HOME >> BIOLOGY >> NEWS
Structure of iron regulatory protein-RNA complex solved

The surprising structure and properties of a protein responsible for regulating the transport, storage and use of iron -- as it binds its target RNA -- are described by researchers from the University of Illinois at Chicago in the Dec. 22 issue of Science.

Iron is an essential nutrient, and defects in uptake and metabolism that result in either deficiencies or overload of iron cause a variety of diseases and disorders, including heart disease, arthritis and cancer.

The iron regulating protein, called IRP1, has two structural forms, each with important functions within the cell.

When serving as one of two regulators of cellular iron metabolism through its control of gene expression, the tightly coiled IRP1 opens up to expose sites that bind messenger RNA at sites on the RNA called iron responsive elements, or IREs, that are common in genes involved in iron metabolism.

In its alternate form, IRP1 binds a cluster of iron and sulfur atoms to act as an important metabolic enzyme called aconitase. The assembly and disassembly of the iron/sulfur cluster in the aconitase form appears to be an effective mechanism for regulating IRP1 activity.

"We found that when IRP1 releases the iron/sulfur cluster and opens up to bind RNA, it undergoes an extraordinary, unexpected rearrangement," said William Walden, professor of microbiology and immunology at UIC and lead author of the study.

"This is the crucial step in understanding the specialized cellular processes that have evolved to maintain internal iron concentrations at the appropriate safe and useful levels and is important to the future design of therapeutic targets," Walden said.

IRP1 is a very large protein, composed of about 900 amino acids arranged into four major domains.

"We expected that IRP1 would open up the two major domains facing each other along a hinge, rather like a clam shell, to accommodate the RNA binding," Walden said. "What
'"/>

Contact: Jeanne Galatzer-Levy
jgala@uic.edu
312-996-1583
University of Illinois at Chicago
21-Dec-2006


Page: 1 2

Related biology news :

1. International Conference on Modern Bamboo Structures Oct. 11-17
2. Self-assembling nano-ice discovered at UNL -- Structure resembles DNA
3. Structure of enzyme offers treatment clues for diabetes, Alzheimers
4. Structure determined for key molecular complex involved in long-term gene storage
5. Structure of key enzyme in plague bacterium found
6. Structure determined for p53 tumor suppressor protein as bound to DNA for anti-cancer activity
7. Structures of marine toxins provide insight into their effectiveness as cancer drugs
8. Breakthrough: Structure of membrane protein described by Hebrew University, German researchers
9. Structure-building cell signals also may influence learning, memory
10. Structure of new DNA enzyme family member found
11. Master regulatory gene of epithelial stem cells identified

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/14/2019)... LAKE CITY, and MARTINSRIED, Germany (PRWEB) , ... ... ... in high-throughput antibody screening and characterization, announced today that they have opened a ... Carterra’s platform has fueled the need for the new office. , The Munich ...
(Date:8/14/2019)... JOLLA, Calif. (PRWEB) , ... August 14, 2019 , ... ... insight into their future children, announces inclusion in the 38th annual Inc. 500|5000 ... been eligible to apply. To qualify, companies must have been founded and generating revenue ...
(Date:8/9/2019)... ... August 09, 2019 , ... With a demand in healthcare to ... patients will visit urgent care centers (UCC) in the coming years, according to a ... The Market for Urgent Care Centers , is a detailed look at the current ...
Breaking Biology News(10 mins):
(Date:8/27/2019)... ... August 27, 2019 , ... Modality Solutions , an ... promoted Consulting Engineer, Robert Battista, to Senior Consulting engineer. , In his new ... mentoring new engineers as well as the creation of additional business opportunities and ...
(Date:8/15/2019)... ... , ... PathSensors announced today that Roger Lawrence has joined ... of Food Technologists (IFT) Board of Directors, Illinois Institute of Technology (IIT) Institute ... and Applied Nutrition (JIFSAN) Advisory Council and the University of Maryland College of ...
(Date:8/7/2019)... (PRWEB) , ... August 07, 2019 , ... Locus Agricultural ... breakthrough line of soil amendments (soil “probiotics”), including Rhizolizer ® , which is ... year—the largest impact any approach has offered to date. Results from the treatment of ...
(Date:8/6/2019)... ... August 06, 2019 , ... The National Science Foundation (NSF) ... community project that will engage middle and early high school students in environmental ... Citizen Science Network for Community Environmental Assessment.” Collaborative partners presenting the authentic science ...
Breaking Biology Technology:
Cached News: