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Studies assess effectiveness of serotonin and nerve stimulants on irritable bowel syndromes

s decreased from 17.6 to 9.3 minutes, straining decreased from 4.4 to 2.9 episodes per week, abdominal pain decreased from 4.4 to 2.0 days per week, and perception of incomplete evacuation decreased significantly.

In evaluating the results of the various assessment tools set forth at the start of the trial, researchers found that: the CCCS (0=no constipation, 30=severe constipation) decreased from 18.0 to 10.2; mean VAS (0=severe symptoms, 100=no symptoms) increased from 18 to 66; and SF-36 subsets of physical functioning, general health, vitality, social functioning and mental health significantly improved.

"While constipation is rarely life-threatening, associated symptoms of abdominal pain, bloating and the sensation of incomplete evacuation can severely affect the physical and emotional well-being of patients. There are many treatment options for the condition and the best approach relies on a clear understanding of the underlying cause," said Thomas Dudding, M.D., of St. Mark's Hospital in London, England, and lead investigator for the study. "This study found that sacral nerve stimulation is an effective treatment for idiopathic constipation that is resistant to conservative treatment. As a result of this stimulation process, improvement occurs in bowel frequency, associated symptoms and overall quality of life."

Dr. Dudding will present this study on Sunday, May 20, at 2:15 p.m. in Room 151A.


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Contact: Aimee Frank
AFrank@gastro.org
301-941-2620
American Gastroenterological Association
21-May-2007


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