HOME >> BIOLOGY >> NEWS
Stowers Institute's Workman Lab demonstrates mechanism for decoding histone modification marks

Jerry Workman, Ph.D., Investigator, and Bing Li, Ph.D., Senior Research Associate in the Workman Lab, have published evidence demonstrating that a combinatorial action of multiple protein domains is required to read a histone modification.

Published in today's issue of Science, their paper, "Combined action of PHD and Chromo domains directs the Rpd3S complex to deacetylate transcribed chromatin," used a novel approach that allowed the team to measure the protein complex binding to modified chromatin.

"When cells transcribe genes, that part of the chromosome is opened and susceptible to inappropriate use. Cells demarcate transcribed regions of chromosomes with a landmark the lysine 36 methylation of histone H3," explains Dr. Li. "We found that combination of two critical protein domains within a histone deacetylase complex is essential for its recruitment to this modified chromatin in transcribed regions. This specific recognition re-closes the chromosome and ensures genome integrity during active transcription and maintains accurate transcription initiation."

Within chromatin-related complexes, compact structural parts of a protein, called "domains," are able to recognize specific histone modifications. However, until now it was unclear how such domains could target the correct protein complex to a specific site in the chromosome. In this case it takes the combined action of two protein domains to target the complexes to transcribe chromatin to re-close its structure.

The findings bear significantly on the understanding of Huntington's disease, which is marked by genetically programmed degeneration of neurons in certain areas of the brain.

"The histone modification we focused on in this study, K36 methylation, is catalyzed by the human protein HYPB that interacts with the Huntington's disease protein known as huntingtin," said Dr. Workman. "Our findings may one day assist in the design of therapeutic or preve
'"/>

Contact: Marie Jennings
mfj@stowers-institute.org
816-926-4015
Stowers Institute for Medical Research
18-May-2007


Page: 1 2

Related biology news :

1. Stowers Institute scientist named Searle Scholar
2. Stowers scientists clarify role of tumor suppressor gene
3. Stowers scientists demonstrate mechanism of vertebral formation
4. Fourth Stowers researcher awarded Basil OConnor Award
5. Stowers researcher answers fundamental question of cell death
6. Stowers researcher publishes DNA double-strand break repair discovery in Science
7. Stowers Institute scientist named American Cancer Society research professor
8. New study demonstrates important role of glia in circadian timing
9. BEMA Fentanyl demonstrates substantial transmucosal delivery
10. Xie Lab demonstrates the role of microRNA pathway
11. Rong Li Lab demonstrates the process of mammalian egg maturation

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/19/2017)... York , April 19, 2017 ... as its vendor landscape is marked by the presence ... market is however held by five major players - ... Together these companies accounted for nearly 61% of the ... the leading companies in the global military biometrics market ...
(Date:4/13/2017)... According to a new market research report "Consumer IAM Market ... Authorization), Service, Authentication Type, Deployment Mode, Vertical, and Region - Global Forecast ... from USD 14.30 Billion in 2017 to USD 31.75 Billion by 2022, ... ... MarketsandMarkets Logo ...
(Date:4/11/2017)... MELBOURNE, Florida , April 11, 2017 ... "Company"), a security technology company, announces the appointment of independent ... John Bendheim to its Board of Directors, furthering the ... ... behalf of NXT-ID, we look forward to their guidance and ...
Breaking Biology News(10 mins):
(Date:9/20/2017)... ... , ... From industry leaders, sports stars, and Hollywood icons to thousands of ... people had lost all hope. Their stories are told here. , Chapter ... , “Neil takes readers on a riveting journey through the past, present and future ...
(Date:9/19/2017)... ... 2017 , ... A best-selling author and an international law ... Angela Duckworth and her team at Character Lab have joined Philadelphia’s ic@3401 as ... firm with decades of experience supporting high-growth companies in the technology and life ...
(Date:9/19/2017)... ... 19, 2017 , ... Avomeen Analytical Services, an Ann Arbor ... Science Student Award. The scholarship program is dedicated to helping those who demonstrate ... costs of obtaining their science education. , Avomeen began the annual scholarship program ...
(Date:9/18/2017)... USA, and CARDIFF, UK (PRWEB) , ... September ... ... for optics and photonics, has announced the move of the SPIE Digital Library ... , Developed internally by SPIE to create an improved user experience and incorporate ...
Breaking Biology Technology:
Cached News: