HOME >> BIOLOGY >> NEWS
Stuck on you: CEACAM6 helps E. coli stick to intestinal lining in Crohn's disease

In Crohn's disease, the lining of the small intestine is abnormally colonized by E. coli organisms that are able to adhere to and invade intestinal epithelial cells. In a study appearing online on May 24 in advance of publication in the June print issue of the Journal of Clinical Investigation, Arlette Darfeuille-Michaud and colleagues from Universit d'Auvergne, France, show that the adherent-invasive E. coli (AIEC) adhere to a region of intestinal epithelial cells known as the brush border in patients with Crohn's disease, but not in healthy individuals. They show that this adhesion is dependent on the expression of the receptor CEACAM6 (carcinoembryonic antigenrelated cell adhesion molecule 6) on the surface of the epithelial cells. They go on to show that CEACAM6 expression is increased in Crohn's disease patients after infection with AIEC bacteria, indicating that this organism can promote its own colonization in individuals with Crohn's disease. The authors conclude that CEACAM6 expression in individuals with inflammatory bowel disease could be used as a diagnostic marker for Crohn's disease.


'"/>

Contact: Brooke Grindlinger
press_releases@the-jci.org
212-342-9006
Journal of Clinical Investigation
24-May-2007


Page: 1

Related biology news :

1. Genetic variation helps to understand predisposition to schizophrenia
2. Link between sunspots, rain helps predict disease in east Africa
3. Taking a supplement of glycine helps prevent degenerative diseases such as arthrosis or osteoporosis
4. Progesterone therapy and preterm birth: More evidence helps identify women who can benefit
5. Nanotechnology helps scientists make bendy sensors for hydrogen vehicles
6. Preconditioning helps protect brains blood vessels from stroke
7. Manchester University helps with pharaoh DNA analysis
8. A spoonful of sugar helps your waistline go down
9. Study helps preserve Arctic whale, Eskimo subsistence hunt
10. Ethanol injection helps manage bone metastasis in thyroid cancer patients
11. Fusing imaging technologies creates synergy, helps diagnose heart disease accurately

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Stuck you CEACAM6 helps coli stick intestinal lining Crohn disease

(Date:10/29/2014)... bodies decompose, their types and numbers of bugs ... could mean the difference between a closed case ... is using a more than $866,000 U.S. Department ... examine these changing populations. The microbial communities may ... death, gender, race, socioeconomic relations and more, said ...
(Date:10/29/2014)... new research potential of the Barcode of Life ... the Biodiversity Data Journal (BDJ) ... and imported these into a human-readable text developed in ... Data were used to study the species distributions of ... subfamily. , BOLD is originally designed to support the ...
(Date:10/29/2014)... is a hormone released by the stomach and it ... as a psychoactive substance that primarily affects brain function, ... , This knowledge, combined with findings from animal studies, ... potential to stimulate alcohol craving. , Dr. Lorenzo Leggio ... that, as they had anticipated, alcohol craving was increased ...
Breaking Biology News(10 mins):MSU partners with Detroit to investigate death scenes 2Go straight and publish: From Barcode of Life Data Systems to scholarly publishing systems 2Ghrelin stimulates an appetite for drinking alcohol 2
(Date:10/30/2014)... 2014 A new report, commissioned by BioCrossroads ... an in-depth look at Indiana,s ... over two different time frames: 1993 to 2002 and ... future opportunities for investment growth.  The Life Science ... report shows gains in innovation dollars as well as an ...
(Date:10/30/2014)... 29, 2014) – The severe flooding that devastated a ... less destructive if the bridges, roads and other infrastructure ... study from the University of Colorado Denver. , "People ... said Jimmy Kim, PhD, associate professor of structural engineering ... Science and lead author the study. "There is an ...
(Date:10/27/2014)... , October 27, 2014 ... right to produce, exhibit and sell its artificial ... to impeach their patent.      (Photo: ... four years of fighting, the definitive judgement has ... and produces innovative and accessible hi-tech prostheses with ...
(Date:10/27/2014)... October 27, 2014 The “Molecular ... Genetics, Microbiology), Technology (PCR, INAAT, DNA Sequencing), End ... Service, Software) - Global Forecast to 2018” provides ... challenges, opportunities, current market trends, and strategies impacting ... estimates and forecasts of the revenue and share ...
Breaking Biology Technology:New report shows Indiana's gains in life sciences innovation capital outpace the nation 2New report shows Indiana's gains in life sciences innovation capital outpace the nation 3New report shows Indiana's gains in life sciences innovation capital outpace the nation 4New report shows Indiana's gains in life sciences innovation capital outpace the nation 5CU Denver study says upgrading infrastructure could reduce flood damage 2Italian Lower Limb Prosthesis Company Wins Lawsuit Against German Giant Ottobock 2Global Molecular Diagnostics Market Will Reach $7.9 Billion by 2018 - New Research Report by MarketsandMarkets 2Global Molecular Diagnostics Market Will Reach $7.9 Billion by 2018 - New Research Report by MarketsandMarkets 3Global Molecular Diagnostics Market Will Reach $7.9 Billion by 2018 - New Research Report by MarketsandMarkets 4Global Molecular Diagnostics Market Will Reach $7.9 Billion by 2018 - New Research Report by MarketsandMarkets 5
Cached News: