HOME >> BIOLOGY >> NEWS
Studies find general mechanism of cellular aging

CHAPEL HILL -- Three separate studies confirm a gene that suppresses tumor cell growth also plays a key role in aging. The researchers found increasing concentration, or expression, of the gene p16INK4a in older cells; these aging cells worked poorly compared to young cells and remembered their "age" even when transferred from old mice to young mice. The cells of mice bred without the gene showed less sluggishness as the animals aged and continued to function in a manner more similar to cells from younger mice.

Teams from the medical schools at the University of North Carolina at Chapel Hill, University of Michigan and Harvard University observed similar results in pancreatic islet cells and brain and blood stem cells.

The results show disparate cell types share a common aging mechanism and suggest that aging-related diseases such as diabetes result from a failure of cell growth, said Dr. Norman E. Sharpless, co-author on the three studies and an assistant professor of medicine and genetics at the UNC School of Medicine. "The studies indicate that certain stem cells lose their ability to divide and replace themselves with age as the expression of p16INK4a increases," said Sharpless, a member of the UNC Lineberger Comprehensive Cancer Center.

The trio of reports are published online Sept. 6 in the journal Nature. The three research teams are from the medical schools at UNC, the University of Michigan and Harvard University.

The UNC study focused on p16INK4a effects on the function of pancreatic islet cells. Islet cells are responsible for insulin production and secretion. Because p16INK4a stops cancer cells from dividing and demonstrates increased expression with age, the scientists suspected the gene played a similar role in aging. The researchers developed strains of mice that were either deficient in p16INK4a (the gene was deleted, or 'knocked out") or genetically altered to have an excess of the protein to a degree seen in aging. <
'"/>

Contact: L.H. Lang
llang@med.unc.edu
919-843-9687
University of North Carolina School of Medicine
6-Sep-2006


Page: 1 2 3

Related biology news :

1. Studies to find better ways to preserve human eggs, ovarian tissue under way
2. Studies assess effectiveness of serotonin and nerve stimulants on irritable bowel syndromes
3. The Institute of Ecosystem Studies recognized by the Wildlife Society
4. The Institute of Ecosystem Studies to host an international conference on ecology and urban design
5. Hot flashes -- Studies explore the role of genes, obesity and alcohol
6. Studies force new view on biology of flavonoids
7. Studies of population genetics, evolution are an exercise in bad taste
8. Studies identify DNA regions linked to nicotine dependence
9. Studies at cancer conference show new therapies changing outlook for blood cancer patients
10. Institute of Ecosystem Studies director and scientist honored by the Botanical Society of America
11. Studies show that rockfish thrive with offshore platforms as their home base

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/12/2019)... ... 2019 , ... G5, the leader in real estate marketing ... 25% and reduces cost-per-click by as much as 15%. An integral part of ... predict best advertising outcomes and automatically allocate daily ad investments across the campaigns, ...
(Date:11/12/2019)... N.Y. (PRWEB) , ... November 12, 2019 , ... ... germicidal ultraviolet air and water purifiers, announced today that distributors voted their patented ... and MEGATRON ® water purifiers. , The most frequent maintenance task required ...
(Date:11/9/2019)... ... 08, 2019 , ... SiteSeer Technologies, creator of SiteSeer Professional retail site selection ... user of SiteSeer. The boutique real estate developer of single and multi-tenant buildings on ... supplement its own analysis of markets. , Geoffrey Kerth, manager of GPK Acquisitions, ...
Breaking Biology News(10 mins):
(Date:11/5/2019)... POWAY, Calif. (PRWEB) , ... November 05, 2019 , ... Ole, a German Shepherd, was ... difficulty with stairs and jumping. Though his energy level and his willingness to play ... to veterinary surgeon Dr. Holly Mullen of VCA Emergency Animal Hospital and Referral Center ...
(Date:10/30/2019)... ... October 30, 2019 , ... Western University of ... innovation and technology play in educating the next generation of health care providers. ... and presentations by WesternU administrators and representatives of companies working with the University ...
(Date:10/22/2019)... ... 2019 , ... nQ Medical, Inc. of Cambridge, MA, was recognized in the ... was announced at a showcase event yesterday in Los Angeles. nQ competed against 3,500 ... and impressive near-term growth projections to be named one of the most fundable companies ...
(Date:10/17/2019)... ... October 16, 2019 , ... ... easy-to-understand, web-based genetic counseling information, has published a new white paper that explores ... and provides guidance as to how patients and medical providers can be kept ...
Breaking Biology Technology:
Cached News: