HOME >> BIOLOGY >> NEWS
Structure determined for p53 tumor suppressor protein as bound to DNA for anti-cancer activity

(Philadelphia July 17, 2006) - More than half of human cancers involve mutations in the p53 tumor-suppressor gene, suggesting the critical role played by the normal p53 protein in defending against cancer. Similarly, roughly 95 percent of cancer-causing mutations in the p53 protein occur in its DNA-binding core domain, pointing to this region of the p53 protein as being pivotal to its anti-cancer activity.

Clearly, a detailed view of the p53 protein in direct contact with DNA could provide important insights into preventing and treating an array of human cancers. To date, however, despite having learned a good deal about the protein's biochemistry over the years, scientists have been unable to "see" the protein using the tools of structural biology bound to DNA in its naturally occurring form. This naturally occurring form contains a pairing of two p53 proteins, called a dimer, that then binds to a second p53 dimer in a similar way to create the precisely oriented four-protein complex, called a tetramer, that binds DNA.

Now, in a new study featured as a "paper of the week" and on the cover of the July 21 issue of the Journal of Biological Chemistry, researchers at The Wistar Institute have successfully determined the three-dimensional structure of the p53 protein bound as a dimer to DNA and used the structure to produce an accurate model of the p53 tetramer bound to DNA.

"The bottom line is that we now have a detailed picture of how p53 binds DNA," says Ronen Marmorstein, Ph.D., a professor in the Gene Expression and Regulation Program at Wistar and senior author on the study. "Given the fact that p53 is an important tumor suppressor that is mutated in the majority of human cancers, this will undoubtedly be useful information."

Earlier work had shown how p53 binds to DNA as a stand-alone entity, a form that does not represent the natural state of p53 binding to DNA. The present work captures p53 bound to DNA in its natur
'"/>

Contact: Franklin Hoke
hoke@wistar.org
215-898-3716
The Wistar Institute
17-Jul-2006


Page: 1 2

Related biology news :

1. International Conference on Modern Bamboo Structures Oct. 11-17
2. Structure of iron regulatory protein-RNA complex solved
3. Self-assembling nano-ice discovered at UNL -- Structure resembles DNA
4. Structure of enzyme offers treatment clues for diabetes, Alzheimers
5. Structure determined for key molecular complex involved in long-term gene storage
6. Structure of key enzyme in plague bacterium found
7. Structures of marine toxins provide insight into their effectiveness as cancer drugs
8. Breakthrough: Structure of membrane protein described by Hebrew University, German researchers
9. Structure-building cell signals also may influence learning, memory
10. Structure of new DNA enzyme family member found
11. Left-right wiring determined by neural communication in the embryonic worm

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/12/2019)... ... November 12, 2019 , ... Atlantic Ultraviolet Corporation (AUV), the ... distributors voted their patented automatic and manual wipers the #1 best feature of ... frequent maintenance task required of an ultraviolet water purifier is quartz sleeve cleaning. ...
(Date:11/6/2019)... ... November 06, 2019 , ... ... MD, a senior pharmaceutical industry executive with expertise in clinical pharmacology and pharmacometrics ... and disease strategic data analytics, has joined the firm as an Expert Consultant. ...
(Date:11/2/2019)... ... 31, 2019 , ... In this podcast, Smith spoke about the history of ... consulting. , The Beyond the Lab Podcast is an interview series initiated by Vanderbilt ... jobs in the biomedical field — and in these interviews, the alumni discuss the ...
Breaking Biology News(10 mins):
(Date:11/2/2019)... ... October 31, 2019 , ... drug360 graph, a ... tellic. drug360 brings tellic’s expertise in biomedical language processing and machine learning ... uncover relationships between genes, diseases, variants, phenotypes, and other biomedical entities. Researchers ...
(Date:10/29/2019)... ... October 29, 2019 , ... Modality ... Silver sponsorship and cold chain validation workshop at the Biomanufacturing World Summit (BMWS19) ... Diego, California. , The Biomanufacturing World Summit brings together pharmaceutical executives, ...
(Date:10/22/2019)... ... 2019 , ... Catalent, a global leader in clinical supply services, today announced ... participate in a panel session titled “Cell and Gene Therapy Logistics” at the upcoming ... Chicago, on Oct. 28-30, 2019. , The panel session, on Wednesday, Oct. 30 at ...
(Date:10/17/2019)... Conn. (PRWEB) , ... October 16, 2019 , ... ... that provides personalized, easy-to-understand, web-based genetic counseling information, has published a new white ... five year period and provides guidance as to how patients and medical providers ...
Breaking Biology Technology:
Cached News: