HOME >> BIOLOGY >> NEWS
Stem cells bring fast direct improvement, without differentiation, in acute renal failure

Score one for 'adult' stem cells: First real progress in acute renal failure therapy shows fast, broad results

Paracrine cell signaling, not differentiation, appears to be how stem cells work in initial phase of organ protection, repair

BETHESDA, Md. (August 16, 2005) Acute renal failure, or ARF, is as serious as it sounds. An estimated 40% of critical care hospital admissions experience ARF. Estimates of their death rate range from 50% to 80%, complicated by the fact that patients with ARF often simultaneously suffer failure of other major organ systems.

The most serious form of ARF is caused by ischemia, or loss of blood supply to the kidneys caused by shock, blood infection or major cardiovascular surgery, particularly in such high- risk patients as those with diabetes, underlying renal disease, and the elderly. In the kidneys, such "insults" lead to destruction of kidney tubular and vascular cells, initiating a significant inflammatory response. Recovery of kidney function that is adequate for patient survival depends primarily on the protection and regeneration of destroyed and injured cells.

Yet virtually no progress has been made toward development of any highly effective ARF therapy for decades. "Basically, catastrophic loss of kidney function has remained treatment-resistant despite dialysis and intensive care. Treating patients with ARF thus presents a major clinical dilemma, particularly when severe ARF occurs with multiple organ failure," Christof Westenfelder from the University of Utah explained. "Our laboratory has therefore been pursuing development of novel therapeutic interventions that are urgently needed to treat this common, devastating and costly human disease," Westenfelder said.

Challenging the accepted theory of stem cell operation

In a new study, Westenfelder's team reported that injecting stem cells similar to the type used in bone marrow transplants is
'"/>


15-Aug-2005


Page: 1 2 3 4 5

Related biology news :

1. Newly created cancer stem cells could aid breast cancer research
2. ESF EURYI award winner aims to stop cancer cells reading their own DNA
3. OHSU turns mouse into factory for human liver cells
4. UCLA scientists produce functioning neurons from human embryonic stem cells
5. UCF research links proteins, stem cells and potential Alzheimers treatment
6. Teamwork between 2 key proteins necessary for normal development and regulation of red blood cells
7. In a first, Einstein scientists discover the dynamics of transcription in living mammalian cells
8. How cells change the pace of their steps
9. Discredited Korean embryonic stem cells true origins revealed
10. A low expression of MX2 gene exists in the white blood cells of narcoleptics
11. Penn researchers discover pathway that eliminates genetic defects in red blood cells

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/28/2020)... ... June 25, 2020 , ... In an upcoming episode scheduled for the ... of Care Testing solutions (POCT). Check local listings for more info. , Today, the ... and are shipped to labs throughout the country. Results are then available several days ...
(Date:6/23/2020)... ... 23, 2020 , ... First Aid Africa, a Scottish charity ... and manufacturer of innovative portable renewable energy equipment, have announced the success of ... COVID-19 pandemic in Zambia. , One of Renovagen’s FAST FOLD portable solar power ...
(Date:6/23/2020)... ... June 23, 2020 , ... In its June 22 online ... with Dr. James L. Sherley, M.D., Ph.D., founder and director of stem cell biotechnology ... announced on June 16 that starting July 5 it would begin offering ...
Breaking Biology News(10 mins):
(Date:8/15/2020)... Ore. (PRWEB) , ... August 13, 2020 , ... ... the creation of its Scientific Advisory Board (SAB) to research the medical potential ... cannabis can be enhanced when combined with terpenes. The board is focused on expanding ...
(Date:8/7/2020)... WOODLANDS, Texas (PRWEB) , ... August 06, 2020 ... ... therapy and DNA vaccine industries, announces it has closed on the purchase of ... Technology Park in Conroe, TX and includes over 21 acres in the initial ...
(Date:7/31/2020)... ... July 29, 2020 , ... Diversified Technologies, Inc. has introduced ... configured to drive Klystrons, TWTs, IOTs, and magnetrons. , DTI Radar Transmitter ... in a push-pull configuration; yielding fast fall time for a capacitive load. These ...
(Date:7/31/2020)... ... July 30, 2020 , ... ... the life sciences industry, today announced the release of its signature product ... Medical Science Liaisons (MSLs) and other field medical professionals. , Beacon ...
Breaking Biology Technology:
Cached News: