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Stem cells bring fast direct improvement, without differentiation, in acute renal failure

compassionate-use study in patients with severe ARF and multiorgan failure will be designed, eventually leading to clinical trials.

  • Though no adverse effects were seen in these experiments, long-term studies are needed to prove that no adverse effects occur after in vivo administration of adult MSC.

  • Also to be determined is whether renoprotective and gene-modulating effects of MSC "are primary actions that are humorally elicited by these cells or whether they result from the improvement of tissue injury by as yet unknown factors released by them."

  • Future studies "will also have to define the possible contribution to organ protection made by the immunomodulatory effects of MSC, as well as potential late phase contributions to organ repair via differentiation of stem cells into cells that have been destroyed in ARF," the study noted.


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  • 15-Aug-2005


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