HOME >> BIOLOGY >> NEWS
Stopping the clock: Genetics of tumor latency in skin cancer

Dr. Anthony E. Oro and colleagues (Stanford University) have identified two key Gli protein degradation signals that directly affect tumor latency in a mouse model of human skin cancer.

Their paper has been made available online ahead of print and will appear on the cover of the February 1 issue of the scientific journal Genes & Development.

Gli proteins are transcriptional mediators of the Sonic Hedgehog intracellular signaling pathway. Aberrant Shh signaling is implicated in a variety of human birth defects and about 25% of human tumors. Dr. Oro and colleagues found two sequences in the Gli1 protein called Dn and Dc that are recognized by the proteasome and facilitate Gli protein destruction. Mutations in these sequences (or "degrons" as they are called) prevent Gli1 degradation, causing, rather, the Gli1 protein to accumulate, and lead to accelerated tumorigenesis.

"Although we knew inducing hedgehog signaling in cells played an important role in human cancer induction and maintenance, we were puzzled by why it took so long in many cases. We were excited to find that normal cells have a way of protecting themselves from too much of the active Gli protein and surprised to discover that cancer cells appear to have disarmed that ability."

Dr. Oro and colleagues used transgenic mice expressing various forms of the Gli1 protein to demonstrate the link between Gli1 accumulation and tumor latency. Transgenic mice expressing wild-type Gli1 (in which the degrons are completely intact) develop basal cell carcinoma (BCC)-like tumor 6-8 weeks after birth. Mice expressing an altered form of either Dn or Dc (in which Gli1 is partially stabilized) develop BCC-like lesions at an earlier age. Remarkably, mice with mutated forms of both degrons (in which Gli1 is not degraded by the proteasome) die at birth, presenting severe ulcerating skin lesions similar to human BCCs.

This work convincingly shows that Gli protein accumulation contribut
'"/>

Contact: Heather Cosel
coselpie@cshl.edu
Cold Spring Harbor Laboratory
19-Jan-2006


Page: 1 2

Related biology news :

1. Stopping plants from getting sick
2. Stopping smad
3. Stopping smallpox in its tracks: A new anti-viral approach
4. The bodys biological clock: alcohol may lead to physiological anarchy
5. The circadian clock: Understanding natures timepiece
6. 2007-2008 Genzyme/ACMGF Clinical Genetics Fellowship In Biochemical Genetics award winner announced
7. Maynard Olson receives $500,000 Gruber Genetics Prize
8. Cell Press announces new partnership with the American Society of Human Genetics
9. Health disparities -- Genetics, society and race play an important role in access to healthcare
10. Research and program highlights of the 2007 Annual Clinical Genetics Meeting, March 21-25, 2007
11. Nature Genetics and the International Society of Nephrology come to Danvers on World Kidney Day

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/13/2019)... EGG HARBOR, N.J. (PRWEB) , ... March 13, 2019 , ... ... detection systems for the Pharmaceutical, Biotechnology and Medical Device Industries, is excited to announce ... changed ownership in early February 2019 and the newly installed and highly experienced ...
(Date:3/11/2019)... ... 11, 2019 , ... A new report published by the Family Equality Council ... 77% of those aged 18 to 35 already have or are considering having children, ... and older.(1) Among all LGBTQ prospective parents, 41% are considering assisted reproductive technology (ART) ...
(Date:3/9/2019)... MURRIETA, Calif. (PRWEB) , ... March 07, 2019 , ... ... sponsor of a full day workshop presented by University of California Riverside’s ... being held from 8 a.m. to 6 p.m. on Tuesday, March 17, 2019. The ...
Breaking Biology News(10 mins):
(Date:3/12/2019)... (PRWEB) , ... March 11, 2019 , ... ... first hospital system in Colorado, and among the first in the nation, to ... around lab draws, IV placement and overall degree to which staff showed compassion ...
(Date:3/9/2019)... ... March 07, 2019 , ... ACEA Biosciences Inc. ... and commercialization of high performance, cutting-edge cell analysis platforms for life science research. ... expertise in cardiovascular pharmacology and electrophysiology, are announcing a partnership to provide comprehensive ...
(Date:3/4/2019)... ... 04, 2019 , ... Stay on top of current hot topics through free webinars presented by ... free, so be sure to register today to save your place! Participate in the discussion ... webinars: , CLINICAL TRIALS, , March 20 – Implementing BYOD Across ...
(Date:2/22/2019)... , ... February 20, 2019 , ... ... SeqOnce , an emerging leader in the rapidly growing NGS (Next Generation Sequencing) ... the Murrieta Genomics laboratory and incubator. , "As an innovation center and idea ...
Breaking Biology Technology:
Cached News: