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Stowers researcher publishes DNA double-strand break repair discovery in Science

In a second step, the dTip60 complex removes phospho-H2A.X/v and replaces it with an unmodified form of the histone. Taken together, Dr. Kusch's findings show that the dTip60 complex increases DNA accessibility at sites of damage for optimal DNA repair and at the same time removes the DNA damage-marker phospho-H2A.X/v to signal the cell that this defect has been successfully repaired.

"These findings answer fundamental questions about DNA double-strand break repair," says Robb Krumlauf, Ph.D., Scientific Director of the Stowers Institute. "They may ultimately help to formulate new strategies of cancer therapy. Dr. Kusch's research with Dr. Workman is another example of the ground-breaking work being conducted here at the Stowers Institute."

Dr. Kusch will continue to focus on the dTip60 complex in his future research. In addition to Dr. Workman, he was joined in this project by Stowers colleagues Laurence Florens, Ph.D., Managing Director of Proteomics; Selene Swanson, Research Specialist I; Susan Abmayr, Ph.D., Associate Investigator; Mike Washburn,, Ph.D., Director of the Proteomics Center; and colleagues at Scripps Research Institute and the Wadsworth Center.


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Contact: Marie Jennings
mfj@stowers-institute.org
816-926-4015
Stowers Institute for Medical Research
16-Dec-2004


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