists can use it to investigate the factors that make some sperm more successful than others.

Around half of the genes of the fruit fly sperm proteome have comparable versions in humans and mice, making it a useful model for studying male infertility in mammals.

By comparing the sperm proteome of the fruit fly with other species, scientists will also be able to rewind evolution and work out the core sperm proteome the most basic constituents a sperm needs for sexual reproduction. This will shed light on how sex itself evolved.

"This is the first catalogue of sperm proteins for any organism, and it offers a tantalising glimpse into how we might begin to answer some of biology's most fundamental questions," said Dr Tim Karr from the University of Bath who led the study.

"Amazingly we know very little about what is in a sperm, which probably explains why we don't really understand sex, let alone how it evolved.

"Before we catalogued the sperm proteome, we only knew a few specific proteins in the Drosophila sperm.

"Being able to compare the structure and content of the proteomes of sperm from different species should help us understand the evolution and origin of sperm.

"We now know of at least 381, which is a grea

Contact: Andrew McLaughlin
University of Bath

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