Articles to be published in the June 1, 2007 issue of the Journal of Biological Chemistry (Vol. 282, No. 22)
New Insight into Cell Division
This article was featured as a "Paper of the Week" by the Journal of Biological Chemistry's Editors, meaning that it belongs to the top one percent of papers reviewed in significance and overall importance.
Researchers provide new details about how proteins orchestrate cell division.
Cells can divide only when certain key proteins are activated and others inhibited. A protein called NIPA and a set of two proteins called cyclin B1 and Cdk1 are some of these key proteins. Until now, scientists had shown that the cyclin B1/Cdk1 complex is needed to initiate and maintain cell division but is destroyed before and after this process. Also, NIPA was shown to regulate the abundance of cyclin B1/Cdk1 before cell division.
Justus Duyster, Florian Bassermann, and their colleagues revealed that cyclin B1/Cdk1 also regulates NIPA during cell division, which indicates that both proteins regulate each other. The scientists suggest that NIPA is inhibited twice: directly before cell division, to activate cyclin B1/Cdk1, and at the beginning of cell division, when NIPA is further inhibited by cyclin B1/Cdk1. At the end of cell division, cyclin B1/Cdk1 is destroyed and NIPA becomes active again.
Article: "Multisite phosphorylation of Nuclear Interaction Partner of ALK (NIPA) at G2/M Involves Cyclin B1/Cdk1" by Florian Bassermann, Christine von Klitzing, Anna Lena Illert, Silvia Muench, Stephan W. Morris, Michele Pagano, Christian Peschel, and Justus D
Contact: Pat Pages
American Society for Biochemistry and Molecular Biology