HOME >> BIOLOGY >> NEWS
Stomach receptor for H. pylori discovered

Bethesda, MD Scientists have determined that decay-accelerating factor (DAF), a protein found in epithelial cells in the stomach, acts as a receptor for the bacteria Helicobacter pylori. Blocking this interaction could lead to new drugs that reduce the risk of peptic ulcer disease or gastric cancer. The research appears as the "Paper of the Week" in the May 12 issue of the Journal of Biological Chemistry, an American Society for Biochemistry and Molecular Biology journal.

Helicobacter pylori are spiral shaped bacteria that live in the thick layer of mucus that covers the stomach lining. The bacteria are found everywhere in the world, but are especially prevalent in developing countries, where up to 80% of children and 90% of adults can have laboratory evidence of an H. pylori infection--usually without having any symptoms.

The vast majority of H. pylori in colonized hosts are free-living, but approximately 20% bind to gastric epithelial cells. This binding induces an immune response and alters the morphology and behavior of the epithelial cells due to injection of bacterial proteins into the cells. This interaction can lead to peptic ulcer disease, gastric adenocarcinoma, and non-Hodgkins lymphoma of the stomach.

"Ulcers are a breach in the gastric or duodenal mucosa and gastric adenocarcinoma is one type of cancer of the stomach," explains senior author Dr. Richard M. Peek, Jr. of the Vanderbilt University School of Medicine. "H. pylori alters acid production and can lead to increased acid outputs which causes peptic ulcer disease. The means through which H. pylori causes gastric cancer are more complex but likely involve alterations in gastric epithelial cell responses that are perturbed within the context of a chronic gastric inflammatory infiltrate, which can persist for decades."

A membrane-imbedded protein found in the stomach called decay-accelerating factor (DAF) has been shown to function as a receptor for several micro
'"/>

Contact: Nicole Kresge
nkresge@asbmb.org
301-634-7415
American Society for Biochemistry and Molecular Biology
4-May-2006


Page: 1 2

Related biology news :

1. Cell receptor may lead to new biomarker for pancreatic cancer
2. Menthol receptor also important in detecting cold temperatures
3. Systems characterization of cell surface receptors
4. OHSU lab finds meth receptor that could lead to therapy
5. Joslin study indicates insulin receptors play a critical role in promoting islet growth
6. Vitamin D, variations in its receptor and prostate cancer
7. Study advances evidence for receptors role in alcohol pleasure and problems
8. Longevity by a nose (or odorant receptor)
9. The G allele of the mu-opioid receptor gene is linked to craving for alcohol
10. Identification of carbon dioxide receptors in insects may help fight infectious disease
11. Researchers find docking sites for glucocorticoid receptor and Hsp90

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/22/2019)... ... 21, 2019 , ... The inventors of a new and ... major step forward with that therapy, known as SurVaxM. MimiVax LLC principals Robert ... from Roswell Park in 2012, has entered into a China-exclusive licensing agreement for ...
(Date:11/19/2019)... ... November 19, 2019 , ... Project Lifeline – ... Stores (NACDS) Foundation to address substance use disorder (SUD) – will take ... who have led to the program’s effectiveness in preventing and treating opioid abuse in ...
(Date:11/19/2019)... ... , ... The inaugural Cell & Gene Therapy Day takes place February 27, ... will be chaired by Dr Aiman Shalabi, VP R&D, Cell and Gene Therapies for ... witnessing significant innovation in cell and gene therapies, and we are at a turning ...
Breaking Biology News(10 mins):
(Date:11/6/2019)... ... November 06, 2019 , ... LeadingBiotech ,?an exclusive ... announces its East/West CEO conference to be held January 11-12, 2020 ... Kicking off the week of the J.P. Morgan Healthcare Conference and other biotech ...
(Date:11/5/2019)... ... November 05, 2019 , ... ... it has received CE Mark for its Fusion Bx 2.0 prostate fusion biopsy ... user-friendly interface, the Fusion Bx 2.0 will give urologists across Europe the ability ...
(Date:11/2/2019)... TORONTO (PRWEB) , ... October 31, 2019 , ... ... are not always used to communicating with each other: study managers, principal investigators, ... cause misunderstandings if a party is not informed of the latest data, potentially ...
(Date:11/2/2019)... ... October 31, 2019 , ... ... pharma artificial intelligence pioneer tellic. drug360 brings tellic’s expertise in biomedical language ... allows researchers to quickly uncover relationships between genes, diseases, variants, phenotypes, and other ...
Breaking Biology Technology:
Cached News: