HOME >> BIOLOGY >> NEWS
Stowers researcher answers fundamental question of cell death

Kansas City, MO. (Jan.10 2005) Chunying Du, Ph.D., Assistant Investigator at the Stowers Institute, has published findings that reveal a previously unknown pathway of Bruce, the gene encoding a protein that inhibits apoptosis, or programmed cell death.

The findings are available online at www.pnas.org/cgi/reprint/0408744102v1 and will be published in the Jan. 18 issue of Proceedings of the National Academy of Sciences (PNAS).

Bruce has long been recognized as an inhibitor of apoptosis, but until now, its method of inhibition was not clear. Dr. Du analyzed Bruce mutant mice and found that Bruce regulates p53, a tumor suppressor gene, and the mitochondrial pathway of apoptosis.

Bruce's primary function resides upstream of mitochondria. Loss of function of Bruce increases the level of p53, making cells more sensitive to apoptosis. The transcriptional activity of p53 is responsible for the activation of genes including Pidd, Bax, and Bak. These in turn activate mitochondria, leading to apoptosis.

"The identification of Bruce as a regulator of p53 raises the possibility that therapeutic inactivation of Bruce activity could keep p53 levels high to combat certain tumors," said Dr. Du. "On the other hand, over expression of Bruce may help maintain cell survival in neurodegenerative diseases such as Alzheimer's disease." "Dr. Du's findings answer a fundamental question of apoptosis and have implications for a wide variety diseases," says Robb Krumlauf, Ph.D., Scientific Director of the Stowers Institute. "These findings are an example of the broad impact of basic research conducted at the Stowers Institute."

Dr. Du joined the Stowers Institute in 2001. She holds B.S. and M.S. degrees from Beijing Normal University, and a Ph.D. from Iowa State University. From 1998 to 2001, she was a Howard Hughes Medical Institute Postdoctoral Fellow with Dr. Xiaodong Wang
'"/>

Contact: Marie Jennings
mfj@stowers-institute.org
816-926-4015
Stowers Institute for Medical Research
10-Jan-2005


Page: 1 2

Related biology news :

1. Stowers Institutes Workman Lab demonstrates mechanism for decoding histone modification marks
2. Stowers Institute scientist named Searle Scholar
3. Stowers scientists clarify role of tumor suppressor gene
4. Stowers scientists demonstrate mechanism of vertebral formation
5. Fourth Stowers researcher awarded Basil OConnor Award
6. Stowers researcher publishes DNA double-strand break repair discovery in Science
7. Stowers Institute scientist named American Cancer Society research professor
8. Innovative tagging technique may help researchers better protect fish stocks
9. Penn researchers discover how key protein stops inflammation
10. ASU researchers partner with UOP to make biofuel for military jets a reality
11. Einstein researchers prototype vaccine could provide improved protection against tuberculosis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/13/2017)... SAN FRANCISCO , Feb. 13, 2017 /PRNewswire/ ... a centralized platform that is designed to enhance ... the latest release in the RSA Fraud & ... to enable organizations to leverage additional insights from ... anti-fraud tools to better protect their customers from ...
(Date:2/9/2017)... , Feb. 9, 2017 The biomass ... analysis of the biomass boiler market globally in terms ... of biomass boilers. The market for biomass boilers has ... type, end-user, application, and country/region. The market based on ... & forest residues, biogas & energy crops, urban residues, ...
(Date:2/8/2017)... Report Highlights ... The global synthetic-biology market reached nearly $3.9 ... growing at a compound annual growth rate (CAGR) of 24.0% ... global markets for synthetic biology. - Analyses of global market ... of compound annual growth rates (CAGRs) through 2021. - Coverage ...
Breaking Biology News(10 mins):
(Date:2/23/2017)... , Feb. 23, 2017  In Atlanta, it seems everyone ... and culture intertwine to create an expressive and dynamic community ... this energy and contribute to it. With ... Hair Fairies seeks to carry on that tradition with ... Atlanta salon is the newest of 13 ...
(Date:2/23/2017)... INDIANAPOLIS, Ind. (PRWEB) , ... February 23, 2017 ... ... Commercialization Award during the 12th annual Inventors Recognition Reception at Purdue Research ... annually to a faculty member in recognition of outstanding contributions to, and success ...
(Date:2/23/2017)... and SAN FRANCISCO , ... privately-held regenerative medicine company, and Beyond Type 1, a ... type 1 diabetes, today announced a grant from Beyond ... functional cure for type 1 and other insulin-requiring diabetes.  ... has been developing innovative stem cell-derived cell replacement therapies ...
(Date:2/22/2017)... Feb. 22, 2017  PrimeVax Immuno-Oncology, Inc. announced today ... at the Annual Biocom Global Life Science Partnering Conference.  ... 11:15 AM, at the Torrey Pines Lodge, in San ... organizers at Biocom who have chosen our company, amongst ... biotechnology companies, investors, and clinical researchers," said Mr. Chen. ...
Breaking Biology Technology:
Cached News: