HOME >> BIOLOGY >> NEWS
Story ideas from the Journal of Lipid Research

Articles to be published in the June 2007 issue of the Journal of Lipid Research (Vol. 48, No. 6)

ARTICLE HIGHLIGHTS

  • New insight into how low HDL causes heart disease
  • Too much of a key protein observed in type 2 diabetes patients
  • Thematic Review: How fat tissue works


New insight into how low HDL causes heart disease

Researchers have found that one of the reasons people with low HDL a molecule that helps eliminate excess cholesterol from arteries are at risk of developing heart disease could be a defective version of a protein called ABCA1.

People with familial low HDL, or hypolipoproteinemia, have an impaired ability to transport cholesterol out of their cells, which leads to an accumulation of cholesterol in many tissues. For some of these individuals, the disease is due to mutations in proteins called ATP-binding cassettes (ABCs) that transport lipids and other molecules inside and outside cells, but for many affected individuals, the causes of the disease is still not well known.

Marja-Riitta Taskinen and colleagues examined how the first steps of the transport of cholesterol into the liver were disturbed in individuals with familial low HDL. The scientists compared the gene expression of ABC proteins in low HDL and control subjects and found that the genetic expression of ABC proteins was increased in low HDL subjects, indicating that these ABC proteins may be abnormally produced in the affected individuals.

Article: "Common ABCA1 variants, HDL levels and cellular cholesterol efflux in subjects with Familial low-HDL," by Aino Soro-Paavonen1, Jussi Naukkarinen, Miriam Lee-Rueckert, Hiroshi Watanabe, Elina Rantala, Sanni Soderlund, Anne Hiukka, Petri T Kovanen, Matti Jauhiainen, Leena Peltonen, and Marja-Riitta Taskinen

MEDI
'"/>

Contact: Pat Pages
ppages@asbmb.org
301-634-7366
American Society for Biochemistry and Molecular Biology
29-May-2007


Page: 1 2 3 4

Related biology news :

1. Story tips from the US Department of Energys Oak Ridge National Laboratory, August 2007
2. Story tips from the Department of Energys Oak Ridge National Laboratory
3. Story ideas from Molecular & Cellular Proteomics
4. Story ideas from the Journal of Biological Chemistry
5. Story ideas from the Journal of Lipid Research
6. Story tips from the Department of Energys Oak Ridge National Laboratory, April 2007
7. Story tips from the Department of Energys Oak Ridge National Laboratory, March 2007
8. Story tips from the Department of Energys Oak Ridge National Laboratory
9. Story tips from the Department of Energys Oak Ridge National Laboratory, January 2007
10. Story tips from the Department of Energys Oak Ridge National Laboratory, November 2006
11. Story tips from the Department of Energys Oak Ridge National Laboratory, October 2006

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/2/2016)... 2016 The Department of Transport Management ... 44 million US Dollar project, for the , ... Personalization, Enrolment, and IT Infrastructure , to ... and implementation of Identity Management Solutions. Numerous renowned international vendors ... Decatur was selected for the most compliant and ...
(Date:5/20/2016)...  VoiceIt is excited to announce its new ... By working together, VoiceIt and VoicePass will offer ... take slightly different approaches to voice biometrics, collaboration ... usability. Both ... "This marketing and technology partnership allows ...
(Date:4/28/2016)... and BANGALORE, India , April 28, 2016 ... a product subsidiary of Infosys (NYSE: INFY ), ... a global partnership that will provide end customers ... mobile banking and payment services.      (Logo: ... innovation area for financial services, but it also plays a ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... June 27, 2016 /PRNewswire/ - BIOREM Inc. (TSX-V: BRM) ("Biorem" ... by its major shareholders, Clean Technology Fund I, LP ... States based venture capital funds which together ... (on a fully diluted, as converted basis), that they ... their entire equity holdings in Biorem to TUS Holdings ...
(Date:6/27/2016)... ... 2016 , ... Newly created 4Sight Medical Solutions ... healthcare market. The company's primary focus is on new product introductions, to include ... are necessary to help companies efficiently bring their products to market. , The ...
(Date:6/24/2016)... 2016  Regular discussions on a range of subjects including ... two entities said Poloz. Speaking at a lecture ... , he pointed to the country,s inflation target, which is ... "In certain areas there ... common economic goals, why not sit down and address strategy ...
(Date:6/23/2016)... WA (PRWEB) , ... June 23, 2016 , ... ... announces the release of its second eBook, “Clinical Trials Patient Recruitment and Retention ... recruitment and retention in this eBook by providing practical tips, tools, and strategies ...
Breaking Biology Technology:
Cached News: