Stimulating the brain makes the fingers more...( Repetitive transcranial magnetic stimul...)

Repetitive transcranial magnetic stimulation (rTMS) has emerged as an intriguing technique for exploring brain function, and a promising, though still unproven, form of therapy. This week, in the open-access journal PLoS Biology, Hubert Dinse and colleagues show that a short course of rTMS can increase finger sensitivity for up to two hours after treatment ends, and that this change corresponds to an increase in the size of the brain map representing the finger.

rTMS is applied with an electromagnetic coil in the shape of a figure-eight, placed on the scalp directly over the targeted portion of the brain. Short bursts of a strong magnetic pulse stimulate electrical currents within. Sensory input from each region of the body is represented on the surface of the brain, and the location of any region--in this case, the right index finger--can be mapped to allow precise targeting of the rTMS. The authors adjusted the strength of the magnetic field to just below that which triggered a sensory response in the finger, and then applied intermittent pulses of stimulation over the course of about ten minutes.

They tested the sensitivity of the index finger by determining how far apart two simultaneously applied pinpricks needed to be for the subject to distinguish them as separate stimuli. rTMS increased this two-point discrimination by about 15% immediately after stimulation, an effect that gradually diminished but still remained significant over the course of the next two hours. The effect was fairly specific for the right index finger: there was no effect on the left index finger, which is represented in the opposite hemisphere, and only a small effect on the right ring finger, which is represented several millimeters away from the index finger in the same hemisphere. When stimulation was applied over the area representing the lower leg, the index finger did not become more sensitive.

The authors used functional magnetic resonance imaging (fMR
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Contact: Paul Ocampo
press@plos.org
415-624-1224
Public Library of Science
17-Oct-2005

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