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Statin treatment improves spatial memory in mouse models of Alzheimer's

like disease as they age. In fact, they lose their memory by nine months of age. These animals, together with regular mice without the beta amyloid genes, were acclimated for one week, with as much food and water as they wished, then divided into four groups. Half the Alzheimers mice and half the normal mice received 10 mg/kg Simvastatin for seven days, while half of each group only received saline. Each day the mice had two swimming trials in the water maze, giving them a chance to learn how to reach a platform. Food was always available and safety makes taken during the entire trial.

On the seventh day the animals were tested for spatial memory, in other words low long it took them to find the platform. The Alzheimers mice that received statin were able to find the platform while none of the transgenic mice receiving only saline were able to do so. Normal mice on statin also showed improvement in the time they usually take to reach the platform compared to normal mice on saline. After the maze test, brain tissue then was studied to determine levels of nNOS.


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Contact: Sylvia Wrobel
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Federation of American Societies for Experimental Biology
30-Apr-2007


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