HOME >> BIOLOGY >> NEWS
Sperm stem cells closer to being like embryonic stem cells

DALLAS Nov. 15, 2005 New experiments that prevented rat sperm stem cells from changing permanently into sperm have brought researchers one step closer to coaxing such cells to behave like embryonic stem cells, capable of growing into many other types of cells in the body.

Researchers at the Cecil H. and Ida Green Center for Reproductive Biology Sciences at UT Southwestern Medical Center devised methods to keep male rat germ-line stem cells sperm precursor cells from differentiating, or changing, into sperm proper. The researchers also froze the sperm stem cells, thawed them, and transplanted them back into rat testes, where they developed into normal sperm.

Dr. David Garbers, professor of pharmacology, director of the Green Center and senior author of a study appearing in an upcoming issue of the Proceedings of the National Academy of Sciences, said the new work has many potential applications, including a possible alternative to embryonic stem cells, the development of new male contraceptives and new animal models to test stem cell-based therapies. Germ-line cells are those such as egg and sperm and their precursors whose genetic material can be passed to offspring.

"The ability to manipulate male germ-line stem cells and get them to grow and self-renew is a major step," said Dr. Garbers, a Howard Hughes Medical Institute investigator at UT Southwestern.

"We're only one step removed from another major step, the Holy Grail for us certainly, which is pushing these cells back a level to a state that is pluripotent-like, similar to embryonic stem cells. That's what we're focused on now."

Pluripotent cells have the potential to change into many other types of cells in the body, such as liver cells and brain cells. Their potential use in humans to treat diseases like diabetes and Parkinson's is controversial because currently the only source of such cells for research is human embryos or mouse cells. Recently another research team published
'"/>

Contact: Amanda Siegfried
amanda.siegfried@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
15-Nov-2005


Page: 1 2 3

Related biology news :

1. Sperm proteome gives tantalizing glimpse towards the origin of sex
2. Sperm created in the laboratory from embryonic stem cells produce viable progeny
3. Sperm trading can resolve hermaphrodite mating conflicts
4. Sperm enzyme is essential for male fertility, study shows
5. Newly created cancer stem cells could aid breast cancer research
6. ESF EURYI award winner aims to stop cancer cells reading their own DNA
7. OHSU turns mouse into factory for human liver cells
8. UCLA scientists produce functioning neurons from human embryonic stem cells
9. UCF research links proteins, stem cells and potential Alzheimers treatment
10. Teamwork between 2 key proteins necessary for normal development and regulation of red blood cells
11. In a first, Einstein scientists discover the dynamics of transcription in living mammalian cells

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/11/2020)... SANTA CLARA, Calif. (PRWEB) , ... March 11, ... ... in IoT solutions for wireless sensing, today announced smart human body temperature infrared ... big data based self-calibrated thermal meter WxS x800-IRTM, supporting flexible wireless uplink for ...
(Date:3/5/2020)... , ... March 05, 2020 , ... Patients in need ... dental implants from Dr. Nickelice Brand of Dental Implants of Ocala. Same-day dental ... get an entirely new smile in just one day. This treatment utilizes advanced technology ...
(Date:3/4/2020)... , ... March 04, 2020 , ... ... products and services, announced it has been nominated as a finalist in the ... Awards. This nomination comes as VGXI expedites manufacturing of a DNA vaccine against ...
Breaking Biology News(10 mins):
(Date:3/10/2020)... (PRWEB) , ... March 10, 2020 , ... Ortho Clinical ... through innovative laboratory solutions, announced its ORTHOTM Sera, ID-MTS, a suite of extended antigen ... transfusion, is cleared to run on ORTHO VISION® and ORTHO VISION® Max in the ...
(Date:3/3/2020)... ... March 03, 2020 , ... ... pharmaceutical, biotech and medical device industries, was recognized by INC. 5,000 on an ... annual lists to note industry leaders greatly impacting their spheres of influence and ...
(Date:2/21/2020)... (PRWEB) , ... February 20, 2020 , ... In a ... join guest speakers from Synteract including Lisa Dilworth, BS, MS, Vice President ... about these challenges, with feasible strategies and solutions to support patients, sites and sponsors. ...
(Date:2/19/2020)... Conn. (PRWEB) , ... February 18, 2020 , ... ... develops tools for characterizing microbiome populations down to the strain level, recently unveiled ... easy-to-use kit designed for efficient and unbiased isolation of high molecular weight (HMW) ...
Breaking Biology Technology:
Cached News: