HOME >> BIOLOGY >> NEWS
Stowers Institute's Workman Lab demonstrates mechanism for decoding histone modification marks

Jerry Workman, Ph.D., Investigator, and Bing Li, Ph.D., Senior Research Associate in the Workman Lab, have published evidence demonstrating that a combinatorial action of multiple protein domains is required to read a histone modification.

Published in today's issue of Science, their paper, "Combined action of PHD and Chromo domains directs the Rpd3S complex to deacetylate transcribed chromatin," used a novel approach that allowed the team to measure the protein complex binding to modified chromatin.

"When cells transcribe genes, that part of the chromosome is opened and susceptible to inappropriate use. Cells demarcate transcribed regions of chromosomes with a landmark the lysine 36 methylation of histone H3," explains Dr. Li. "We found that combination of two critical protein domains within a histone deacetylase complex is essential for its recruitment to this modified chromatin in transcribed regions. This specific recognition re-closes the chromosome and ensures genome integrity during active transcription and maintains accurate transcription initiation."

Within chromatin-related complexes, compact structural parts of a protein, called "domains," are able to recognize specific histone modifications. However, until now it was unclear how such domains could target the correct protein complex to a specific site in the chromosome. In this case it takes the combined action of two protein domains to target the complexes to transcribe chromatin to re-close its structure.

The findings bear significantly on the understanding of Huntington's disease, which is marked by genetically programmed degeneration of neurons in certain areas of the brain.

"The histone modification we focused on in this study, K36 methylation, is catalyzed by the human protein HYPB that interacts with the Huntington's disease protein known as huntingtin," said Dr. Workman. "Our findings may one day assist in the design of therapeutic or preve
'"/>

Contact: Marie Jennings
mfj@stowers-institute.org
816-926-4015
Stowers Institute for Medical Research
18-May-2007


Page: 1 2

Related biology news :

1. Stowers Institute scientist named Searle Scholar
2. Stowers scientists clarify role of tumor suppressor gene
3. Stowers scientists demonstrate mechanism of vertebral formation
4. Fourth Stowers researcher awarded Basil OConnor Award
5. Stowers researcher answers fundamental question of cell death
6. Stowers researcher publishes DNA double-strand break repair discovery in Science
7. Stowers Institute scientist named American Cancer Society research professor
8. New study demonstrates important role of glia in circadian timing
9. BEMA Fentanyl demonstrates substantial transmucosal delivery
10. Xie Lab demonstrates the role of microRNA pathway
11. Rong Li Lab demonstrates the process of mammalian egg maturation

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/17/2019)... ... July 18, 2019 , ... ... Meredith James, HT, PMP, to its executive team as Vice President of Operations. ... drug development. In her new role, Ms. James is responsible for ensuring on-time ...
(Date:7/17/2019)... ... 15, 2019 , ... RCH Solutions (RCH), a ... companies, announces the availability of new specialty advisory practice, a Public Cloud Managed ... emerging bio-pharma companies interested in achieving specific outcomes related to public Cloud adoption. ...
(Date:7/17/2019)... ... ... Imagine using a simple, portable test to detect cancer before malignant tissues ... South Dakota School of Mines & Technology researcher Congzhou Wang, Ph.D., these ideas are ... to monitor and prevent disease,” says Wang. , Wang, an assistant professor in ...
Breaking Biology News(10 mins):
(Date:7/11/2019)... ... July 11, 2019 , ... At the most recent stem cell ... eight military Veterans under the R3 Heroes Program. The Veterans included individuals and families ... Program allow anyone to nominate a military Veteran, teacher or first responder to receive ...
(Date:7/9/2019)... ... July 08, 2019 , ... Balluff has been ... recognized as the 2019 Innovative Product of the Year which highlights cutting-edge advancements ... during Sensors Expo & Conference 2019, held this week in San ...
(Date:6/26/2019)... ... June 26, 2019 , ... Alice Branton today released ... improving physicochemical properties of Magnesium Gluconate, which can prove to be beneficial for treating ... of characteristic differentiation peak, change in crystallite size , Over 142% increase ...
(Date:6/18/2019)... ... ... Personalized Stem Cells, Inc (“PSC”), a human adipose-derived stem cell company, ... a person’s own adipose-derived stem cells to treat their osteoarthritis. The first clinical trial ... is the first of several planned clinical trials which will enable qualified PSC-enrolled physicians ...
Breaking Biology Technology:
Cached News: