HOME >> BIOLOGY >> NEWS
Strains of laboratory mice more varied than previously thought

CHAPEL HILL A collaborative study by scientists at the University of North Carolina at Chapel Hill and The Jackson Laboratory in Bar Harbor, Maine, has found that the genetic variation in the most widely used strains of laboratory mice is vastly greater than previously thought.

Where previously there were only 140,000 variations in DNA sequence described, it turns out there are 8.3 million.

Moreover, the study found that the pedigrees of the 15 mouse strains studied are not what they were previously assumed to be. It appears they differ from each other to a far greater degree than do the pedigrees between humans and chimpanzees.

The research, published online July 29 in the journal Nature Genetics and slated for the September print issue, could have major implications for the interpretation and design of studies past and future.

Our article reports the first comprehensive analysis of such variation with an emphasis in evolutionary origin of the variation and its implications for biomedical research. We have rejected many long-held assumptions about the origin and relationships among mouse strains. In the light of our results, the conclusions of previous studies and the design of future studies need to be reevaluated, said study co-author Fernando Pardo-Manuel de Villena, Ph.D., associate professor of genetics at UNCs School of Medicine.

Animal models are essential tools in medical research because they allow researchers the opportunity to systematically probe questions within a defined biological system. The mouse is the most popular mammalian model for the study of human disease and normative biology, partly because their genomes are highly conserved. And, since 99 percent of genes in humans have counterparts in the mouse, cloning of a gene in one species often leads to cloning of the corresponding gene in the other.

The genome of the laboratory mouse has been thought to be a mosaic of DNA region
'"/>

Contact: L.H. Lang
llang@med.unc.edu
919-843-9687
University of North Carolina School of Medicine
29-Jul-2007


Page: 1 2 3

Related biology news :

1. Novel laboratory technique nudges genes into activity
2. Some key laboratory breast cancer cell lines are, indeed, good models for the real disease
3. Novel laboratory model reveals clues to how blood starts clotting
4. Living laboratory found on shoreline statues
5. Agreement to increase the flow of ideas from laboratory to clinic
6. Sperm created in the laboratory from embryonic stem cells produce viable progeny
7. European Columbus laboratory for ISS ready for delivery
8. Researchers evolve a complex genetic trait in the laboratory
9. Component in soy products causes reproductive problems in laboratory mice
10. Human embryonic stem cells have the potential to develop into eggs and sperm in the laboratory
11. Gene therapy completely corrects hemophilia in laboratory animals

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Strains laboratory mice more varied than previously thought

(Date:10/18/2014)... referred for evaluation of suspected genetic conditions, whole-exome ... percent, including detection of a number of rare ... according to a study appearing in JAMA ... with the American Society of Human Genetics annual ... coding regions of thousands of genes simultaneously using ...
(Date:10/17/2014)... available in German . ... few drugs. When treating overdoses, doctors are often limited to ... if there is a combination of drugs involved. So what ... swallows his grandmother,s pills? ETH professor Jean-Christophe Leroux from the ... an answer to this question. "The task was to develop ...
(Date:10/16/2014)... they are anything but sustainable: environmental damage to ... becoming increasingly evident. Despite their disadvantages, however, monocultures ... as the sole possibility of achieving higher yields ... Schmid, an ecology professor at the University of ... and forestry. After all, a new study carried ...
Breaking Biology News(10 mins):Whole-exome sequencing shows potential as diagnostic tool 2Emergency aid for overdoses 2Emergency aid for overdoses 3Plant communities produce greater yield than monocultures 2Plant communities produce greater yield than monocultures 3
(Date:10/25/2014)... (PRWEB) October 24, 2014 Today, Nerium ... announced the winners of its “Reflect Your Youth” contest, ... not only seen a difference in their skin since ... a new outlook on life as a result of ... originated as an effort by Nerium International to inspire ...
(Date:10/25/2014)... NEW YORK , Oct. 24, 2014 ... Access Pharmaceuticals, Inc. (ACCP), a biopharmaceutical company advancing ... implemented a 1-for-50 reverse split of its common ... Friday, October 24, 2014. PlasmaTech,s common stock will ... number 72754H109 and temporary ticker symbol "ACCPD". After ...
(Date:10/22/2014)... NEW YORK , Oct. 22, 2014 ... growth in the in vitro diagnostic (IVD) test industry, ... Kalorama Information. The healthcare market researcher listed more than 25 ... that could be the future of IVD products. Kalorama details ... industry, The Worldwide Market for In Vitro Diagnostic ...
(Date:10/22/2014)... Shimadzu Scientific Instruments introduces its Open ... the pain management and clinical markets. The software increases ... by allowing users to highlight and review results that ... allows analysts to filter results by group or based ... eliminating the need to sift through analytes of no ...
Breaking Biology Technology:Nerium International™ Inspires Conversation About the Journey of Aging with “Reflect Your Youth” Contest 2PlasmaTech Biopharmaceuticals, Inc. Announces Reverse Stock Split, Ticker Change and Launches New Corporate Website 2Report: Radical New IVD Test Approaches Key To Growth 2Report: Radical New IVD Test Approaches Key To Growth 3Shimadzu Releases QuantAnalytics Open Access LCMS Software Package for Clinical Applications 2
Cached News: