Stowers researcher answers fundamental question of cell death

Kansas City, MO. (Jan.10 2005) Chunying Du, Ph.D., Assistant Investigator at the Stowers Institute, has published findings that reveal a previously unknown pathway of Bruce, the gene encoding a protein that inhibits apoptosis, or programmed cell death.

The findings are available online at www.pnas.org/cgi/reprint/0408744102v1 and will be published in the Jan. 18 issue of Proceedings of the National Academy of Sciences (PNAS).

Bruce has long been recognized as an inhibitor of apoptosis, but until now, its method of inhibition was not clear. Dr. Du analyzed Bruce mutant mice and found that Bruce regulates p53, a tumor suppressor gene, and the mitochondrial pathway of apoptosis.

Bruce's primary function resides upstream of mitochondria. Loss of function of Bruce increases the level of p53, making cells more sensitive to apoptosis. The transcriptional activity of p53 is responsible for the activation of genes including Pidd, Bax, and Bak. These in turn activate mitochondria, leading to apoptosis.

"The identification of Bruce as a regulator of p53 raises the possibility that therapeutic inactivation of Bruce activity could keep p53 levels high to combat certain tumors," said Dr. Du. "On the other hand, over expression of Bruce may help maintain cell survival in neurodegenerative diseases such as Alzheimer's disease." "Dr. Du's findings answer a fundamental question of apoptosis and have implications for a wide variety diseases," says Robb Krumlauf, Ph.D., Scientific Director of the Stowers Institute. "These findings are an example of the broad impact of basic research conducted at the Stowers Institute."

Dr. Du joined the Stowers Institute in 2001. She holds B.S. and M.S. degrees from Beijing Normal University, and a Ph.D. from Iowa State University. From 1998 to 2001, she was a Howard Hughes Medical Institute Postdoctoral Fellow with Dr. Xiaodong Wang

Contact: Marie Jennings
Stowers Institute for Medical Research

Page: 1 2

Related biology news :

1. Stowers Institutes Workman Lab demonstrates mechanism for decoding histone modification marks
2. Stowers Institute scientist named Searle Scholar
3. Stowers scientists clarify role of tumor suppressor gene
4. Stowers scientists demonstrate mechanism of vertebral formation
5. Fourth Stowers researcher awarded Basil OConnor Award
6. Stowers researcher publishes DNA double-strand break repair discovery in Science
7. Stowers Institute scientist named American Cancer Society research professor
8. Innovative tagging technique may help researchers better protect fish stocks
9. Penn researchers discover how key protein stops inflammation
10. ASU researchers partner with UOP to make biofuel for military jets a reality
11. Einstein researchers prototype vaccine could provide improved protection against tuberculosis

Post Your Comments:

(Date:4/13/2016)... 2016  IMPOWER physicians supporting Medicaid patients in ... clinical standard in telehealth thanks to a new partnership ... platform, IMPOWER patients can routinely track key health measurements, ... index, and, when they opt in, share them with ... a local retail location at no cost. By leveraging ...
(Date:3/29/2016)... 2016 LegacyXChange, Inc. (OTC: ... SelectaDNA/CSI Protect are pleased to announce our successful effort ... variety of writing instruments, ensuring athletes signatures against counterfeiting ... from athletes on LegacyXChange will be assured of ongoing ... Bill Bollander , CEO states, "By ...
(Date:3/22/2016)... and SANDY, Utah , March ... operates the highest sample volume laboratory in ... and UNIConnect, leaders in clinical sequencing informatics and molecular ... of a project to establish the informatics infrastructure for ... NSO has been contracted by the Ontario Ministry ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... 23, 2016   Boston Biomedical , an ... designed to target cancer stemness pathways, announced that ... Orphan Drug Designation from the U.S. Food and ... cancer, including gastroesophageal junction (GEJ) cancer. Napabucasin is ... inhibit cancer stemness pathways by targeting STAT3, and ...
(Date:6/23/2016)... 2016 Houston Methodist Willowbrook Hospital has ... Association to serve as their official health care ... Willowbrook will provide sponsorship support, athletic training services, ... coaches, volunteers, athletes and families. "We ... Association and to bring Houston Methodist quality services ...
(Date:6/23/2016)... NEW YORK , June, 23, 2016  The ... students to envision new ways to harness living systems ... of Modern Art (MoMA) in New York ... more than 130 participating students, showcased projects at MoMA,s ... included Paola Antonelli , MoMA,s senior curator of ...
(Date:6/23/2016)... ON (PRWEB) , ... June 23, 2016 , ... STACS ... DNA Technical Leader at the Arkansas State Crime Laboratory, has joined STACS DNA as ... the STACS DNA team,” said Jocelyn Tremblay, President and COO of STACS DNA. “In ...
Breaking Biology Technology:
Cached News: