HOME >> BIOLOGY >> NEWS
Stowers scientists clarify role of tumor suppressor gene

Kansas City, Mo. (April 24, 2006) Jiwang Zhang, Ph.D., formerly a Senior Research Associate at the Stowers Institute for Medical Research, and Linheng Li, Ph.D., Associate Investigator, are credited as the first and last authors, respectively, on a paper highlighting several previously unknown functions of phosphatase and tensin homolog (PTEN), an important tumor suppressor gene.

The findings, published on the Nature Web site on April 23, identified an intrinsic pathway involving PTEN that helps control the transitions that stem cells make between the quiescent and active states. The results demonstrate the importance of the intermediate 'activated' state that describes stem cells that are between the extremes of quiescence and rapid cycling. PTEN functions to decide whether to progress further though the cell cycle or return to a quiescent (G0) state. Disrupting PTEN in stem cells results in more active cycling and a loss of the quiescent pool of stems cells that is necessary for long-term stem cell maintenance.

PTEN can be phosphorylated in response to other signals that modulate its function. The Li Lab's work demonstrated distinct populations of hematopoetic stem cells (HSCs) with phosphorylated and unphosphorylated forms of PTEN, suggesting that PTEN phosphorylation may be a 'sensor' that could help integrate external cues with the HSC quiescence/activation switch.

"Although the primary mutation occurs in stem cells, leading to short-term expansion of normal stem cells, this mutation alone is not enough to support unlimited expansion of either normal or cancer stem cells," said Dr. Li. "A secondary mutation is therefore required to empower the leukemia cells resulting from this mutation to undergo unlimited expansion. Exploring the nature of the secondary mutation, together with the primary mutation in PTEN, can help to understand the self-renewal ability of stem cells and perhaps will identify new molecules that can be targeted to
'"/>

Contact: Marie Jennings
mfj@stowers-institute.org
816-926-4015
Stowers Institute for Medical Research
23-Apr-2006


Page: 1 2

Related biology news :

1. Stowers Institutes Workman Lab demonstrates mechanism for decoding histone modification marks
2. Stowers Institute scientist named Searle Scholar
3. Stowers scientists demonstrate mechanism of vertebral formation
4. Fourth Stowers researcher awarded Basil OConnor Award
5. Stowers researcher answers fundamental question of cell death
6. Stowers researcher publishes DNA double-strand break repair discovery in Science
7. Stowers Institute scientist named American Cancer Society research professor
8. UK scientists working to help cut ID theft
9. Smithsonian scientists show differing patterns of rainforest biodiversity
10. Weizmann Institute scientists discover a control mechanism for metastasis
11. Cornell scientists link E. coli bacteria to Crohns disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/19/2019)... , ... November 19, 2019 , ... The inaugural Cell ... Square in New York City. The one-day event will be chaired by Dr Aiman ... leaders in the space. , “We are witnessing significant innovation in cell and ...
(Date:11/14/2019)... ... November 13, 2019 , ... NDA Partners Chairman Carl ... affairs and program management executive with more than 33 years of regulatory and ... firm as an Expert Consultant. , Robert Peterson has extensive experience in ...
(Date:11/12/2019)... MEMPHIS, Tenn. (PRWEB) , ... November 12, 2019 ... ... in contract manufacturing of orthopedic medical devices, today announced the creation of a ... The reality in the Medical Device industry is that the regulatory element to ...
Breaking Biology News(10 mins):
(Date:11/22/2019)... ... 2019 , ... Lajollacooks4u is preparing for another busy holiday season. Not ... of its popular cooking classes and team-building events, but the company has also booked ... have been a favorite for companies of all sizes since 2008. Each event ...
(Date:11/19/2019)... ... November 19, 2019 , ... ... of deep learning infrastructure solutions for Autonomous Vehicle , Medical Imaging, and ... Unit (IPU) systems with the Graphcore Poplar® software stack as part of its ...
(Date:11/12/2019)... , ... November 12, 2019 ... ... enterprise software solutions for biopharmaceutical R&D, today announced that Immatics Biotechnologies ... adopted Genedata Biologics® to streamline their R&D operations related to ...
(Date:11/12/2019)... ... November 12, 2019 , ... Bode ... Director of Forensic Genealogy, Melinde Lutz Byrne, to the organization. Byrne’s team will ... provide investigative leads to law enforcement through proven genealogy and DNA analysis methods. ...
Breaking Biology Technology:
Cached News: