HOME >> BIOLOGY >> NEWS
Stowers scientists clarify role of tumor suppressor gene

Kansas City, Mo. (April 24, 2006) Jiwang Zhang, Ph.D., formerly a Senior Research Associate at the Stowers Institute for Medical Research, and Linheng Li, Ph.D., Associate Investigator, are credited as the first and last authors, respectively, on a paper highlighting several previously unknown functions of phosphatase and tensin homolog (PTEN), an important tumor suppressor gene.

The findings, published on the Nature Web site on April 23, identified an intrinsic pathway involving PTEN that helps control the transitions that stem cells make between the quiescent and active states. The results demonstrate the importance of the intermediate 'activated' state that describes stem cells that are between the extremes of quiescence and rapid cycling. PTEN functions to decide whether to progress further though the cell cycle or return to a quiescent (G0) state. Disrupting PTEN in stem cells results in more active cycling and a loss of the quiescent pool of stems cells that is necessary for long-term stem cell maintenance.

PTEN can be phosphorylated in response to other signals that modulate its function. The Li Lab's work demonstrated distinct populations of hematopoetic stem cells (HSCs) with phosphorylated and unphosphorylated forms of PTEN, suggesting that PTEN phosphorylation may be a 'sensor' that could help integrate external cues with the HSC quiescence/activation switch.

"Although the primary mutation occurs in stem cells, leading to short-term expansion of normal stem cells, this mutation alone is not enough to support unlimited expansion of either normal or cancer stem cells," said Dr. Li. "A secondary mutation is therefore required to empower the leukemia cells resulting from this mutation to undergo unlimited expansion. Exploring the nature of the secondary mutation, together with the primary mutation in PTEN, can help to understand the self-renewal ability of stem cells and perhaps will identify new molecules that can be targeted to
'"/>

Contact: Marie Jennings
mfj@stowers-institute.org
816-926-4015
Stowers Institute for Medical Research
23-Apr-2006


Page: 1 2

Related biology news :

1. Stowers Institutes Workman Lab demonstrates mechanism for decoding histone modification marks
2. Stowers Institute scientist named Searle Scholar
3. Stowers scientists demonstrate mechanism of vertebral formation
4. Fourth Stowers researcher awarded Basil OConnor Award
5. Stowers researcher answers fundamental question of cell death
6. Stowers researcher publishes DNA double-strand break repair discovery in Science
7. Stowers Institute scientist named American Cancer Society research professor
8. UK scientists working to help cut ID theft
9. Smithsonian scientists show differing patterns of rainforest biodiversity
10. Weizmann Institute scientists discover a control mechanism for metastasis
11. Cornell scientists link E. coli bacteria to Crohns disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/1/2019)... ... March 01, 2019 , ... Geneious would like to announce it ... alternative to Vector NTI. , Geneious Prime already has a dedicated importer for ... NTI, so that files will be organised in Geneious in the same way. ...
(Date:2/27/2019)... (PRWEB) , ... February 26, 2019 , ... Circulomics is ... high molecular weight (HMW) DNA for long-read sequencing library preparation. , This kit ... The gentle processing ensures that HMW DNA is not damaged and recovered with high ...
(Date:2/22/2019)... ... February 20, 2019 , ... As technology ... the traditional line between engineering and medical science grows ever thinner. As medical ... medical device industry is making medical practice easier for doctors, more effective for ...
Breaking Biology News(10 mins):
(Date:3/19/2019)... SAN JOSE, Calif. (PRWEB) , ... March 19, ... ... provider of multi-GPU deep learning cloud solutions, today announced it has extended its ... partnerships with several key colocation data centers that are part of the NVIDIA ...
(Date:3/19/2019)... ... March 19, 2019 , ... ... cloud solutions, today announced it has begun offering NVIDIA® DGX-1™ deep learning systems ... utilize DGX-1, designed to provide the highest performance for artificial intelligence and deep ...
(Date:3/14/2019)... (PRWEB) , ... March 14, 2019 , ... ... Annual Conference & Expo, themed “Navigating the Full Spectrum of Case Management,” continues ... June 10-14, 2019. This conference is the only case management industry conference serving ...
(Date:3/12/2019)... (PRWEB) , ... March 11, 2019 , ... ... first hospital system in Colorado, and among the first in the nation, to ... around lab draws, IV placement and overall degree to which staff showed compassion ...
Breaking Biology Technology:
Cached News: