HOME >> BIOLOGY >> NEWS
Story ideas from the Journal of Lipid Research

Articles to be published in the June 2007 issue of the Journal of Lipid Research (Vol. 48, No. 6)

ARTICLE HIGHLIGHTS

  • New insight into how low HDL causes heart disease
  • Too much of a key protein observed in type 2 diabetes patients
  • Thematic Review: How fat tissue works


New insight into how low HDL causes heart disease

Researchers have found that one of the reasons people with low HDL a molecule that helps eliminate excess cholesterol from arteries are at risk of developing heart disease could be a defective version of a protein called ABCA1.

People with familial low HDL, or hypolipoproteinemia, have an impaired ability to transport cholesterol out of their cells, which leads to an accumulation of cholesterol in many tissues. For some of these individuals, the disease is due to mutations in proteins called ATP-binding cassettes (ABCs) that transport lipids and other molecules inside and outside cells, but for many affected individuals, the causes of the disease is still not well known.

Marja-Riitta Taskinen and colleagues examined how the first steps of the transport of cholesterol into the liver were disturbed in individuals with familial low HDL. The scientists compared the gene expression of ABC proteins in low HDL and control subjects and found that the genetic expression of ABC proteins was increased in low HDL subjects, indicating that these ABC proteins may be abnormally produced in the affected individuals.

Article: "Common ABCA1 variants, HDL levels and cellular cholesterol efflux in subjects with Familial low-HDL," by Aino Soro-Paavonen1, Jussi Naukkarinen, Miriam Lee-Rueckert, Hiroshi Watanabe, Elina Rantala, Sanni Soderlund, Anne Hiukka, Petri T Kovanen, Matti Jauhiainen, Leena Peltonen, and Marja-Riitta Taskinen

MEDI
'"/>

Contact: Pat Pages
ppages@asbmb.org
301-634-7366
American Society for Biochemistry and Molecular Biology
29-May-2007


Page: 1 2 3 4

Related biology news :

1. Story tips from the US Department of Energys Oak Ridge National Laboratory, August 2007
2. Story tips from the Department of Energys Oak Ridge National Laboratory
3. Story ideas from Molecular & Cellular Proteomics
4. Story ideas from the Journal of Biological Chemistry
5. Story ideas from the Journal of Lipid Research
6. Story tips from the Department of Energys Oak Ridge National Laboratory, April 2007
7. Story tips from the Department of Energys Oak Ridge National Laboratory, March 2007
8. Story tips from the Department of Energys Oak Ridge National Laboratory
9. Story tips from the Department of Energys Oak Ridge National Laboratory, January 2007
10. Story tips from the Department of Energys Oak Ridge National Laboratory, November 2006
11. Story tips from the Department of Energys Oak Ridge National Laboratory, October 2006

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Story ideas from the Journal Lipid Research

(Date:7/8/2015)... , July 8, 2015 Summary ... and the fourth most fatal, with a mortality rate ... poor prognosis of pancreatic cancer patients has highlighted a ... which is not being met by the current market. ... array of products with varying molecule types and mechanisms ...
(Date:7/7/2015)... , July 7, 2015  Based on its ... & Sullivan recognizes Credence ID, LLC with the ... Company of the Year Award. Credence ID has ... in its mission of offering enrollment and identification ... As Credence ID was formed by experts from ...
(Date:6/30/2015)... , June 30, 2015 To bolster its ... provider HYPR Corp. announced today the addition of two new ... serve as board advisor and David Raviv will ... team underscore HYPR Corp.,s commitment to providing the most secure ... Dimitri Sirota co-founded Layer 7 Technologies, a provider of ...
Breaking Biology News(10 mins):Frontier Pharma: Pancreatic Cancer - Identifying and Commercializing First-in-Class Innovation 2Frontier Pharma: Pancreatic Cancer - Identifying and Commercializing First-in-Class Innovation 3Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 2Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 3Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 4Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 5HYPR Corp. Expands Biometric Authentication Team with Enterprise All Stars 2HYPR Corp. Expands Biometric Authentication Team with Enterprise All Stars 3
(Date:7/30/2015)... VANCOUVER, Washington , July 30, 2015 ... "Biosimulation Market, by Product (Software, Molecular Modeling, PB/PK, PKPD, ... (Drug Discovery & Development, Preclinical, Clinical Trial), by End ... the Biosimulation Market is expected to reach USD 2,107.99 ... at a CAGR of 15.29%. Browse ...
(Date:7/30/2015)... over 60,000 customers across the globe, ISN improves the efficiency and effectiveness of contractor ... 60,000 safe and reliable contractors in over 80 countries. ... ... Over 60,000 Worldwide Customers In More Than ... Headquartered in Dallas, TX , ISN has additional offices in ...
(Date:7/30/2015)... York, NY (PRWEB) , ... July 30, 2015 , ... As part of its 2015 ... raw material and technical service business units, Whitehouse Laboratories is pleased to ... will be adjacent to the Container Center of Excellence and will be strictly dedicated to ...
(Date:7/29/2015)... , July 30, 2015 According ... Market - Growth, Trends & Forecasts (2015-2020), , published by ... US$ 30.25 billion by the end of 2020, with ... accounting for more than 40% of the global market size. ... at a CAGR of 13.7% during the period of (2015-2020). ...
Breaking Biology Technology:Biosimulation Market Worth 2,107.99 Million USD by 2020 2Biosimulation Market Worth 2,107.99 Million USD by 2020 3Biosimulation Market Worth 2,107.99 Million USD by 2020 4ISN Reaches Over 60,000 Worldwide Customers 2ISN Reaches Over 60,000 Worldwide Customers 3Whitehouse Labs Formally Announces Plans to Open a Microbiological Laboratory 2Asia Pacific to Dominate the Global Stem Cell Market - Vericel Corporation, Ocata Therpeutics, Athersys Inc., Cryo-Cell International, Geron Corporation, StemCells, Inc. Among the Major Players 2Asia Pacific to Dominate the Global Stem Cell Market - Vericel Corporation, Ocata Therpeutics, Athersys Inc., Cryo-Cell International, Geron Corporation, StemCells, Inc. Among the Major Players 3
Cached News: