HOME >> BIOLOGY >> NEWS
Strains of laboratory mice more varied than previously thought

CHAPEL HILL A collaborative study by scientists at the University of North Carolina at Chapel Hill and The Jackson Laboratory in Bar Harbor, Maine, has found that the genetic variation in the most widely used strains of laboratory mice is vastly greater than previously thought.

Where previously there were only 140,000 variations in DNA sequence described, it turns out there are 8.3 million.

Moreover, the study found that the pedigrees of the 15 mouse strains studied are not what they were previously assumed to be. It appears they differ from each other to a far greater degree than do the pedigrees between humans and chimpanzees.

The research, published online July 29 in the journal Nature Genetics and slated for the September print issue, could have major implications for the interpretation and design of studies past and future.

Our article reports the first comprehensive analysis of such variation with an emphasis in evolutionary origin of the variation and its implications for biomedical research. We have rejected many long-held assumptions about the origin and relationships among mouse strains. In the light of our results, the conclusions of previous studies and the design of future studies need to be reevaluated, said study co-author Fernando Pardo-Manuel de Villena, Ph.D., associate professor of genetics at UNCs School of Medicine.

Animal models are essential tools in medical research because they allow researchers the opportunity to systematically probe questions within a defined biological system. The mouse is the most popular mammalian model for the study of human disease and normative biology, partly because their genomes are highly conserved. And, since 99 percent of genes in humans have counterparts in the mouse, cloning of a gene in one species often leads to cloning of the corresponding gene in the other.

The genome of the laboratory mouse has been thought to be a mosaic of DNA region
'"/>

Contact: L.H. Lang
llang@med.unc.edu
919-843-9687
University of North Carolina School of Medicine
29-Jul-2007


Page: 1 2 3

Related biology news :

1. Novel laboratory technique nudges genes into activity
2. Some key laboratory breast cancer cell lines are, indeed, good models for the real disease
3. Novel laboratory model reveals clues to how blood starts clotting
4. Living laboratory found on shoreline statues
5. Agreement to increase the flow of ideas from laboratory to clinic
6. Sperm created in the laboratory from embryonic stem cells produce viable progeny
7. European Columbus laboratory for ISS ready for delivery
8. Researchers evolve a complex genetic trait in the laboratory
9. Component in soy products causes reproductive problems in laboratory mice
10. Human embryonic stem cells have the potential to develop into eggs and sperm in the laboratory
11. Gene therapy completely corrects hemophilia in laboratory animals

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/12/2016)... -- WearablesResearch.com , a brand of Troubadour Research ... the Q1 wave of its quarterly wearables survey. A ... to a program where they would receive discounts for ... "We were surprised to see that so ... , CEO of Troubadour Research, "primarily because there are ...
(Date:4/28/2016)... and BANGALORE, India , April 28, 2016 ... a product subsidiary of Infosys (NYSE: INFY ), ... a global partnership that will provide end customers ... mobile banking and payment services.      (Logo: ... innovation area for financial services, but it also plays a ...
(Date:4/26/2016)... 27, 2016 Research and ... Biometrics Market 2016-2020"  report to their offering.  , ... The analysts forecast the global multimodal biometrics ... during the period 2016-2020.  Multimodal biometrics ... such as the healthcare, BFSI, transportation, automotive, and ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... ... Plate® YM (Yeast and Mold) microbial test has received AOAC Research Institute approval ... of microbial tests introduced last year,” stated Bob Salter, Vice President of Regulatory ...
(Date:6/23/2016)... June 23, 2016   EpiBiome , a precision ... million in debt financing from Silicon Valley Bank (SVB). ... and to advance its drug development efforts, as well ... "SVB has been an incredible strategic partner ... a traditional bank would provide," said Dr. Aeron ...
(Date:6/23/2016)... ... June 23, 2016 , ... In a new case report published today ... a patient who developed lymphedema after being treated for breast cancer benefitted from an ... paradigm for dealing with this debilitating, frequent side effect of cancer treatment. ...
(Date:6/23/2016)... , June 23, 2016 ... Hematology Review, 2016;12(1):22-8 http://doi.org/10.17925/OHR.2016.12.01.22 ... , the peer-reviewed journal from touchONCOLOGY, Andrew ... escalating cost of cancer care is placing an ... result of expensive biologic therapies. With the patents ...
Breaking Biology Technology:
Cached News: