Natural or deliberate exposure to smallpox poses a great health threat, especially since routine smallpox vaccinations have been discontinued and no clinically approved treatment currently exists. In the February 1 issue of the Journal of Clinical Investigation, Ellis Reinherz and colleagues from Harvard Medical School propose a new antiviral therapy a low molecular weight inhibitor of signaling mediated by the smallpox growth factor (SPGF).

SPGF targets the erbB-1 signaling molecule, which normally initiates an intracellular cascade that facilitates viral replication. This study shows that drugs that interfere with erbB-1 signaling inhibit SPGF-induced viral replication and spread. The authors show that treatment with these erbB-1 inhibitors are effective in lowering morbidity and mortality, and boosting T cell immunity, in infected mice.

In an accompanying commentary, Anthony Fauci and Mark Challberg from the National Institutes of Health point out that this approach "may serve to turn the tables on the virus by interfering with the very pathways that are required for viral replication and extrusion."

This study demonstrates, for the first time, that chemical inhibition of host cell signaling pathways exploited by infectious agents represents a new avenue for development of anti-viral therapeutics. These inhibitors, which are already in use in human anti-tumor therapy, may have widespread applications in human viral infections and protection from smallpox. These findings reveal a new approach to the identification and development of antiviral compounds. This is especially critical at a time when the threat of smallpox as a biological weapon is high.

'"/>

Contact: Stacie Bloom
press_releases@the-jci.org
212 342-4159
Journal of Clinical Investigation
1-Feb-2005

Page: 1
Related biology news :

1. Stopping plants from getting sick
2. Stopping smad
3. Stopping the clock: Genetics of tumor latency in skin cancer
4. Fever after smallpox vaccination tied to individual genetic variations
5. Innovative smallpox vaccine research study to be conducted at Case Medical Center
6. Mass vaccination unnecessary in the event of a large bioterrorist US smallpox attack
7. Penn researchers determine structure of smallpox virus protein bound to DNA
8. Research suggests therapy against serious side effects of smallpox vaccine
9. LIAI scientists make major finding on potential smallpox treatment
10. Secret of smallpoxs success may lead to bioterror cure
11. No serious adverse events found with next-generation smallpox vaccine