HOME >> BIOLOGY >> NEWS
Stepping up therapy for stroke and other CNS disorders

NEUROLOGY

Stroke is a major medical problem, with only very limited treatment options. In a study appearing online on July 7 in advance of print publication of the August 1 issue of the Journal of Clinical Investigation, Armin Schneider and colleagues from Axaron Biosciences describe new roles for granulocyte colony-stimulating factor (G-CSF) in treating stroke and other central nervous system roles of this protein.

The team reports that G-CSF has potent cell protective effects on mature neurons, explaining why it has been shown to be useful in animal stroke models. Moreover, G-CSF drives neuronal differentiation of adult neural stem cells in the brain, and has profound impact on long-term functional outcome after cerebral ischemia. The authors show that G-CSF itself is a neuronally expressed protein in the brain, and that systemic G-CSF can penetrate the intact blood-brain-barrier.

Thus, G-CSF is a potentially novel treatment for stroke and neurodegeneration. G-CSF doubles hippocampal neurogenesis even in normal, non-ischemic animals, making it a potential drug candidate for diseases where disturbances in neurogenesis are a factor.


'"/>

Contact: Stacie Bloom
press_releases@the-jci.org
212-342-4159
Journal of Clinical Investigation
7-Jul-2005


Page: 1

Related biology news :

1. Testosterone replacement therapy: How safe for aging men?
2. Progesterone therapy and preterm birth: More evidence helps identify women who can benefit
3. Aggressive therapy best for certain AML patients
4. Under magnetic force, nanoparticles may deliver gene therapy
5. 47th Interscience Conference on Antimicrobial Agents and Chemotherapy
6. Stem cell therapy rescues motor neurons in ALS model
7. Study identifies new gene therapy tools for inherited blindness
8. Breast cancer and hormone therapy -- A looking-glass mirror?
9. Radiation therapy combined with microsurgery shows promise for curing injured spinal cord
10. Nodal status is best predictor of outcome after neoadjuvant therapy for esophageal cancer
11. Scientists follow familiar TRAIL to new cancer therapy

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/30/2019)... ... September 30, 2019 , ... ... the capacity of life science organizations to accelerate innovation and maximize productivity, announces ... October 4th. , What: Just 30 days to 21 CFR Part 11 compliance ...
(Date:9/25/2019)... (PRWEB) , ... September 25, 2019 , ... ... in Austin, TX, have placed over 20,000 dental implants for a variety of ... highly technical zygomatic and pterygoid dental implants. Dental implants offer patients ...
(Date:9/24/2019)... ... September 23, 2019 , ... Global molecular diagnostics ... that Holotype HLA and other Omixon products will be featured among 10 posters ... for Histocompatibility and Immunogenetics (ASHI) in Pittsburgh, PA. Omixon’s Lunch Symposium on ...
Breaking Biology News(10 mins):
(Date:9/24/2019)... ... September 24, 2019 , ... ... latest research in the area of high-level X-ray methods using synchrotron-produced X-rays ... COO of Improved Pharma, will present “Synchrotron X-Ray Diffraction and Pair Distribution ...
(Date:9/24/2019)... , ... September 24, 2019 , ... ... Hannah Holscher, PhD, RD, to its Scientific Advisory Board. Dr. Holscher is an ... and the Division of Nutritional Sciences at the University of Illinois Urbana-Champaign, where ...
(Date:9/17/2019)... ... September 17, 2019 , ... Tucker, a Labrador retriever, was just a ... Tucker was limping and lame on his right hip and elbow. At one year ... called “the worst case the vet had seen.” He was prescribed pain medications, both ...
(Date:9/17/2019)... ... September 16, 2019 , ... ... CNBC on Saturday, September 21st @11:00am ET. Check local listings for more information ... (Credo Biomedical), a molecular diagnostic company from Singapore dedicated to developing advanced ...
Breaking Biology Technology:
Cached News: