HOME >> BIOLOGY >> NEWS
Stress hormones may play new role in speeding up cancer growth

COLUMBUS , Ohio -- New research here suggests that hormones produced as during periods of stress may increase the growth rate of a particularly nasty kind of cancer.

The study showed that an increase in norepinephrine, a stress hormone, can stimulate tumor cells to produce two compounds. These compounds can break down of the tissue around the tumor cells and allow the cells to more easily move into the bloodstream. From there, they can travel to another location in the body to form additional tumors, a process called metastasis.

The research also suggests the same hormone can also stimulate the tumor cells to release another compound that can aid in the growth of new blood vessels that feed cancer cells, hastening the growth and spread of the disease. The work was reported in the latest issue of the journal Cancer Research.

"This opens up an entirely new way of looking at stress and cancer that's different from current interpretations," explained Ronald Glaser, a professor of molecular virology, immunology and medical genetics, and director of the Institute for Behavioral Medicine Research at Ohio State University .

Glaser and Eric Yang, a research scientist in the same institute, focused on the role of these three compounds. Two of them, both matrix metalloproteinases -- MMP-2 and MMP-9 -- play a role in breaking down the scaffolding that cells attach to in order to maintain their shape. The third compound, vascular endothelial growth factor (VEGF), is important in the growth of new blood vessels into tumor cells.

Earlier work by researcher Anil Sood at the University of Texas had shown that the same stress hormones can stimulate ovarian tumor cells to produce these three compounds. The key to that discovery was that the two stress hormones epinephrine and norepinephrine would bind to places on the surface of ovarian cancer cells, called adrenergic receptors, and stimulate the release OF MMP-2, MMP-9 and VEGF w
'"/>

Contact: Ronald Glaser
Glaser.1@osu.edu
614-292-5526
Ohio State University
1-Nov-2006


Page: 1 2 3

Related biology news :

1. Stressed-out African naked mole-rats may provide clues about human infertility
2. Stress and nerve cells survival in rats; finding may open window for depression treatment
3. Stress and the city: Urban birds keep cool
4. Stress imaging tests predict prognosis of heart disease in obese persons
5. Stress-induced levels of corticotropin-releasing factor responsible for binge behaviour
6. Stress interferes with problem-solving; Beta-blocker may help
7. Stressed cells spark DNA repair missteps and speed evolution
8. Stress, mood and other factors may affect moms diet during pregnancy
9. Stress impairs thinking via mania-linked enzyme
10. Role of thyroid hormones in slumber under investigation at Rutgers
11. Steroid hormones regulate the body clock

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/11/2019)... ... July 11, 2019 , ... ... first on-site Legionella DNA test, today announced a partnership with LiquiTech, a ... , Through this strategic partnership, LiquiTech will integrate Spartan’s innovative environmental DNA ...
(Date:7/5/2019)... VIEW, Calif. (PRWEB) , ... July 05, 2019 ... ... partnering with Microsoft to bring its patented Tractus™ Platform to governments around the ... will bring cutting edge technology and point of care solutions to operating theatres ...
(Date:6/19/2019)... (PRWEB) , ... June 19, 2019 , ... Dahryn Trivedi, ... physicochemical properties of Cefazolin Sodium, antibiotic which can prove to be beneficial for treating ... 519% increase in residue amount , Over 68% decrease in weight ...
Breaking Biology News(10 mins):
(Date:6/11/2019)... ... June 10, 2019 , ... Advancements ... an upcoming episode, scheduled to broadcast 4Q/2019. Check your local listings for more ... educate viewers about how its technology facilitates laboratories to improve efficiency and quality ...
(Date:6/11/2019)... ... June 11, 2019 , ... A study ... stem cells (MSC-EV) are able to incorporate into human CD34+ cells, modifying their ... mice, MSC-EVs also increased the cells’ ability to lodge into bone marrow. This ...
(Date:5/31/2019)... ... May 30, 2019 , ... World ... Integrity on July 08-09, 2019 in Boston, MA. This peer recommended interactive workshop ... organizations. , The training will kick off with a compendial treatment of Data ...
(Date:5/21/2019)... (PRWEB) , ... May 21, 2019 , ... ... in Berlin (VLB) today officially opened the inaugural Africa Brewing Conference dedicated to ... malting industry in Africa. The event, which is supported through a partnership with ...
Breaking Biology Technology:
Cached News: