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Stem cells in bone marrow replenish mouse ovaries

s. Further results suggest that the ovary itself is sending out a chemical signal to the bone marrow, readying the progenitor cells to travel to the ovary and restock its egg cell supply.

Although it is not yet clear whether the egg cells (oocytes) generated following bone marrow transplants can mature and be fertilized to give rise to viable mouse pups, the findings provide an important first step toward investigating such potential for restoring fertility. In addition, the findings open the door for future studies examining whether restoration of ovaries could postpone the hormonal effects of menopause and could represent an alternative to hormone replacement therapy. Finally, the researchers would like to find out whether these stem cells could be coaxed to produce eggs in the laboratory, potentially providing a new source of eggs for therapeutic cloning.


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Contact: Heidi Hardman
hhardman@cell.com
1-617-397-2879
Cell Press
27-Jul-2005


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