A British drug discovery company which has developed the world's fastest drug profiling system has joined forces with a Brazilian company to seek new medicines from the South American rain forests.
At a time when the number of new drugs in the world's development pipeline has dwindled, the British company e-Therapeutics has formed a partnership with Brazilian company Grupo TCI to establish a joint research facility close to the Amazonian and Atlantic rain forests, to start testing substances from the millions of plants in the most diverse ecosystem on the planet.
New medicines are needed to combat a range of diseases which threaten to reach pandemic levels, including drug-resistant strains of tuberculosis and virus infections like avian flu. New drugs are also being sought for tropical diseases which occur in Brazil, such as hepatitis C, Chagas disease and Leishmaniasis.
In a separate deal, e-Therapeutics is joining forces with CURA, a pharmaceutical consortium backed by the Brazilian Government, which is establishing a cluster of drug discovery, development and marketing industries in North East Brazil. This will give e-Therapeutics a base from which to access to Brazilian pharmaceutical companies.
e-Therapeutics was spun out of Newcastle University in 2003 by Professor Malcolm Young, who developed new 'systems biology' techniques which can accurately predict the biological effect of any substance on any human tissue and on pathogens, such as bacteria and viruses. He attracted more than 10m research funding from the Engineering and Physical Sciences Research Council and other organisations to turn his ideas into practice.
Professor Young demonstrated the effectiveness of its technology by correctly predicting the effects of known drugs, such as 103 known antibiotics. But it also uncovered unknown antibiotics, which are now entering drug development.