HOME >> BIOLOGY >> NEWS
Stowers Institute's Workman Lab demonstrates mechanism for decoding histone modification marks

Jerry Workman, Ph.D., Investigator, and Bing Li, Ph.D., Senior Research Associate in the Workman Lab, have published evidence demonstrating that a combinatorial action of multiple protein domains is required to read a histone modification.

Published in today's issue of Science, their paper, "Combined action of PHD and Chromo domains directs the Rpd3S complex to deacetylate transcribed chromatin," used a novel approach that allowed the team to measure the protein complex binding to modified chromatin.

"When cells transcribe genes, that part of the chromosome is opened and susceptible to inappropriate use. Cells demarcate transcribed regions of chromosomes with a landmark the lysine 36 methylation of histone H3," explains Dr. Li. "We found that combination of two critical protein domains within a histone deacetylase complex is essential for its recruitment to this modified chromatin in transcribed regions. This specific recognition re-closes the chromosome and ensures genome integrity during active transcription and maintains accurate transcription initiation."

Within chromatin-related complexes, compact structural parts of a protein, called "domains," are able to recognize specific histone modifications. However, until now it was unclear how such domains could target the correct protein complex to a specific site in the chromosome. In this case it takes the combined action of two protein domains to target the complexes to transcribe chromatin to re-close its structure.

The findings bear significantly on the understanding of Huntington's disease, which is marked by genetically programmed degeneration of neurons in certain areas of the brain.

"The histone modification we focused on in this study, K36 methylation, is catalyzed by the human protein HYPB that interacts with the Huntington's disease protein known as huntingtin," said Dr. Workman. "Our findings may one day assist in the design of therapeutic or preve
'"/>

Contact: Marie Jennings
mfj@stowers-institute.org
816-926-4015
Stowers Institute for Medical Research
18-May-2007


Page: 1 2

Related biology news :

1. Stowers Institute scientist named Searle Scholar
2. Stowers scientists clarify role of tumor suppressor gene
3. Stowers scientists demonstrate mechanism of vertebral formation
4. Fourth Stowers researcher awarded Basil OConnor Award
5. Stowers researcher answers fundamental question of cell death
6. Stowers researcher publishes DNA double-strand break repair discovery in Science
7. Stowers Institute scientist named American Cancer Society research professor
8. New study demonstrates important role of glia in circadian timing
9. BEMA Fentanyl demonstrates substantial transmucosal delivery
10. Xie Lab demonstrates the role of microRNA pathway
11. Rong Li Lab demonstrates the process of mammalian egg maturation

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/29/2016)... Nov. 29, 2016   Neurotechnology , ... object recognition technologies, today released FingerCell 3.0, ... recognition solutions that run on low-power, low-memory ... using less than 128KB of memory, enabling ... that have limited on-board resources, such as: ...
(Date:11/28/2016)... 28, 2016 "The biometric ... 16.79%" The biometric system market is in the ... the near future. The biometric system market is expected ... at a CAGR of 16.79% between 2016 and 2022. ... biometric technology in smartphones, rising use of biometric technology ...
(Date:11/22/2016)... According to the new market research report "Biometric System Market by Authentication ... (Hardware and Software), Function (Contact and Non-contact), Application, and Region - Global ... from USD 10.74 Billion in 2015 to reach USD 32.73 Billion by ... Continue Reading ... ...
Breaking Biology News(10 mins):
(Date:11/30/2016)... TORONTO , Nov. 30, 2016 /PRNewswire/ - Portage ... Canadian Securities Exchange: PBT.U), is excited to announce ... company focused on developing preclinical ophthalmology assets through ... a potent anti-inflammatory created by Portage Pharmaceuticals Limited ... patients with ocular surface and anterior segment diseases. ...
(Date:11/30/2016)... CHICAGO , Nov. 30, 2016  Tempus, ... customized cancer care, and Penn,s Abramson Cancer Center ... have a positive response to immunotherapy treatment based ... As part of a research collaboration, ... pancreatic and melanoma cancer patient data to Penn. ...
(Date:11/30/2016)... 2016   Merck , a leading science and ... a set of agreements with Evotec AG, whereby Evotec ... genetic reagents such as CRISPR and shRNA libraries. Combining ... an accelerated pathway to explore and identify new drug ... of new targets, a process that can be time- ...
(Date:11/30/2016)... ... 2016 , ... On 28 November 2016, the International Union of Pure and ... moscovium (Mc), tennessine (Ts), and oganesson (Og), respectively for element 113, 115, 117, and ... the discoverers have been approved by the IUPAC Bureau. The IUPAC Council will be ...
Breaking Biology Technology:
Cached News: