HOME >> BIOLOGY >> NEWS
Stowers researcher publishes DNA double-strand break repair discovery in Science

KANSAS CITY, MO. (Dec. 16, 2004) - Thomas Kusch, Ph.D., a Senior Research Associate at the Stowers Institute working with Investigator Jerry Workman, Ph.D., has identified a histone-modifying complex from Drosophila melanogaster (fruit flies), which facilitates DNA double-strand repair by locally increasing DNA accessibility at sites of damage.

The findings are available in the Dec. 17 issue of Science.

"DNA double strand breaks are regarded as one of the primary causes of cancer," says Kusch. "While there are natural mechanisms within an organism to detect and repair these breaks, factors involved in DNA damage repair must first bypass histones. Histones are proteins that condense DNA and protect it from mechanical and other stresses, but also make DNA rather inaccessible."

Multiprotein complexes are able to modify or mobilize histones to overcome the obstacle imposed by histones, and it has long been assumed that such complexes must act in concert with DNA repair enzymes at sites of DNA double-strand breaks. It was unclear, however, which types of histone-modifying complexes do this job, how they target sites of DNA double-strand breaks, or how they remodel histones to assist DNA repair.

The complex acting in this process turned out to be identical to an already identified human complex that contained a number of candidate tumor suppressors including a specialized histone variant called H2A.X/v. H2A.X/v itself becomes phosphorylated by a DNA damage- recognizing factor in the proximity of DNA double-strand breaks. This finding raised the possibility that the complex, which was called the dTip60 complex, might specifically be attracted by phospho-H2A.X/v, and thus targeted to sites of DNA damage.

Dr. Kusch was able to demonstrate that this complex recognizes phospho-H2A.X/v when present on DNA. It then modifies the phospho-histone by acetylating it, which facilitates its removal from DNA.
'"/>

Contact: Marie Jennings
mfj@stowers-institute.org
816-926-4015
Stowers Institute for Medical Research
16-Dec-2004


Page: 1 2

Related biology news :

1. Stowers Institutes Workman Lab demonstrates mechanism for decoding histone modification marks
2. Stowers Institute scientist named Searle Scholar
3. Stowers scientists clarify role of tumor suppressor gene
4. Stowers scientists demonstrate mechanism of vertebral formation
5. Fourth Stowers researcher awarded Basil OConnor Award
6. Stowers researcher answers fundamental question of cell death
7. Stowers Institute scientist named American Cancer Society research professor
8. Innovative tagging technique may help researchers better protect fish stocks
9. Penn researchers discover how key protein stops inflammation
10. ASU researchers partner with UOP to make biofuel for military jets a reality
11. Einstein researchers prototype vaccine could provide improved protection against tuberculosis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/4/2019)... ... June 04, 2019 , ... ... for salient features of seizure risk signals, usually based on variations of amplitude, ... remains the only acceptable diagnostic methodology due to the complexity and variability of ...
(Date:5/31/2019)... ... May 29, 2019 , ... FileWave, ... and mobile, announces the launch of version 13.1. The new version extends FileWave’s ... API, and supports Apple’s spring release functionality. Version 13.1 builds on FileWave’s version ...
(Date:5/31/2019)... ... May 31, 2019 , ... ... Westchase in Houston, TX, announced today that Ben Reiter, Senior Writer at Sports ... of Wednesday, October 3rd.     , Reiter predicted the Houston Astros would win the ...
Breaking Biology News(10 mins):
(Date:5/31/2019)... ... May 30, 2019 , ... ... to demonstrate an efficient delivery system for the sustained release of human placental ... plasma-based gel system was able to deliver CM into the injured kidney, where ...
(Date:5/14/2019)... ... May 13, 2019 , ... Leak Detection Associates (LDA), the ... Biotechnology, Medical Device and Food Packaging Industries’ is excited to announce the go-live ... LDA’s ability to communicate directly with the marketplace; serving as a destination to ...
(Date:5/4/2019)... ... May 03, 2019 , ... ... the Diopsys® ffERG/Photopic Negative Response vision test, a new full field ... it is estimated that 6.3 million Americans will have glaucoma, with black Americans ...
(Date:5/2/2019)... ... May 02, 2019 , ... Boston ... greater Boston area. Gone are the days of painful hair transplant procedures. Boston ... Restoration System is the only robotic intelligent solution to offer a minimally invasive ...
Breaking Biology Technology:
Cached News: