HOME >> BIOLOGY >> NEWS
Studies assess effectiveness of serotonin and nerve stimulants on irritable bowel syndromes

hnical University of Munich and the Ludwig Maximillian University of Munich in Germany investigated whether EC cells in the intestine express nasal olfactory receptors (ORs, receptors used for smelling) to determine whether odorants present in spices, fragrances, cigarettes, detergents and cosmetics may cause serotonin release, thereby provoking a GI response.

To evaluate this connection, researchers studied human EC cells isolated from mucosal biopsies by laser microdissection and an EC derived cell line. The experiments revealed expression of several ORs in the isolated EC cells, as well as the cell line. Using digital fluorescence imaging, the team found that activation of the cells with odorants caused elevation of intracellular Ca2+, followed by serotonin release up to 10-fold that of the controls. Odorants like thymol (thyme), eugenol (cloves), bourgeonal (floral, lily-of-the-valley), helional (brown algae) and substances present in roses, bananas or raspberries, specifically, caused an elevation of Ca2+ levels.

The findings suggest that these types of odorants may cause a serotonin-related GI reaction. The effects could be inhibited by known OR antagonists, such as methyl isoeugenol (a competitive antagonist of eugenol) or by blocking Ca2+ influx (e.g., via Ca2+ channels with nifedipine, a drug used in the treatment of hypertension because it relaxes blood vessels).

"Our results show that odorants present in the gut may stimulate serotonin release via olfactory receptors expressed in human enterochromaffin cells in the gut mucosa," said Petra Voland, Ph.D., of the Technical University of Munich, and one of the lead investigators of the study. "Serotonin controls peristalsis and is implicated in pathological conditions such as vomiting, diarrhea and irritable bowel syndrome. Thus, olfactory receptors are potential novel targets for the treatment of gastrointestinal diseases and motility disorders."

Dr. Voland w
'"/>

Contact: Aimee Frank
AFrank@gastro.org
301-941-2620
American Gastroenterological Association
21-May-2007


Page: 1 2 3 4

Related biology news :

1. Studies to find better ways to preserve human eggs, ovarian tissue under way
2. The Institute of Ecosystem Studies recognized by the Wildlife Society
3. The Institute of Ecosystem Studies to host an international conference on ecology and urban design
4. Hot flashes -- Studies explore the role of genes, obesity and alcohol
5. Studies force new view on biology of flavonoids
6. Studies of population genetics, evolution are an exercise in bad taste
7. Studies identify DNA regions linked to nicotine dependence
8. Studies at cancer conference show new therapies changing outlook for blood cancer patients
9. Studies find general mechanism of cellular aging
10. Institute of Ecosystem Studies director and scientist honored by the Botanical Society of America
11. Studies show that rockfish thrive with offshore platforms as their home base

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/2/2020)... (PRWEB) , ... March 02, 2020 , ... ... at the 71st annual Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy ( ... Chicago, Illinois. Pittcon is the world’s leading annual conference and exposition on laboratory ...
(Date:2/28/2020)... ... February 27, 2020 , ... An ... innovative treatment solutions for maladies, such as Inflammatory Bowel Disease (IBD), specifically Crohn’s ... segment will focus on a novel platform developed by Deka Biosciences, Inc. (Deka ...
(Date:2/28/2020)... ... February 28, 2020 , ... Regen Suppliers is now ... all available stem cell and exosome biologics. , Regen Suppliers offers an extensive ... kits, adipose kits, PDO thread lifts and more. The company is truly ...
Breaking Biology News(10 mins):
(Date:3/12/2020)... ... March 12, 2020 , ... ... force microscopy (AFM) technology, increases the business investment in Europe by inaugurating a ... The Grand Opening Ceremony of the new Nanoscience Center Europe took place Tuesday, ...
(Date:3/4/2020)... WASHINGTON (PRWEB) , ... March 04, 2020 , ... This ... Exhibition in Orlando, FL. The company will showcase both expanded and emerging offerings that ... HIMSS 2020 is designed to be comprehensive, timely, and engaging. From ...
(Date:2/26/2020)... , ... February 25, 2020 , ... ... & Biosciences (DuPont) recently published the results of its safety assessment on the ... HMOs currently identified in human milk. These complex carbohydrates are indigestible and therefore ...
(Date:2/21/2020)... ... February 21, 2020 , ... Pharmaceutical manufacturers are under ... to adapt to new approaches like ‘Industry 4.0’ and continuous manufacturing, combat the ... medicine and therapies. But with an industry with the world’s tightest regulations and ...
Breaking Biology Technology:
Cached News: