HOME >> BIOLOGY >> NEWS
Studies reveal methods viruses use to sidestep immune system

DALLAS Feb. 14, 2005 A series of studies by researchers at UT Southwestern Medical Center sheds light on the mechanisms used by viruses to thwart a host's immune defenses and may aid in the development of more effective drugs to fight hepatitis C and West Nile viruses, as well as the flu and the common cold.

In a study to appear in a March issue of the Journal of Virology and currently available online, UT Southwestern researchers describe how an essential gene, called RIG-I, turns on a cascade of host immune defenses when the hepatitis C virus (HCV) replicates in cultured human cells.

Those immune defenses should fight off the virus, but in a separate study, scheduled to appear online this week and in an upcoming issue of the Proceedings of the National Academy of Sciences, the researchers show how HCV sidesteps the immune response, allowing the virus to replicate unchecked.

Dr. Michael Gale, associate professor of microbiology at UT Southwestern and senior author of the two studies, said the tactics employed by HCV to infect a host are likely to be similar to those employed by other RNA viruses such as West Nile, influenza and the common cold.

"This work has broad implications that go beyond just the hepatitis C virus, and that's what we're most excited about," said Dr. Gale. "It's a battle between viruses and humans. Viruses have co-evolved with their hosts, so every time we have evolved a gene with a new function that allows us to fight off a virus, the virus adapts and comes up with a new function of its own to counteract our defenses."

Further defining how RNA viruses target and control host immune defenses will aid in drug development to combat disease, he said.

In the Virology paper, Dr. Gale and his research group found that a specific mutation in the gene RIG-I conferred permissiveness to HCV, allowing it to replicate "like gangbusters" in those cells with the mutation, Dr. Gale said. He and his group determined that
'"/>

Contact: Amanda Siegfried
amanda.siegfried@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
14-Feb-2005


Page: 1 2 3

Related biology news :

1. Studies to find better ways to preserve human eggs, ovarian tissue under way
2. Studies assess effectiveness of serotonin and nerve stimulants on irritable bowel syndromes
3. The Institute of Ecosystem Studies recognized by the Wildlife Society
4. The Institute of Ecosystem Studies to host an international conference on ecology and urban design
5. Hot flashes -- Studies explore the role of genes, obesity and alcohol
6. Studies force new view on biology of flavonoids
7. Studies of population genetics, evolution are an exercise in bad taste
8. Studies identify DNA regions linked to nicotine dependence
9. Studies at cancer conference show new therapies changing outlook for blood cancer patients
10. Studies find general mechanism of cellular aging
11. Institute of Ecosystem Studies director and scientist honored by the Botanical Society of America

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/21/2016)... VANCOUVER, British Columbia , June 21, 2016 ... been appointed to the new role of principal ... has been named the director of customer development. ... , NuData,s chief technical officer. The moves reflect ... development teams in response to high customer demand ...
(Date:6/15/2016)... , June 15, 2016 ... report titled "Gesture Recognition Market by Application Market - Global Industry ... - 2024". According to the report, the  global gesture ... in 2015 and is estimated to grow at ... billion by 2024.  Increasing application of ...
(Date:6/7/2016)... TORONTO , June 7, 2016  Syngrafii ... begun a business relationship that includes integrating Syngrafii,s ... pilot branch project. This collaboration will result in ... for the credit union, while maintaining existing document ... http://photos.prnewswire.com/prnh/20160606/375871LOGO ...
Breaking Biology News(10 mins):
(Date:12/2/2016)... ... 02, 2016 , ... Robots will storm the Prudential Center in Boston, MA ... event, which is held on the United Nations International Day of Persons with Disabilities, ... the workplace. Suitable Technologies is partnering with NTI to showcase how technology can help ...
(Date:11/30/2016)... , ... November 30, 2016 , ... ... moving magnet Voice Coil Actuator with a flexure design that ensures high alignment ... with cost-effective pricing and is ideally suited where extreme precision is required, such ...
(Date:11/30/2016)... Biotest Pharmaceuticals Corporation (BPC), a leading manufacturer ... addition of its newest plasma collection center located at ... The 15,200 square foot state-of-the-art facility officially opened its ... the total number of BPC,s plasma collection centers to ... Chief Executive Officer said "We are pleased to become ...
(Date:11/30/2016)... DIEGO and BEIJING , ... a leading commercial provider of genomic services and solutions ... announced today that it has completed a USD $75 ... Merchants Bank Co., Ltd.,s CMB International Capital Management ( ... Innovation Investment Management Co., Ltd. ("SDIC Innovation") and Shanghai ...
Breaking Biology Technology:
Cached News: