HOME >> BIOLOGY >> NEWS
Studies reveal methods viruses use to sidestep immune system

DALLAS Feb. 14, 2005 A series of studies by researchers at UT Southwestern Medical Center sheds light on the mechanisms used by viruses to thwart a host's immune defenses and may aid in the development of more effective drugs to fight hepatitis C and West Nile viruses, as well as the flu and the common cold.

In a study to appear in a March issue of the Journal of Virology and currently available online, UT Southwestern researchers describe how an essential gene, called RIG-I, turns on a cascade of host immune defenses when the hepatitis C virus (HCV) replicates in cultured human cells.

Those immune defenses should fight off the virus, but in a separate study, scheduled to appear online this week and in an upcoming issue of the Proceedings of the National Academy of Sciences, the researchers show how HCV sidesteps the immune response, allowing the virus to replicate unchecked.

Dr. Michael Gale, associate professor of microbiology at UT Southwestern and senior author of the two studies, said the tactics employed by HCV to infect a host are likely to be similar to those employed by other RNA viruses such as West Nile, influenza and the common cold.

"This work has broad implications that go beyond just the hepatitis C virus, and that's what we're most excited about," said Dr. Gale. "It's a battle between viruses and humans. Viruses have co-evolved with their hosts, so every time we have evolved a gene with a new function that allows us to fight off a virus, the virus adapts and comes up with a new function of its own to counteract our defenses."

Further defining how RNA viruses target and control host immune defenses will aid in drug development to combat disease, he said.

In the Virology paper, Dr. Gale and his research group found that a specific mutation in the gene RIG-I conferred permissiveness to HCV, allowing it to replicate "like gangbusters" in those cells with the mutation, Dr. Gale said. He and his group determined that
'"/>

Contact: Amanda Siegfried
amanda.siegfried@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
14-Feb-2005


Page: 1 2 3

Related biology news :

1. Studies to find better ways to preserve human eggs, ovarian tissue under way
2. Studies assess effectiveness of serotonin and nerve stimulants on irritable bowel syndromes
3. The Institute of Ecosystem Studies recognized by the Wildlife Society
4. The Institute of Ecosystem Studies to host an international conference on ecology and urban design
5. Hot flashes -- Studies explore the role of genes, obesity and alcohol
6. Studies force new view on biology of flavonoids
7. Studies of population genetics, evolution are an exercise in bad taste
8. Studies identify DNA regions linked to nicotine dependence
9. Studies at cancer conference show new therapies changing outlook for blood cancer patients
10. Studies find general mechanism of cellular aging
11. Institute of Ecosystem Studies director and scientist honored by the Botanical Society of America

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/22/2018)... ... , ... Women who undergo breast implant surgery naturally want ... them against uninsured expenses for unexpected complications. Women can now elect low-cost, extensive ... for greater peace of mind if an issue should arise, and the ...
(Date:9/15/2018)... , ... September 14, 2018 , ... The first ever ... of clearance of green, blue, and purple tattoo inks - often the colors most ... Medicine (LSM), the official journal of the American Society for Laser Medicine and Surgery, ...
(Date:9/12/2018)... ... September 10, 2018 , ... IONpathTM, a venture-backed commercial-stage ... Multiplexed Ion Beam Imaging (MIBITM) technology was accepted by the journal Cell and ... shared during a webinar presented by Dr. Mike Angelo on October 2nd, 2018. ...
Breaking Biology News(10 mins):
(Date:9/12/2018)... Calif. and VIENNA, Austria (PRWEB) , ... September 10, 2018 , ... ... leading supplier of Semantic Graph Database technology, AllegroGraph , for Knowledge Graphs, and ... leading provider of Semantic AI solutions, today announced a partnership to develop the ...
(Date:9/7/2018)... (PRWEB) , ... September 05, 2018 , ... Now available ... Systems will be held on Sept. 19, 2018. With a panel of industry leaders ... this exciting event will reveal industry insights from experts in the field. Register ...
(Date:9/7/2018)... (PRWEB) , ... September 06, 2018 , ... Akadeum Life ... has spent his career as an executive and leader of numerous biotech companies. ... cell therapy and biologics company acquired by Thompson Street Capital in St. Louis, MO. ...
(Date:8/29/2018)... ... August 28, 2018 , ... ... announced today the successful completion of a $5.5 million funding round managed by ... Investment Fund, Commenda Capital, and Ellipsis Ventures. , “Our investment in Nanovis is ...
Breaking Biology Technology:
Cached News: